﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Travers, J
   Romero-Ortuno, R
   She, EN
   Cooney, MT
AF Travers, John
   Romero-Ortuno, Roman
   She, Eidin Ni
   Cooney, Marie-Therese
TI Involving older people in co-designing an intervention to reverse
   frailty and build resilience
SO FAMILY PRACTICE
LA English
DT Article
DE Frailty; older people; PPI; primary-care; public and patient
   involvement; resilience
ID PUBLIC INVOLVEMENT; COMMUNITY; FITNESS; PATIENT
AB Background: An essential consideration in health research is to conduct research with members of the public rather than for them. Public and patient involvement (PPI) of older people in research can improve enrolment, relevance and impact. However, few studies with PPI in frailty research have been identified. PPI has fallen during the Covid-19 pandemic.
   Objective: We aimed to involve older people in co-designing a randomised control trial (RCT) intervention to reverse frailty and build resilience. We also wished to encourage wider use of PPI with older people by outlining our approach.
   Methods: Involvement of older people was undertaken in three stages. Eighteen over 65-year-olds helped co-design an exercise intervention in two group discussions using the Socratic education method. Ninety-four contributed intervention feedback in one-on-one telephone interviews over nine months. Ten contributors helped optimise the intervention in three online workshops. Multidisciplinary team input and systematic review supported co-design.
   Results: Eleven home-based resistance exercises were co-designed by group discussion contributors (mean age 75, 61% female). Frailty intervention format, gender balance and GP follow-up were shaped in telephone interviews (mean age 77, 63% female). Dietary guidance and patient communication were co-designed in workshops (mean age 71, 60% females). Technology proved no barrier to PPI. The co-designed frailty intervention is being evaluated in a definitive RCT.
   Conclusions: We enabled meaningful the involvement of 112 older people in the co-design of an intervention to reverse frailty and build resilience in diverse ways. Inclusive involvement can be achieved during a pandemic. Feedback enhanced intervention feasibility for real-world primary-care.
   Lay Summary
   Our research paper describes how we involved 112 older adults in the co-design of an intervention aiming to reverse frailty and build resilience. Involving participants in research can improve its feasibility and impact. However, there have been few studies involving older people in frailty research and involvement has fallen further during the Covid-19 pandemic. Involvement of older people was undertaken in three stages. Eighteen over 65-year-olds helped co-design an exercise intervention in two group discussions. Ninety-four older adults contributed intervention feedback in one-on-one telephone interviews over nine months. Ten contributors helped optimise the intervention in three online workshops. The co-designed intervention involved resistance exercises and dietary guidance and will be tested in a full randomised control trial. We enabled the meaningful involvement of 112 older people in our research in diverse ways. Inclusive involvement can be achieved during a pandemic.
C1 [Travers, John; Cooney, Marie-Therese] Univ Coll Dublin, Sch Med, Dublin, Ireland.
   [Travers, John] Trinity Coll Dublin, HSE Specialist Training Programme Gen Practice, Dublin, Ireland.
   [Romero-Ortuno, Roman] Trinity Coll Dublin, Global Brain Hlth Inst, Dublin, Ireland.
   [Romero-Ortuno, Roman] St James Hosp, Mercers Inst Successful Aging, Dublin, Ireland.
   [She, Eidin Ni] Univ New South Wales, Fac Med & Hlth, Sch Populat Hlth, Sydney, NSW, Australia.
   [Cooney, Marie-Therese] St Vincents Univ Hosp, Dept Geriatr Med, Dublin, Ireland.
RP Travers, J (通讯作者)，Univ Coll Dublin, Sch Med, Dublin, Ireland.
EM john.travers.1@ucdconnect.ie
OI Romero-Ortuno, Roman/0000-0002-3882-7447; Ni She,
   Eidin/0000-0002-1036-6044; Travers, John/0000-0001-5778-9629
CR Angevaare MJ, 2020, FRONT MED-LAUSANNE, V7, DOI 10.3389/fmed.2020.00365
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NR 36
TC 0
Z9 0
U1 2
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0263-2136
EI 1460-2229
J9 FAM PRACT
JI Fam. Pr.
PD FEB
PY 2022
VL 39
IS 1
BP 200
EP 206
DI 10.1093/fampra/cmab084
PG 7
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 2A7FC
UT WOS:000809662300028
PM 34268566
OA Green Published, hybrid
DA 2022-07-18
ER

PT J
AU Spiller, TR
   Mean, M
   Ernst, J
   Sazpinar, O
   Gehrke, S
   Paolercio, F
   Petry, H
   Pfaltz, MC
   Morina, N
   Aebischer, O
   Gachoud, D
   von Kanel, R
   Weilenmann, S
AF Spiller, Tobias R.
   Mean, Marie
   Ernst, Jutta
   Sazpinar, Onur
   Gehrke, Samuel
   Paolercio, Francesca
   Petry, Heidi
   Pfaltz, Monique C.
   Morina, Naser
   Aebischer, Oriane
   Gachoud, David
   von Kaenel, Roland
   Weilenmann, Sonja
TI Development of health care workers' mental health during the SARS-CoV-2
   pandemic in Switzerland: two cross-sectional studies
SO PSYCHOLOGICAL MEDICINE
LA English
DT Letter
DE COVID-19; health care workers; mental health; pandemic; SARS-CoV-2;
   Switzerland
ID GENERALIZED ANXIETY DISORDER; DEPRESSION; QUALITY; IMPACT
AB Background Virus outbreaks such as the current SARS-CoV-2 pandemic are challenging for health care workers (HCWs), affecting their workload and their mental health. Since both, workload and HCW's well-being are related to the quality of care, continuous monitoring of working hours and indicators of mental health in HCWs is of relevance during the current pandemic. The existing investigations, however, have been limited to a single study period. We examined changes in working hours and mental health in Swiss HCWs at the height of the pandemic (T1) and again after its flattening (T2).
   Methods We conducted two cross-sectional online studies among Swiss HCWs assessing working hours, depression, anxiety, and burnout. From each study, 812 demographics-matched participants were included into the analysis. Working hours and mental health were compared between the two samples.
   Results Compared to prior to the pandemic, the share of participants working less hours was the same in both samples, whereas the share of those working more hours was lower in the T2 sample. The level of depression did not differ between the samples. In the T2 sample, participants reported more anxiety, however, this difference was below the minimal clinically important difference. Levels of burnout were slightly higher in the T2 sample.
   Conclusions Two weeks after the health care system started to transition back to normal operations, HCWs' working hours still differed from their regular hours in non-pandemic times. Overall anxiety and depression among HCWs did not change substantially over the course of the current SARS-CoV-2 pandemic.
C1 [Spiller, Tobias R.; Pfaltz, Monique C.; Morina, Naser; von Kaenel, Roland] Univ Zurich, Dept Med, Zurich, Switzerland.
   [Spiller, Tobias R.; Gehrke, Samuel; Pfaltz, Monique C.; Morina, Naser; von Kaenel, Roland; Weilenmann, Sonja] Univ Zurich, Zurich, Switzerland.
   [Spiller, Tobias R.; Gehrke, Samuel; Pfaltz, Monique C.; Morina, Naser; von Kaenel, Roland; Weilenmann, Sonja] Univ Hosp Zurich, Dept Consultat Liaison Psychiat & Psychosomat Med, Zurich, Switzerland.
   [Mean, Marie; Gachoud, David] Lausanne Univ Hosp, Dept Internal Med, Lausanne, Switzerland.
   [Ernst, Jutta; Petry, Heidi] Univ Hosp Zurich, Ctr Clin Nursing Sci, Zurich, Switzerland.
   [Sazpinar, Onur] Spital Zollikerberg, Dept Internal Med, Zollikon, Switzerland.
   [Paolercio, Francesca] Univ Zurich, Dept Psychol, Zurich, Switzerland.
   [Aebischer, Oriane; Gachoud, David] Univ Lausanne, Fac Biol & Med, Sch Med, Educ Unit, Lausanne, Switzerland.
RP Spiller, TR (通讯作者)，Univ Zurich, Dept Med, Zurich, Switzerland.; Spiller, TR (通讯作者)，Univ Zurich, Zurich, Switzerland.; Spiller, TR (通讯作者)，Univ Hosp Zurich, Dept Consultat Liaison Psychiat & Psychosomat Med, Zurich, Switzerland.
EM tobias.r.spiller@gmail.com
RI Gachoud, David/AAS-8255-2021; Morina, Naser/AAC-7377-2020; Spiller,
   Tobias Raphael/J-2566-2019
OI Gachoud, David/0000-0001-9843-8761; Morina, Naser/0000-0002-6470-4408;
   Spiller, Tobias Raphael/0000-0002-0107-0743; Pfaltz,
   Monique/0000-0002-4030-4514; Weilenmann, Sonja/0000-0002-6910-521X;
   Ernst, Jutta/0000-0001-7619-8314; Petry, Heidi/0000-0001-5220-4273;
   Aebischer, Oriane/0000-0003-3193-7093
FU Forschungskredit of the University of Zurich [FK-19-048]
FX Tobias R. Spiller was supported by a Forschungskredit of the University
   of Zurich, grant no. FK-19-048.
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NR 17
TC 11
Z9 11
U1 0
U2 1
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD MAY
PY 2022
VL 52
IS 7
BP 1395
EP 1398
AR PII S0033291720003128
DI 10.1017/S0033291720003128
PG 4
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 1S1TA
UT WOS:000803839800021
PM 32787976
OA Green Published, hybrid
DA 2022-07-18
ER

PT J
AU Dillon, MR
   Bolyen, E
   Adamov, A
   Belk, A
   Borsom, E
   Burcham, Z
   Debelius, JW
   Deel, H
   Emmons, A
   Estaki, M
   Herman, C
   Keefe, CR
   Morton, JT
   Oliveira, RRM
   Sanchez, A
   Simard, A
   Vazquez-Baeza, Y
   Ziemski, M
   Miwa, HE
   Kerere, TA
   Coote, C
   Bonneau, R
   Knight, R
   Oliveira, G
   Gopalasingam, P
   Kaehler, BD
   Cope, EK
   Metcalf, JL
   Robeson, MS
   Bokulich, NA
   Caporaso, JG
AF Dillon, Matthew R.
   Bolyen, Evan
   Adamov, Anja
   Belk, Aeriel
   Borsom, Emily
   Burcham, Zachary
   Debelius, Justine W.
   Deel, Heather
   Emmons, Alex
   Estaki, Mehrbod
   Herman, Chloe
   Keefe, Christopher R.
   Morton, Jamie T.
   Oliveira, Renato R. M.
   Sanchez, Andrew
   Simard, Anthony
   Vazquez-Baeza, Yoshiki
   Ziemski, Michal
   Miwa, Hazuki E.
   Kerere, Terry A.
   Coote, Carline
   Bonneau, Richard
   Knight, Rob
   Oliveira, Guilherme
   Gopalasingam, Piraveen
   Kaehler, Benjamin D.
   Cope, Emily K.
   Metcalf, Jessica L.
   Robeson, Michael S., II
   Bokulich, Nicholas A.
   Caporaso, J. Gregory
TI Experiences and lessons learned from two virtual, hands-on microbiome
   bioinformatics workshops
SO PLOS COMPUTATIONAL BIOLOGY
LA English
DT Article
AB In October of 2020, in response to the Coronavirus Disease 2019 (COVID-19) pandemic, our team hosted our first fully online workshop teaching the QIIME 2 microbiome bioinformatics platform. We had 75 enrolled participants who joined from at least 25 different countries on 6 continents, and we had 22 instructors on 4 continents. In the 5-day workshop, participants worked hands-on with a cloud-based shared compute cluster that we deployed for this course. The event was well received, and participants provided feedback and suggestions in a postworkshop questionnaire. In January of 2021, we followed this workshop with a second fully online workshop, incorporating lessons from the first. Here, we present details on the technology and protocols that we used to run these workshops, focusing on the first workshop and then introducing changes made for the second workshop. We discuss what worked well, what didn't work well, and what we plan to do differently in future workshops.
C1 [Dillon, Matthew R.; Bolyen, Evan; Borsom, Emily; Herman, Chloe; Keefe, Christopher R.; Sanchez, Andrew; Simard, Anthony; Cope, Emily K.; Caporaso, J. Gregory] No Arizona Univ, Pathogen & Microbiome Inst, Ctr Appl Microbiome Sci, Flagstaff, AZ 86011 USA.
   [Adamov, Anja; Ziemski, Michal; Bokulich, Nicholas A.] Swiss Fed Inst Technol, Inst Food Nutr & Hlth, Lab Food Syst Biotechnol, Zurich, Switzerland.
   [Adamov, Anja; Belk, Aeriel; Burcham, Zachary; Deel, Heather; Emmons, Alex; Metcalf, Jessica L.] Colorado State Univ, Cell & Mol Biol Special Acad Unit, Dept Anim Sci, Ft Collins, CO 80523 USA.
   [Debelius, Justine W.] Karolinska Inst, Ctr Translat Microbiome Res, Dept Microbiol Tumor & Canc Biol, Stockholm, Sweden.
   [Estaki, Mehrbod; Knight, Rob] Univ Calif San Diego, Dept Pediat, San Diego, CA 92103 USA.
   [Morton, Jamie T.; Bonneau, Richard] Flatiron Inst Simons Fdn, Ctr Computat Biol, New York, NY USA.
   [Oliveira, Renato R. M.; Oliveira, Guilherme] Inst Tecnol Vale, Environm Genom, Belem, Para, Brazil.
   [Vazquez-Baeza, Yoshiki; Knight, Rob] Univ Calif San Diego, Jacobs Sch Engn, Ctr Microbiome Innovat, San Diego, CA 92103 USA.
   [Miwa, Hazuki E.; Kerere, Terry A.; Coote, Carline] NIH, Fdn Adv Educ Sci, Acad Programs, Bldg 10, Bethesda, MD 20892 USA.
   [Gopalasingam, Piraveen] European Bioinformat Inst EMBL EBI, European Mol Biol Lab, Hinxton, Cambs, England.
   [Kaehler, Benjamin D.] Univ New South Wales, Sch Sci, Canberra, ACT, Australia.
   [Robeson, Michael S., II] Univ Arkansas Med Sci, Coll Med, Dept Biomed Informat, Little Rock, AR 72205 USA.
RP Caporaso, JG (通讯作者)，No Arizona Univ, Pathogen & Microbiome Inst, Ctr Appl Microbiome Sci, Flagstaff, AZ 86011 USA.
EM greg.caporaso@nau.edu
RI Robeson, Michael Scott/J-5211-2019; Debelius, Justine/ABE-7272-2021;
   Bonneau, Richard/ABD-6737-2021; Meador, Andrew Sanchez/AAD-8223-2019
OI Robeson, Michael Scott/0000-0001-7119-6301; Meador, Andrew
   Sanchez/0000-0003-4238-8587; Burcham, Zachary/0000-0003-1600-9643;
   Gopalasingam, Piraveen/0000-0001-5709-3373; Adamov,
   Anja/0000-0002-7506-1583; Keefe, Christopher/0000-0002-4289-0991;
   Knight, Rob/0000-0002-0975-9019; Dillon, Matthew/0000-0002-7713-1952;
   Deel, Heather/0000-0002-9429-9052; Emmons,
   Alexandra/0000-0002-5637-105X; Borsom, Emily/0000-0001-6379-2517;
   Estaki, Mehrbod/0000-0003-4556-8444; Debelius,
   Justine/0000-0002-8605-3546
FU Chan-Zuckerberg Initiative Essential Open Source Software award
   [2019207342]; NIH National Cancer Institute Informatics Technology for
   Cancer Research Award [1U24CA248454-01]; NIH National Cancer Institute
   awards under the Partnership for Native American Cancer Prevention
   [U54CA143925]; Alfred P Sloan Foundation
FX Funding for these events was provided in part by Chan-Zuckerberg
   Initiative Essential Open Source Software award 2019207342 to JGC; NIH
   National Cancer Institute Informatics Technology for Cancer Research
   Award 1U24CA248454-01 to JGC and RK; NIH National Cancer Institute
   awards under the Partnership for Native American Cancer Prevention
   U54CA143925 to JGC; a grant from the Alfred P Sloan Foundation to JGC
   (https://sloan.org/grant-detail/9231); and by workshop fees paid by
   participants. The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript.
CR Achakulvisut T, 2020, ELIFE, V9, DOI 10.7554/eLife.57892
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   Sarabipour S, 2020, ELIFE, V9, DOI 10.7554/eLife.62668
NR 8
TC 0
Z9 0
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-734X
EI 1553-7358
J9 PLOS COMPUT BIOL
JI PLoS Comput. Biol.
PD JUN
PY 2021
VL 17
IS 6
AR e1009056
DI 10.1371/journal.pcbi.1009056
PG 18
WC Biochemical Research Methods; Mathematical & Computational Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Mathematical & Computational Biology
GA TF3LJ
UT WOS:000670616600002
PM 34166363
OA gold, Green Published
DA 2022-07-18
ER

PT J
AU Marendic, M
   Bokan, I
   Buljan, I
   Dominikovic, P
   Suton, R
   Kolcic, I
AF Marendic, Mario
   Bokan, Ivana
   Buljan, Ivan
   Dominikovic, Paula
   Suton, Ruzica
   Kolcic, Ivana
TI Adherence to epidemiological measures and related knowledge and
   attitudes during the coronavirus disease 2019 epidemic in Croatia: a
   cross-sectional study
SO CROATIAN MEDICAL JOURNAL
LA English
DT Article
ID COVID-19
AB Aim To assess the use of personal protective equipment (PPE) and related knowledge and attitudes during the coronavirus disease 2019 epidemic in Croatia.
   Methods The online survey, conducted on social media in May 2020, yielded 1393 responses across the country (66% from the Adriatic area). The questionnaire consisted of socio-demographic questions and questions on the knowledge, attitudes, and behaviors related to PPE use. The chi(2) test, t test, and multivariate logistic regression were used in data analysis.
   Results As many as 84.0% of participants reported the compliance with social distancing measures, while 52.8% reported using PPE (mask and/or gloves) when shopping or visiting friends and family. Participants demonstrated good knowledge (mean of 10.4 [95% CI 10.3-10.4] correct answers out of 13 questions) and neutral to moderately positive attitude about PPE use (mean of 36.6 [36.1-37.1] out of 50 points). Participants with higher education, women, and health care workers had a greater probability for having a high knowledge score. Women, older individuals, public transport users, people with more positive PPE use attitude, and those who complied with social distancing had a higher probability of PPE use, while health care workers and highly educated participants had a reduced probability of PPE use in public.
   Conclusions Croatians had good knowledge and neutral to moderately positive attitudes about PPE use. Nevertheless, health authorities need to promote positive attitudes about PPE use in order to retain trust and compliance with epidemiological measures.
C1 [Marendic, Mario] Univ Split, Univ Dept Hlth Studies, Dept Nursing, Split, Croatia.
   [Bokan, Ivana] Hlth Sch Split, Dept Nursing, Split, Croatia.
   [Buljan, Ivan] Univ Split, Dept Res Biomed & Hlth, Sch Med, Split, Croatia.
   [Dominikovic, Paula] Univ Split, Univ Dept Hlth Studies, Rudera Boskovica 35, Split 21000, Croatia.
   [Suton, Ruzica] Univ Hosp Ctr Split, Univ Dept Hlth Studies, Dept Neurol, Split, Croatia.
   [Kolcic, Ivana] Univ Split, Dept Publ Hlth, Sch Med, Split, Croatia.
RP Marendic, M (通讯作者)，Univ Split, Univ Dept Hlth Studies, Rudera Boskovica 35, Split 21000, Croatia.
EM mario.marendic@ozs.unist.hr
RI Buljan, Ivan/B-4671-2019; Marendić, Mario/AAA-2867-2021; Marendić,
   Mario/X-5987-2019; Kolcic, Ivana/E-2713-2017
OI Buljan, Ivan/0000-0002-8719-7277; Marendić, Mario/0000-0002-2968-1175;
   Marendić, Mario/0000-0002-2968-1175; Bokan, Ivana/0000-0002-3585-8432;
   Kolcic, Ivana/0000-0001-7918-6052
CR Abdelhafiz AS, 2020, J COMMUN HEALTH, V45, P881, DOI 10.1007/s10900-020-00827-7
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   Bekele F, 2020, SAGE OPEN MED, V8, DOI 10.1177/2050312120970721
   Blavatnik School of Government UoO, 2020, REL NUMB COVID 19 CA
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   Civil Protection Directorate (CPD), 2020, DEC CIV PROT DIR REP
   Civil Protection Directorate (CPD), 2020, NEW REC INSTR CROAT
   Civil Protection Directorate (CPD), 2020, MEAS LAUNCH EC OTH A
   Croatian Institute of Public Health, 2020, COVID 19 STAT 1 CAS
   Croatian Institute of Public Health (CIPH), 2020, RAT US PERS PROT EQ
   Croatian Institute of Public Health (CIPH), 2020, ADD MEAS PREV ENTR S
   Croatian institute of Public Health (CIPH), 2020, INSTR OBL WEAR FAC M
   Croatian Institute of Public Health (CIPH), 2020, REC WORK ACT PASS TR
   Croatian Institute of Public Health (CIPH), 2020, REC US FAC MASKS MED
   Croatian Institute of Public Health (CIPH), 2020, REC PREV INF STOR WI
   Dogas Z, 2020, CROAT MED J, V61, P309, DOI 10.3325/cmj.2020.61.309
   Hamza MS, 2021, J COMMUN HEALTH, V46, P139, DOI 10.1007/s10900-020-00859-z
   Huynh G, 2020, J TROPICAL MED, V13, P260, DOI DOI 10.4103/1995-7645.280396
   OECD (Organization for Economic Co-operation and Development), 2020, WORLD EC TIGHTR
   Parikh PA, 2020, CUREUS, V12, DOI 10.7759/cureus.8144
   Salman M, 2020, DRUGS THER PERSPECT, V36, P319, DOI 10.1007/s40267-020-00737-7
   Skoric L, 2020, CROAT MED J, V61, P79, DOI 10.3325/cmj.2020.61.79
   Van Dyke ME, 2020, MMWR-MORBID MORTAL W, V69, P1777, DOI 10.15585/mmwr.mm6947e2
   Wahed WYA, 2020, J COMMUNITY HLTH, P1, DOI DOI 10.1007/S10900-019-00710-0
   WHO, 2020, PROT YOURS OTH SPREA
   World Health Organization, 2020, QUEST ANSW COR COVID
   World Health Organization, 2020, 38 WHO
   World Health Organization, 2020, CORONAVIRUS DIS COVI
   World Health Organization, 2020, ADVICE USE MASKS CON
   World Health Organization, 2020, PNEUM UNKN CAUS CHIN
   World Health Organization (WHO), 2020, CORR ADV US MASKS CO
   Yue S, 2020, J COMMUNITY HLTH, P1
   Zhong BL, 2020, INT J BIOL SCI, V16, P1745, DOI 10.7150/ijbs.45221
NR 35
TC 4
Z9 4
U1 2
U2 3
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-9504
EI 1332-8166
J9 CROAT MED J
JI Croat. Med. J.
PD DEC
PY 2020
VL 61
IS 6
BP 508
EP 517
DI 10.3325/cmj.2020.61.508
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QT3KB
UT WOS:000626487700006
PM 33410297
OA gold, Green Published
DA 2022-07-18
ER

PT J
AU Hanson, N
   Diaz, G
   Romero, J
   Steen, S
AF Hanson, Nicole
   Diaz, Graal
   Romero, Javier
   Steen, Shawn
TI Can Customized YouTube Videos Improve ABSITE Performance?
SO AMERICAN SURGEON
LA English
DT Article; Early Access
DE ABSITE; youtube
AB Introduction The COVID-19 pandemic decreased in-person didactic sessions in our general surgery residency. We piloted a program to develop online tutorials posted to a YouTube channel designed to prepare our residents for the ABSITE examination. Methods Study participants were General Surgery residents in our five-year ACGME accredited general surgery residency program who took the ABSITE in-service exam between 2019 and 2021. We compared raw scores and overall programmatic percentile scores for three academic years (2018-2019, 2019-2020, and 2020-2021). Results From academic year 2018-2019 to 2019-2020, before introducing the YouTube teaching platform, average raw scores and percentile scores among our general surgery residents remained unchanged (raw scores 64 - 65% (p = ns), percentile scores 39 to 37% (p = ns)). However, raw ABSITE scores increased significantly after introducing the YouTube teaching platform. A one-way ANOVA showed a statistically significant difference in raw ABSITE scores for AY 2020-2021 compared to the two prior years (F(2, 30) = [1.193], P < 0.01). Mean percentile ranking scores (program-wide) increased 15% from AY 2018-2019 to AY 2020-2021 (Figure1). Conclusion Teaching via an online platform such as YouTube allows residents to review material at their own pace and schedule. It is other our hypothesis is that the online YouTube material presented in the Ventura Surgery School channel contributed, in part, to this relative improvement compared to resident peers in other institutions. Teaching via an online platform could be a valuable tool to educate surgical learners in our ever-changing teaching environment.
C1 [Hanson, Nicole; Diaz, Graal; Romero, Javier; Steen, Shawn] Community Mem Hlth Syst, Ventura, CA 93003 USA.
RP Hanson, N (通讯作者)，Community Mem Hlth Syst, Dept Grad Med Educ, Gen Surg, 147 N Brent St, Ventura, CA 93003 USA.
EM nhanson@cmhshealth.org
CR [Anonymous], SKETCHYMEDICAL
   Coe TM, 2020, ANN SURG, V272, pE139, DOI 10.1097/SLA.0000000000003993
   Dedeilia A, 2020, IN VIVO, V34, P1603, DOI 10.21873/invivo.11950
   Ehrlich H, 2020, WORLD J SURG, V44, P2053, DOI 10.1007/s00268-020-05574-3
   Gladwin M., 2014, CLIN MICROBIOLOGY MA
   Vasavda C, 2021, MED SCI EDUC, V31, P231, DOI 10.1007/s40670-020-01127-4
   White EM, 2021, J SURG EDUC, V78, P412, DOI 10.1016/j.jsurg.2020.07.036
   Wise CE, 2021, J SURG RES, V264, P534, DOI 10.1016/j.jss.2021.01.017
   Wlodarczyk JR, 2021, AM J SURG, V221, P962, DOI 10.1016/j.amjsurg.2020.08.045
NR 9
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
AR 00031348221109492
DI 10.1177/00031348221109492
EA JUN 2022
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 2I5RK
UT WOS:000815034900001
PM 35731197
DA 2022-07-18
ER

PT J
AU Ammann, P
   Ulyte, A
   Haile, SR
   Puhan, MA
   Kriemler, S
   Radtke, T
AF Ammann, Priska
   Ulyte, Agne
   Haile, Sarah R.
   Puhan, Milo A.
   Kriemler, Susi
   Radtke, Thomas
TI Perceptions towards mask use in school children during the SARS-CoV-2
   pandemic: descriptive results from the longitudinal Ciao Corona cohort
   study
SO SWISS MEDICAL WEEKLY
LA English
DT Article
ID COVID-19
AB BACKGROUND: Mask wearing contributes to the reduction of transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In Switzerland, compulsory use of masks was introduced in indoor public spaces and later in schools. This study explored perceptions of the usefulness of masks in school and public in a cohort of children and adolescents in the canton of Zurich, Switzerland, in January to May 2021.
   METHODS: School children aged 10 to 17 years enrolled in Ciao Corona, a prospective school-based cohort study, responded to nested online surveys between 12 January and 24 March 2021 (Q1) and 10 March and 16 May 2021 (Q2). Secondary school children were surveyed at Q1 and Q2, and primary school children at Q2 only. Surveys for parents and their children included questions on the children's perception of the usefulness of masks and mask wearing behaviour by applying a non-validated questionnaire. Associations between perceived usefulness of masks and child's school level and gender, and parents' educational attainment were analysed with Pearson's and McNemar's chi-square tests. Free-text comments provided by children were classified into categories of expressed attitude towards mask wearing.
   RESULTS: A total of 595 (54% girls) and 1118 (52% girls) school children with predominantly Swiss nationality and a high socioeconomic status responded to online questionnaires at Q1 and Q2, respectively. More than half of the school children perceived masks to be useful at school (Q1: 60% and Q2: 57%) and in public (Q1: 69% and Q2 :60%). Girls perceived masks as useful more often than boys (at Q2 at school: 61% versus 53%, in public: 64% versus 57%), and children of parents with high educational attainment more often than those of parents with lower educational attainment (at Q2 at school: 61% versus 49%, in public: 63% versus 54%). At Q1 and Q2 each, about 20% of children provided individual statements about masks, of which 36% at Q1 and 16% at Q2 reported side effects and discomfort such as skin irritations, headache or difficulties breathing during physical education.
   CONCLUSIONS: Approximately 60% of school children perceived masks at school and in public places as useful. A small but non-negligible proportion of children reported discomfort and side effects that should be considered to ensure high adherence to mask wearing among school children. A validation of the questionnaire is needed.
C1 [Ammann, Priska; Ulyte, Agne; Haile, Sarah R.; Puhan, Milo A.; Kriemler, Susi; Radtke, Thomas] Univ Zurich, Dept Epidemiol, EBPI, Zurich, Switzerland.
RP Radtke, T (通讯作者)，Univ Zurich, EBPI, CH-8001 Zurich, Switzerland.
EM thomas.radtke@uzh.ch
FU SSPH+; Swiss Federal Office of Public Health; Cantons of Switzerland;
   University of Zurich Foundation
FX This study is part of Corona Immunitas research network, coordinated by
   the Swiss School of Public Health (SSPH+), and funded by fundraising of
   SSPH+ that includes funds of the Swiss Federal Office of Public Health
   and private funders (ethical guidelines for funding stated by SSPH+ will
   be respected), by funds of some Cantons of Switzerland and by
   institutional funds of the Universities. Additional funding, specific to
   this study is available from the University of Zurich Foundation. The
   funder/sponsor did not have any role in the design and conduct of the
   study; collection, management, analysis, and interpretation of the data;
   preparation, review, or approval of the manuscript; and decision to
   submit the manuscript for publication.
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   UNICEF, COVID 19 SCH CLOS ON
   Viner RM, 2020, LANCET CHILD ADOLESC, V4, P397, DOI 10.1016/S2352-4642(20)30095-X
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   West EA, 2020, INT J PUBLIC HEALTH, V65, P1529, DOI 10.1007/s00038-020-01494-0
   Wilson RF, 2020, MMWR-MORBID MORTAL W, V69, P1497, DOI 10.15585/mmwr.mm6941e2
   World Health Organization (WHO) and United Nations Children's Fund, ADV US MASKS CHILDR
   Zhang B, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18199988
   Zimmerman KO, 2021, PEDIATRICS, V147, DOI 10.1542/peds.2020-048090
NR 46
TC 0
Z9 0
U1 2
U2 2
PU E M H SWISS MEDICAL PUBLISHERS LTD
PI MUTTENZ
PA FARNSBURGERSTR 8, CH-4132 MUTTENZ, SWITZERLAND
SN 1424-7860
EI 1424-3997
J9 SWISS MED WKLY
JI Swiss Med. Wkly.
PD APR 20
PY 2022
VL 152
AR w30165
DI 10.4414/SMW.2022.w30165
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 0U6OE
UT WOS:000787768100001
PM 35748765
OA gold
DA 2022-07-18
ER

PT J
AU Sen, V
   Eren, H
   Kazaz, IO
   Goger, YE
   Izol, V
   Tarhan, H
   Argun, B
   Akbal, C
   Mungan, A
   Esen, AA
AF Sen, Volkan
   Eren, Huseyin
   Kazaz, Ilke Onur
   Goger, Yunus Emre
   Izol, Volkan
   Tarhan, Huseyin
   Argun, Burak
   Akbal, Cem
   Mungan, Aydin
   Esen, Ahmet Adil
TI Easily accessible, up-to-date and standardised training model in
   Urology: E-Learning Residency training programme (ERTP)
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Article
AB Objectives There is no standardised and up-to-date education model for urology residents in our country. We aimed to describe our National E-learning education model for urology residents. Methodology The ERTP working group; consisting of urologists was established by the Society of Urological Surgery to create E-learning model and curriculum in April 2018. Learning objectives were set up in order to determine and standardise the contents of the presentations. In accordance with the Bloom Taxonomy, 834 learning objectives were created for a total of 90 lectures (18 lectures for each PGY year). Totally 90 videos were shot by specialised instructors and webcasts were prepared. Webcasts were posted at uropedia.com.tr, which is the web library of the Society of Urological Surgery. The satisfaction of residents and instructors was evaluated with feedbacks. An assessment of knowledge was measured with the multiple-choice exam. Results A total of 43 centres and 250 urology residents were included in ERTP during the academic year 2018/2019. There were 93/55/43/34/25 urology residents at 1st/2nd/3rd/4th and 5th year of residency, respectively. Majority of the residents (99.1%) completed the ERTP. The overall satisfaction rate of residents and instructors were 4.29 and 4.67 (min: 1 so bad, max: 5 so good). An assessment exam was performed to urology residents at the end of the ERTP and the mean score was calculated as 57.99 points (min: 20, max: 82). Conclusion As a result of the COVID-19 pandemic, most of the educational programmes had to move online platforms. We used this reliable and easily accessible e-learning platform for the standardisation of training in urology on national basis. We aim to share this model with international residency training programmes.
C1 [Sen, Volkan] Manisa State Hosp, Dept Urol, Manisa, Turkey.
   [Eren, Huseyin] Recep Tayyip Erdogan Univ, Dept Urol, Fac Med, Rize, Turkey.
   [Kazaz, Ilke Onur] Karadeniz Tech Univ, Dept Urol, Fac Med, Trabzon, Turkey.
   [Goger, Yunus Emre] Necmettin Erbakan Univ, Meram Fac Med, Dept Urol, Konya, Turkey.
   [Izol, Volkan] Cukurova Univ, Dept Urol, Fac Med, Adana, Turkey.
   [Tarhan, Huseyin] Mugla Sitki Kocman Univ, Dept Urol, Fac Med, Mugla, Turkey.
   [Argun, Burak; Akbal, Cem] Acibadem Mehmet Ali Aydinlar Univ, Dept Urol, Fac Med, Istanbul, Turkey.
   [Mungan, Aydin] Bulent Ecevit Univ, Dept Urol, Fac Med, Zonguldak, Turkey.
   [Esen, Ahmet Adil] Dokuz Eylul Univ, Dept Urol, Fac Med, Izmir, Turkey.
RP Sen, V (通讯作者)，Manisa State Hosp, Dept Urol, Manisa, Turkey.
EM sen_volkan@yahoo.com
RI Sen, Volkan/AAA-1576-2020; Esen, Ahmet/ABH-4489-2020; Kazaz,
   İlke/AAL-5987-2021
OI Sen, Volkan/0000-0003-2832-0682; 
CR Back DA, 2019, ORTHOP TRAUMATOL-SUR, V105, P389, DOI 10.1016/j.otsr.2019.01.002
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NR 15
TC 4
Z9 4
U1 3
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-5031
EI 1742-1241
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD MAR
PY 2021
VL 75
IS 3
AR e13683
DI 10.1111/ijcp.13683
EA SEP 2020
PG 5
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA QO6WF
UT WOS:000566529900001
PM 32810325
DA 2022-07-18
ER

PT J
AU Kumar, S
   Bishnoi, A
   Vinay, K
AF Kumar, Sheetanshu
   Bishnoi, Anuradha
   Vinay, Keshavamurthy
TI Changing paradigms of dermatology practice in developing nations in the
   shadow ofCOVID-19: Lessons learnt from the pandemic
SO DERMATOLOGIC THERAPY
LA English
DT Article
DE Dermatology practice in shadow of COVID; Changing dermatology practice
   post COVID
AB At present, routine dermatology practices stay mostly disrupted worldwide owing to the ongoing COVID-19 pandemic. However, dermatology services need to be resumed in future and dermatologists especially in developing countries face a mammoth task of devising plans to tackle the upcoming surge of patients while still maintaining the precautions to avoid risk of infection to health care workers and our patients. Teledermatology practice is a viable alternative and there is need of starting functioning teledermatology centers at primary health care centers and training health care workers in telemedicine. Several steps like increasing the working hours of outpatient clinics, posting dermatologists and health staffs in shifts, encouraging online registration and payment, providing time slots to patients should be taken to prevent overcrowding at outpatient departments in hospitals of developing countries like India where the usual patient turnover during summers maybe around 600 to 800 per day. Once diagnosed by the dermatologist, a subsequent meticulous use of teledermatology can limit the number of follow-up visits. To avoid student gatherings, the undergraduate and postgraduate teaching schedule should be replaced by online or virtual teaching in form of webinars and video conferencing. Above all, intense upgradation of health care infrastructure, recruitment, training of new health care staffs on mass level and huge investment in health care sector is required in all the developing countries.
C1 [Kumar, Sheetanshu] All India Inst Med Sci, Dept Dermatol Venereol & Leprosy, Rishikesh, India.
   [Kumar, Sheetanshu; Bishnoi, Anuradha; Vinay, Keshavamurthy] Postgrad Inst Med Educ & Res, Dept Dermatol Venereol & Leprol, Chandigarh, India.
RP Vinay, K (通讯作者)，Postgrad Inst Med Educ & Res, Dept Dermatol Venereol & Leprol, Sect 12, Chandigarh 160012, India.
EM vinay.keshavmurthy@gmail.com
OI Vinay, Keshavamurthy/0000-0001-6323-4988; Kumar,
   Sheetanshu/0000-0002-6543-4649
CR Cavanagh G, 2020, J AM ACAD DERMATOL, V82, pE211, DOI 10.1016/j.jaad.2020.03.090
   Lee I, 2020, J AM ACAD DERMATOL, V82, P1213, DOI 10.1016/j.jaad.2020.03.052
   Mian A, 2020, BMC MED, V18, DOI 10.1186/s12916-020-01577-y
   Pulla P, 2020, BMJ-BRIT MED J, V368, DOI 10.1136/bmj.m1251
NR 4
TC 11
Z9 13
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1396-0296
EI 1529-8019
J9 DERMATOL THER
JI Dermatol. Ther.
PD JUL
PY 2020
VL 33
IS 4
AR e13472
DI 10.1111/dth.13472
EA MAY 2020
PG 3
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA NL4WM
UT WOS:000539383100001
PM 32347612
OA Green Published, Bronze
DA 2022-07-18
ER

PT J
AU Warschburger, P
   Petersen, AC
   von Rezori, RE
   Buchallik, F
   Baumeister, H
   Holl, RW
   Minden, K
   Muller-Stierlin, AS
   Reinauer, C
   Staab, D
AF Warschburger, Petra
   Petersen, Ann-Christin
   von Rezori, Roman E.
   Buchallik, Friederike
   Baumeister, Harald
   Holl, Reinhard W.
   Minden, Kirsten
   Mueller-Stierlin, Annabel S.
   Reinauer, Christina
   Staab, Doris
CA COACH Consortium
TI A prospective investigation of developmental trajectories of
   psychosocial adjustment in adolescents facing a chronic condition-study
   protocol of an observational, multi-center study
SO BMC PEDIATRICS
LA English
DT Article
DE Chronic conditions; Adolescents; Prospective; Quality of life;
   Resiliency; Coping; Protective factors; Type 1 diabetes; Juvenile
   idiopathic arthritis; Cystic fibrosis
ID GENERALIZED ANXIETY DISORDER; EMOTION REGULATION QUESTIONNAIRE;
   QUALITY-OF-LIFE; PEDIATRIC PHYSICAL DISORDERS; PSYCHOLOGICAL ADJUSTMENT;
   PSYCHOMETRIC EVALUATION; GERMAN VERSION; CHRONIC ILLNESS; SCREENER
   GAD-7; SELF-ESTEEM
AB Background: Relatively little is known about protective factors and the emergence and maintenance of positive outcomes in the field of adolescents with chronic conditions. Therefore, the primary aim of the study is to acquire a deeper understanding of the dynamic process of resilience factors, coping strategies and psychosocial adjustment of adolescents living with chronic conditions.
   Methods/design: We plan to consecutively recruit N = 450 adolescents (12-21 years) from three German patient registries for chronic conditions (type 1 diabetes, cystic fibrosis, or juvenile idiopathic arthritis). Based on screening for anxiety and depression, adolescents are assigned to two parallel groups - "inconspicuous" (PHQ-9 and GAD-7 < 7) vs. "conspicuous" (PHQ-9 or GAD-7 >= 7) - participating in a prospective online survey at baseline and 12-month follow-up. At two time points (T1, T2), we assess (1) intra- and interpersonal resiliency factors, (2) coping strategies, and (3) health-related quality of life, well-being, satisfaction with life, anxiety and depression. Using a cross-lagged panel design, we will examine the bidirectional longitudinal relations between resiliency factors and coping strategies, psychological adaptation, and psychosocial adjustment. To monitor Covid-19 pandemic effects, participants are also invited to take part in an intermediate online survey.
   Discussion: The study will provide a deeper understanding of adaptive, potentially modifiable processes and will therefore help to develop novel, tailored interventions supporting a positive adaptation in youths with a chronic condition. These strategies should not only support those at risk but also promote the maintenance of a successful adaptation.
C1 [Warschburger, Petra; Petersen, Ann-Christin; von Rezori, Roman E.; Buchallik, Friederike] Univ Potsdam, Dept Psychol Counseling Psychol, Karl Liebknecht Str 24-25, D-14476 Potsdam, Germany.
   [Baumeister, Harald] Ulm Univ, Fac Engn Comp Sci & Psychol, Inst Psychol & Educ, Dept Clin Psychol & Psychotherapy, Ulm, Germany.
   [Holl, Reinhard W.] Ulm Univ, ZIBMT, Inst Epidemiol & Med Biometry, Ulm, Germany.
   [Minden, Kirsten] Charite Univ Med Berlin, Berlin, Germany.
   [Minden, Kirsten] German Rheumatism Res Ctr, Berlin, Germany.
   [Mueller-Stierlin, Annabel S.] Ulm Univ, Dept Psychiat & Psychotherapy 2, BKH Gunzburg, Gunzburg, Germany.
   [Reinauer, Christina] Univ Hosp Dusseldorf, Dept Gen Pediat Neonatol & Pediat Cardiol, Dusseldorf, Germany.
   [Staab, Doris] Charite Univ Med Berlin, Dept Pediat Pulmonol Immunol & Intens Care Med, Berlin, Germany.
RP Warschburger, P (通讯作者)，Univ Potsdam, Dept Psychol Counseling Psychol, Karl Liebknecht Str 24-25, D-14476 Potsdam, Germany.
EM warschb@uni-potsdam.de
RI Mueller-Stierlin, Annabel Sandra/AAC-1241-2022
OI Mueller-Stierlin, Annabel Sandra/0000-0003-2812-5115; von Rezori,
   Roman/0000-0003-4597-9913; Holl, Reinhard/0000-0003-1395-4842;
   Baumeister, Harald/0000-0002-2040-661X
FU German Federal Ministry of Education and Research [01GL1740C]; Projekt
   DEAL
FX This study is realized as part of the joint project,Chronic Conditions
   in Adolescents: Implementation and Evaluation of Patient-centred
   Collaborative Healthcare (COACH)", funded by the German Federal Ministry
   of Education and Research (Grant No: 01GL1740C). The Federal Ministry of
   Education and Research provided feedback on the proposal of the study
   through an external peer-review process which was the basis for the
   final decision of funding the COACH-project. The funding organization
   played no role in the study design, the collection, analysis,
   interpretation of data, nor in writing the protocol. Open Access funding
   enabled and organized by Projekt DEAL.
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NR 78
TC 0
Z9 0
U1 3
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2431
J9 BMC PEDIATR
JI BMC Pediatr.
PD SEP 14
PY 2021
VL 21
IS 1
AR 404
DI 10.1186/s12887-021-02869-9
PG 13
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA UQ1JY
UT WOS:000695828600001
PM 34521358
OA Green Published, gold
DA 2022-07-18
ER

PT J
AU Khamees, D
   Kropf, CW
   Tomlinson, S
   Cranford, JA
   Carney, M
   Harvey, C
   Wolff, M
   Haas, MRC
   Hopson, LR
AF Khamees, Deena
   Kropf, Charles William
   Tomlinson, Sarah
   Cranford, James A.
   Carney, Michele
   Harvey, Carrie
   Wolff, Meg
   Haas, Mary R. C.
   Hopson, Laura R.
TI Emergency Medicine Virtual Conference Participants' Engagement with
   Competing Activities
SO WESTERN JOURNAL OF EMERGENCY MEDICINE
LA English
DT Article
ID STUDENT ENGAGEMENT; PERCEPTION; VALIDATION
AB Introduction: Residency didactic conferences transitioned to a virtual format during the COVID-19 pandemic. This format creates questions about effective educational practices, which depend on learner engagement. In this study we sought to characterize the competitive demands for learner attention during virtual didactics and to pilot methodology for future studies.
   Methods: This was a prospective, observational, cohort study of attendees at virtual didactics from a single emergency medicine residency, which employed a self-report strategy informed by validated classroom assessments of student engagement. We deployed an online, two-question survey polling across six conference days using random signaled sampling. Participants reported all activities during the preceding five minutes.
   Results: There were 1303 responses over 40 survey deployments across six nonadjacent days. Respondents were residents (63.4%); faculty (27.5%); fellows (2.3%); students (2%); and others (4.8%). Across all responses, about 85% indicated engagement in the virtual conference within the last five minutes of the polls. The average number of activities engaged in was 2.0 (standard deviation = 1.1). Additional activities included education-related (34.2%), work-related (21.1%), social (18.8%), personal (14.6%), self-care (13.4%), and entertainment (4.4%).
   Conclusion: Learners engage in a variety of activities during virtual didactics. Engagement appears to fluctuate temporally, which may inform teaching strategies. This information may also provide unique instructor feedback. This pilot study demonstrates methodology for future studies of conference engagement and learning outcomes.
C1 [Khamees, Deena] Univ Texas Houston, Dept Emergency Med, Houston, TX USA.
   [Kropf, Charles William; Cranford, James A.; Harvey, Carrie; Haas, Mary R. C.; Hopson, Laura R.] Univ Michigan, Dept Emergency Med, 1500 E Med Ctr Dr TC B1 380, Ann Arbor, MI 48109 USA.
   [Tomlinson, Sarah; Carney, Michele; Wolff, Meg] Univ Michigan, Dept Emergency Med & Pediat, Ann Arbor, MI 48109 USA.
RP Kropf, CW (通讯作者)，Univ Michigan, Dept Emergency Med, 1500 E Med Ctr Dr TC B1 380, Ann Arbor, MI 48109 USA.
EM cwkropf@med.umich.edu
OI Khamees, Deena/0000-0002-2262-9964
CR Annansingh F, 2019, EDUC INF TECHNOL, V24, P3669, DOI 10.1007/s10639-019-09949-5
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NR 19
TC 0
Z9 0
U1 0
U2 0
PU WESTJEM
PI ORANGE
PA C/O SHAHRAM LOTFIPOUR, MD, MPH, 333 CITY BLVD W STE 640, RT 128-01,
   ORANGE, CA 92868 USA
SN 1936-900X
EI 1936-9018
J9 WEST J EMERG MED
JI West. J. Emerg. Med.
PD JAN
PY 2022
VL 23
IS 1
BP 103
EP 107
DI 10.5811/westjem.2021.11.54001
PG 5
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Emergency Medicine
GA ZZ7IS
UT WOS:000773438600043
PM 35060873
OA gold, Green Published
DA 2022-07-18
ER

PT J
AU Gaganis, V
   Beckett, E
   Choate, J
   Aguilar-Roca, N
   Etherington, S
   Haigh, C
   Scott, D
   Sweeney, T
   Zubek, J
   French, M
AF Gaganis, Voula
   Beckett, Elizabeth
   Choate, Julia
   Aguilar-Roca, Nancy
   Etherington, Sarah
   Haigh, Charlotte
   Scott, Derek
   Sweeney, Terrence
   Zubek, John
   French, Michelle
TI Virtual delivery: a panacea for the financial and ethical challenges
   associated with physiology laboratory classes?
SO ADVANCES IN PHYSIOLOGY EDUCATION
LA English
DT Editorial Material
DE ethical; financial; laboratory; learning outcomes; virtual
AB There has been a gradual shift in the delivery of physiology laboratory classes over the last 30 years. For many, wet-lab demonstrations using animal tissues have been reduced or replaced with student-led investigations where students are both subjects and researchers. Despite these changes, expectations remain that physiology courses should include a practical component to encourage deeper and higher-order learning. Wet-lab tissue experiments and student-based group research formats can be expensive to run, associated with various ethical constraints, and, as discovered in these times of COVID-19, difficult to operate while adhering to physical distancing. We address the proposition that online and/or remote delivery of laboratory classes using digital technologies may provide a solution to both financial and ethical constraints of on-campus laboratory classes. Our discussions, as an international group of 10 physiologists from the United States, the United Kingdom, Canada, and Australia, revealed that although some of the financial and ethical constraints of using animal tissues and student-led investigations were addressed by the introduction of online alternatives, the construction and maintenance of online delivery modes could also be expensive and ethical issues, not previously considered, included digital equity and student data security. There was also a collective perception that if face-to-face laboratory classes were changed to an entirely virtual mode there was a risk that some intended learning outcomes would not be met. It was concluded that the "ideal" approach is likely a hybrid model whereby student attendance in face-to-face, on-campus classes is supported with interactive digital content either developed in house or obtained through third-party providers.
C1 [Gaganis, Voula] Flinders Univ S Australia, Coll Med & Publ Hlth, Bedford Pk, SA, Australia.
   [Beckett, Elizabeth] Univ Adelaide, Fac Hlth & Med Sci, Sch Biomed, Adelaide, SA, Australia.
   [Choate, Julia] Monash Univ, Dept Physiol, Clayton, Vic, Australia.
   [Aguilar-Roca, Nancy] Univ Calif Irvine, Sch Biol Sci, Irvine, CA 92717 USA.
   [Etherington, Sarah] Murdoch Univ, Discipline Med Mol & Forens Sci, Murdoch, WA, Australia.
   [Haigh, Charlotte] Univ Leeds, Sch Biomed Sci, Leeds, W Yorkshire, England.
   [Scott, Derek] Univ Aberdeen, Sch Med Med Sci & Nutr, Aberdeen, Scotland.
   [Sweeney, Terrence] Univ Scranton, Dept Biol, Scranton, PA 18510 USA.
   [Zubek, John] Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA.
   [French, Michelle] Univ Toronto, Dept Physiol, Toronto, ON, Canada.
RP Gaganis, V (通讯作者)，Flinders Univ S Australia, Coll Med & Publ Hlth, Bedford Pk, SA, Australia.
EM voula.gaganis@flinders.edu.au
OI Zubek, John/0000-0003-4079-2973; Scott, Derek
   Anthony/0000-0002-2029-6174
CR [Anonymous], 1983, TRANSPLANTATION ANAT
   Bajracharya J, 2017, INT J SCI ENG RES, V8, P1548
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NR 19
TC 0
Z9 0
U1 0
U2 1
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1043-4046
EI 1522-1229
J9 ADV PHYSIOL EDUC
JI Adv. Physiol. Educ.
PD DEC
PY 2021
VL 45
IS 4
BP 744
EP 748
DI 10.1152/advan.00242.2020
PG 5
WC Education, Scientific Disciplines; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Education & Educational Research; Physiology
GA WE2NC
UT WOS:000705461000012
PM 34529535
OA gold
DA 2022-07-18
ER

PT J
AU Quiroz, YT
   Solis, M
   Aranda, MP
   Arbaje, AI
   Arroyo-Miranda, M
   Cabrera, LY
   Carrasquillo, MM
   Corrada, MM
   Crivelli, L
   Diminich, ED
   Dorsman, KA
   Gonzales, M
   Gonzalez, HM
   Gonzalez-Seda, AL
   Grinberg, LT
   Guerrero, LR
   Hill, CV
   Jimenez-Velazquez, IZ
   Guerra, JJL
   Lopera, F
   Maestre, G
   Medina, LD
   O'Bryant, S
   Penaloza, C
   Pinzon, MM
   Mavarez, RVP
   Pluim, CF
   Raman, R
   Rascovsky, K
   Rentz, DM
   Reyes, Y
   Rosselli, M
   Tansey, MG
   Vila-Castelar, C
   Zuelsdorff, M
   Carrillo, M
   Sexton, C
AF Quiroz, Yakeel T.
   Solis, Michele
   Aranda, Maria P.
   Arbaje, Alicia I.
   Arroyo-Miranda, Mirna
   Cabrera, Laura Y.
   Carrasquillo, Minerva Maria
   Corrada, Maria M.
   Crivelli, Lucia
   Diminich, Erica D.
   Dorsman, Karen A.
   Gonzales, Mitzi
   Gonzalez, Hector M.
   Gonzalez-Seda, Ana L.
   Grinberg, Lea T.
   Guerrero, Lourdes R.
   Hill, Carl V.
   Jimenez-Velazquez, Ivonne Z.
   Guerra, Jorge J. Llibre
   Lopera, Francisco
   Maestre, Gladys
   Medina, Luis D.
   O'Bryant, Sid
   Penaloza, Claudia
   Pinzon, Maria Mora
   Mavarez, Rosa V. Pirela
   Pluim, Celina F.
   Raman, Rema
   Rascovsky, Katya
   Rentz, Dorene M.
   Reyes, Yarissa
   Rosselli, Monica
   Tansey, Malu Gamez
   Vila-Castelar, Clara
   Zuelsdorff, Megan
   Carrillo, Maria
   Sexton, Claire
TI Addressing the disparities in dementia risk, early detection and care in
   Latino populations: Highlights from the second Latinos & Alzheimer's
   Symposium
SO ALZHEIMERS & DEMENTIA
LA English
DT Review; Early Access
ID BILINGUALISM; PREVALENCE; DISEASE
AB The Alzheimer's Association hosted the second Latinos & Alzheimer's Symposium in May 2021. Due to the COVID-19 pandemic, the meeting was held online over 2 days, with virtual presentations, discussions, mentoring sessions, and posters. The Latino population in the United States is projected to have the steepest increase in Alzheimer's disease (AD) in the next 40 years, compared to other ethnic groups. Latinos have increased risk for AD and other dementias, limited access to quality care, and are severely underrepresented in AD and dementia research and clinical trials. The symposium highlighted developments in AD research with Latino populations, including advances in AD biomarkers, and novel cognitive assessments for Spanish-speaking populations, as well as the need to effectively recruit and retain Latinos in clinical research, and how best to deliver health-care services and to aid caregivers of Latinos living with AD.
C1 [Quiroz, Yakeel T.; Pluim, Celina F.; Vila-Castelar, Clara] Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA 02115 USA.
   [Aranda, Maria P.] USC Roybal Inst Aging, Los Angeles, CA USA.
   [Aranda, Maria P.] Johns Hopkins Sch Med, Div Geriatr Med & Gerontol, Baltimore, MD USA.
   [Aranda, Maria P.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Baltimore, MD USA.
   [Arroyo-Miranda, Mirna] Univ Houston, Dept Psychol, Houston, TX USA.
   [Cabrera, Laura Y.] Penn State Univ, Dept Engn Sci & Mech, 227 Hammond Bldg, University Pk, PA 16802 USA.
   [Carrasquillo, Minerva Maria] Mayo Clin Florida, Jacksonville, FL USA.
   [Corrada, Maria M.] Univ Calif Irvine, Irvine, CA USA.
   [Crivelli, Lucia] Fleni, Dept Cognit Neurol, Buenos Aires, DF, Argentina.
   [Diminich, Erica D.] Renaissance Sch Med, Stony Brook, NY USA.
   [Dorsman, Karen A.] Univ Texas Southwestern Med Ctr Dallas, Dallas, TX 75390 USA.
   [Gonzales, Mitzi] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
   [Gonzalez, Hector M.] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA.
   [Gonzalez-Seda, Ana L.; Hill, Carl V.; Reyes, Yarissa; Carrillo, Maria; Sexton, Claire] Alzheimers Assoc, Chicago, IL 60601 USA.
   [Grinberg, Lea T.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Guerrero, Lourdes R.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.
   [Jimenez-Velazquez, Ivonne Z.] Univ Puerto Rico, Sch Med, Med Dept, Med Sci Campus, San Juan, PR 00936 USA.
   [Guerra, Jorge J. Llibre] Washington Univ, Sch Med St Louis, St Louis, MO 63110 USA.
   [Lopera, Francisco] Univ Antioquia, Neurosci Grp Antioquia, Medellin, Colombia.
   [Maestre, Gladys] Univ Texas Rio Grande Valley, Edinburg, TX USA.
   [Medina, Luis D.] Univ Houston, Houston, TX USA.
   [O'Bryant, Sid] Univ North Texas, Hlth Sci Ctr, Ft Worth, TX USA.
   [Penaloza, Claudia] Univ Barcelona, Dept Cognit Dev & Educ Psychol, Barcelona, Spain.
   [Pinzon, Maria Mora] Univ Wisconsin, Dept Family Med & Community Hlth, Madison, WI USA.
   [Pinzon, Maria Mora] Univ Wisconsin, Wisconsin Alzheimers Inst, Madison, WI USA.
   [Mavarez, Rosa V. Pirela] Univ Texas Rio Grande Valley, Sch Med, Dept Human Genet, Edinburg, TX USA.
   [Mavarez, Rosa V. Pirela] Univ Texas Rio Grande Valley, Sch Med, Rio Grande Valley Alzheimers Dis Resources Ctr Mi, Edinburg, TX USA.
   [Raman, Rema] Univ Southern Calif, Alzheimers Therapeut Res Inst, San Diego, CA USA.
   [Rascovsky, Katya] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA.
   [Rentz, Dorene M.] Harvard Med Sch, Boston, MA 02115 USA.
   [Rosselli, Monica] Florida Atlantic Univ, Dept Psychol, Boca Raton, FL 33431 USA.
   [Tansey, Malu Gamez] Univ Florida, Gainesville, FL USA.
   [Zuelsdorff, Megan] Univ Wisconsin, Sch Nursing, Madison, WI USA.
   [Zuelsdorff, Megan] Wisconsin Alzheimers Dis Res Ctr, Madison, WI USA.
RP Sexton, C (通讯作者)，Alzheimers Assoc, Chicago, IL 60601 USA.
EM csexton@alz.org
RI Peñaloza, Claudia/M-2122-2019
OI Peñaloza, Claudia/0000-0003-1200-5936; corrada,
   maria/0000-0002-8168-8593
FU US National Institute on Aging [R01AG054671, R01AG066823]; National
   Institute on Aging [5P 50AG005142, 2P 30AG043073, 5R13AG063477,
   1U54AG063546-01, R44AG060855, U19NS120384, U24 AG059624, R56 AG048642,
   RF1 AG054548, RF1 AG061022, P30 AG062429, 1 R13 AG 063477 -01];
   Alzheimer's Disease Program [19-10538]; Unidos en el Cuidado: The Savvy
   Caregiver: Translation, Transformation, and Feasibility of
   Evidenced-Based Program for Dementia Caregivers [011069-00001]; A
   Program for Families Caring for a Loved One with Dementia (Savvy
   Caregiver Program) [12-2602-3600]; NIH [R21TW010896 -12/201911/2020, P30
   AG059300-01, 08/201806/2020, R24AG065170, R01AG063689, U24AG057437,
   5R01AG061848, 5R01AG054029]; Alzheimer's Association [AACSF-20-682140,
   SG-20-690363, 2019-AARGD-642445, 2019-AARF-644631]; NIH/National
   Institute on Aging [AG04995305, R01:AG049953]; Alzheimer's Association
   Part of the Cloud Gates grant [PTCG-20-695184]; Alzheimer's Drug
   Discovery Foundation [GC201908-2019443]; Texas Alzheimer's Research and
   Care Consortium [2018-28-81-J1]; Juan de la Cierva-Incorporacion Program
   - Ministerio deCiencia e Innovacion, Agencia Estatal de Investigacion
   [IJC2018-037818, MCIN/AEI 10.13039/501100011033]; Boston University
   under NIH/NIDCD [U01DC014922]; NIH/NCATS [1UL1TR002373]; Health
   Resources and Services Administration [T32HP10010];  [AARF18562958]; 
   [1R03AG063303]
FX Yakeel T. Quiroz, in the past 36 months, reports grants or contracts
   from the US National Institute on Aging (R01AG054671, R01AG066823),
   Alzheimer's Association, MGHECOR; consulting fees from Biogen; payment
   or honoraria for seminars, academic rounds; has served as past chair of
   the ISTAART Diversity and Disparities PIA; and holds a role as chair of
   the International Neuropsychological Society Teleneuropsychology Special
   Interest Group. Maria P. Aranda, in the past 36 months, reports grants
   or contracts: CoInvestigator and Director, Outreach, Recruitment and
   Engagement Core (ORE), USC Alzheimer's Disease Research Center; National
   Institute on Aging (5P 50AG005142); Co-Investigator and Lead, Research
   Education Core (REC), USC Research Center on Alzheimer's
   Disease-Minority Aging Research (AD-RCMAR); National Institute on Aging
   (2P 30AG043073); Principal Investigator, SoCal Savvy, State of
   California, Department of Public Health, Alzheimer's Disease Program
   (19-10538); Principal Investigator, Unidos en el Cuidado: The Savvy
   Caregiver: Translation, Transformation, and Feasibility of
   Evidenced-Based Program for Dementia Caregivers (011069-00001); Project
   Subaward: Alzheimer's Los Angeles; Principal Investigator,
   Interdisciplinary Aging Research to Address Health Disparities in
   Alzheimer's Disease and Related Dementias; National Institute on
   Aging(5R13AG063477); Co-Investigator, NIA AD/ADRD Health Care Systems
   Research Collaboratory, IMPACT Collaboratory, National Institute on
   Aging (1U54AG063546-01); 2019-20 Consultant, Health Equity Team (HET);
   NIA AD/ADRD Health Care Systems Research Collaboratory, National
   Institute on Aging (1U54AG063546-01); 2017 Principal Investigator, A
   Program for Families Caring for a Loved One with Dementia (Savvy
   Caregiver Program) (12-2602-3600); Research Council, USC Suzanne
   Dworak-Peck School of SocialWork, Los Angeles, CA; 2017 Principal
   Investigator, Establishing Rates of Caregiving to Adults with Physical
   and Cognitive Disabilities in Home-and Community-Based Services; St.
   Barnabas Senior Services & AARP, Los Angeles, CA. MPA also received
   consulting fees for Avanir Pharmaceuticals, served as Chair, Caregiver
   Advisory Board-one time and is a member of the External Advisory Board,
   San Diego Alzheimer's Disease Resource Center for Minority Aging
   Research. Alicia I. Arbaje, in the past 36 months, reports grants from
   AHRQ, NIA, JHAD-RCMAR; received payment or honoraria for lecture from
   HealtheNetwork; participated on a DSMB or Advisory Board for a
   Vanderbilt University study. Mirna Arroyo-Miranda received support for
   attending meetings and/or travel to ISTAART Diversity PIA Day at AAIC
   2019, with a Travel Fellowship Award from the Alzheimer's Association.
   Laura Y.; Cabrera, in the past 36 months, reports grants or contracts
   from NIH Bioethics supplement R21TW010896 -12/201911/2020, P30
   AG059300-01 Alzheimer's related Resource Centers for Minority Aging
   Research (ADRCMAR)-Latinos Perceptions and Concerns about Alzheimer
   Disease (MCCFAD Pilot 2) -08/201806/2020; received honoraria for
   lectures: 2018 Michigan Academy of Nutrition and Dietetics Annual
   Meeting and honoraria for presentations: 2018 OECD "Minding
   Neurotechnology: Delivering Responsible Innovation for Health and
   Well-being", 2019-Keynote presentation at Markkula Center for Applied
   Ethics at Santa Clara University, 2019-honoraria as panelist for the
   Michigan State University CommSciCom; received support for travel
   2019-attendance to GSA; and held role as board member for International
   Neuroethics Society and chair for IEEE Brain Neuroethics Subcommittee.
   Minerva Maria Carrasquillo received funding for research from NIH
   grants; received honoraria for serving as reviewer for NIH grants. Maria
   M. Corrada, in the past 36 months, reports grants from NIA; received
   payment or honoraria for grant reviews and for participation in a
   mentoring program; received support for attending meetings and/or travel
   from the Alzheimer's Association and NIA grants; participated on NIA
   organized DSB for a blood pressure lowering pragmatic trial; held a
   leadership or fiduciary role at Alzheimer's and Dementia journal
   editorial board; and is a member of the Alzheimer's Association
   International Conference Scientific Program Committee. Lucia Crivelli,
   in the past 36 months, reports grants or contracts from the Alzheimer's
   Association for the LatAm FINGERS project; and received support for a
   travel fellowship from the Alzheimer's Association for AAIC 2021. Erica
   D. Diminich, in the past 36 months, reports grants from Alzheimer's
   Association AACSF-20-682140; NIH/National Institute on Aging AG04995305
   Diversity Supplement Award (under R01:AG049953). Karen A. Dorsman
   received a small scholarship as a student; received financial support (1
   hotel night) to attend the Texas Alzheimer's Research and Care
   Consortium (TARCC) meeting in 2020; held or holds a leadership or
   fiduciary roles as a Student Representative-Elect for the Hispanic
   Neuropsychological Society (unpaid, non-voting Board member)
   2021-present, Ad Hoc Advisor to the Nicaraguan Alzheimer's Foundation
   (unpaid) 2019-present, Latino Advisory Group member to the Alzheimer's
   Association, Northern California & Northern Nevada chapter 2018-2019.
   Mitzi Gonzales, in the past 36 months, reports grants or contracts from
   Alzheimer's Association Part of the Cloud Gates grant (PTCG-20-695184),
   NIA (R44AG060855, U19NS120384, U24 AG059624), the Alzheimer's Drug
   Discovery Foundation (GC201908-2019443), Texas Alzheimer's Research and
   Care Consortium (2018-28-81-J1); received support for attending
   Alzheimer's Association International Conference Travel Fellowship 2021.
   Hector M. Gonzalez, in the past 36 months, reports grants or contracts
   from National Institute on Aging (R56 AG048642, RF1 AG054548, RF1
   AG061022, P30 AG062429). Ana L. Gonzalez-Seda held a leadership or
   fiduciary role at Office of Health Equity with the California Department
   of Public Health and City Heights Community Development Corporation. Lea
   T.; Grinberg, in the past 36 months, reports grants or contracts from
   NIH several r01s, K24 and R01, Tau consortium, Weill Neurohub; received
   consulting fees from CuraSen Inc; received payment or honoraria
   fromZydusPharmaceuticals 2021; received support for attending meetings
   and/or travel from Alzheimer Association, Tau Consortium, CONy. Lourdes
   Guerrero has nothing to disclose. Carl V. Hill, in the past 36 months,
   reports grants from National Institutes of Health; and held unpaid roles
   with advisory groups dedicated toDiversity, Equity and Inclusion at
   various academic and non-profit institutions. Ivonne Z.
   Jimenez-Velazquez has nothing to disclose. Jorge J. Llibre Guerra
   received research funding from the Alzheimer Association (SG-20-690363).
   Francisco Lopera, in the past 36 months, reports grants from NIA,
   Banner, and Roche, API Colombia grant, NIH: Colbos Grant; and received
   support for attending meetings and/or travel from Red Lat, San Francisco
   California. Gladys Maestre, in the past 36 months, reports grants from
   National Institute on Aging/National Institutes of Health and Texas
   Alzheimer's Research and Care Consortium; received payment or honoraria
   as a reviewer for NIH; held a leadership or fiduciary role at Funda
   conciencia and Appremed. Luis D. Medina, in the past 36 months, reports
   grants or contracts from National Institutes of Health R24AG065170
   (Medina) Jan 2020-Nov 2023, Alzheimer's Association 2019-AARGD-642445
   (Medina) Feb 2020Jan 2023; received honoraria for lectures fromUCSD,
   UMass Amherst; received support to attend AAIC 2021 as member of
   Alzheimer's Association International Research Grant Program Council.
   Sid O'Bryant, in the past 36 months, reports grants or contracts from
   NIH/NIA, Alzheimer's Association, MJFF, Cx Precision Medicine; and
   receives royalties from licensed patents. SO'B is the founding scientist
   from Cx Precision Medicine; holds multiple patents in precision medicine
   for neurodegenerative diseases; and is the founding scientist of Cx
   Precision Medicine and holds stocks. Claudia Penaloza is supported by
   the Juan de la Cierva-Incorporacion Program (IJC2018-037818) funded by
   Ministerio deCiencia e Innovacion, Agencia Estatal de Investigacion
   MCIN/AEI 10.13039/501100011033. CP was employed by Boston University
   under NIH/NIDCD grant number U01DC014922 during the 24 previous months
   (January 2017-August 2020) and is currently a research consultant for
   that institution. Maria Mora Pinzon, in the past 36months, reports
   grants or contracts from Increasing Latinx participation in ADRD through
   a Community-Based Approach. Wisconsin Alzheimer's Disease Research
   Center (ADRC) Research Education Component ("REC") Scholar; Pisando
   Fuerte Online Adapting to COVID-19, University of Wisconsin Institute
   for Clinical and Translational ResearchDissemination and Implementation
   Launchpad; Leveraging social networks and trusted community influencers
   to disseminate an accurate and up-to-date understanding of COVID-19 in
   Black, Latinx and American Indian Communities. Wisconsin Partnership
   Program(WPP); Beliefs and Attitudes about Dementia among Latinx
   Individuals Living in Dane County -Validation of a Survey Instrument.
   Department of Medicine, University of Wisconsin -Madison; Pisando
   Fuerte: a fall prevention program for Spanish speaking seniors,
   Retirement Research Foundation (RRF); Pisando Fuerte: a fall prevention
   program for Spanish speaking seniors. University of Wisconsin -Institute
   for Clinical and Translational Research (UW -ICTR).; This project was
   supported in part by grant 1UL1TR002373 to UW ICTR from NIH/NCATS; was
   supported by the University of Wisconsin Department of Family Medicine
   and Community Health Primary Care Research Fellowship, funded by grant
   T32HP10010 from the Health Resources and Services Administration;
   received support for attending meetings and/or travel 2020
   -NIDDK/National Hispanic Medical Association Travel Award -Cancelled due
   to COVID19; serves as President-Elect Medical Organization for the
   Latino Advancement -Wisconsin, Inc. (2021); was selected as an emerging
   scholar in the scientific training program, Interdisciplinary Aging
   Research to Address Health Disparities in Alzheimer's Disease and
   Related Dementias, USC Edward R. Roybal Institute on Aging, Los Angeles,
   CA. Funding for the scientific training program was made possible in
   part by 1 R13 AG 063477 -01 from the National Institute on Aging. Rosa
   V. Pirela Mavarez has nothing to disclose. Celina F. Pluim has nothing
   to disclose. Rema Raman received grant funding from the National
   Institutes of Health (R01AG063689; U24AG057437, 5R01AG061848,
   5R01AG054029), Alzheimer's Association, Eli Lilly, and Eisai Inc.; she
   is the Vice-Chair of the Board of the Alzheimer's Association's San
   Diego/Imperial chapter. Katya Rascovsky, in the past 36 months, reports
   grants or contracts from NIH. Dorene M. Rentz in the past 36months,
   received consulting fees from Neurotrack andDigital Cognition
   Technologies; received payment or honoraria for ACTC IMPACT AD Course as
   faculty for presentations and group leadership activities and received
   support for attending ACTC Meeting in February 2020. Yarissa Reyes has
   nothing to disclose. Monica Rosselli, in the past 36 months, reports
   grants from the Alzheimer Disease Research Center. National Institutes
   of Health/National Institute of Aging, PI: T Golden & R Duara; Co-I: M.
   Rosselli (2015-2020.; Cognitive Support Strategies to Improve Medication
   Adherence in Older Adults Undergoing Hemodialysis, Keryx Pharmaceitics,
   PI: D Hain. CoI: M. Rosselli. (2019-2021); Neuro-imaging, and Sensitive
   Novel Cognitive Measures in Detection of Early Alzheimer's Disease in
   Bilingual and Monolingual Hispanic Americans, Florida Department of
   HealthEd and Ethel Moore Alzheimer's Disease Research Program, PI: M
   Rosselli (2019-2021); Fit2Drive: Development and Testing of a Driver
   Risk Predictor for Individuals with AD Florida Department of HealthEd
   and Ethel Moore Alzheimer's Disease Research Program, PI Tappen. Co-I:
   M. Rosselli; Communication of Dementia Diagnoses: Investigating Patient,
   Family, and Physician Experiences and Developing Best Practices. Florida
   Department of Health-Ed and Ethel Moore Alzheimer's Disease Research
   Program, PI: M. Amstrong (UF). CoI M. Rosselli (2020 -2023); In-Vehicle
   Sensors to Detect Cognitive Change in Older Drivers. National Institutes
   of Health. National Institute of Aging, PI: R. Tappen. Co-I: M.
   Rosselli; Florida Alzheimer's Disease Research Center. National
   Institutes of Health. National Institute of Aging, PI. T.Golde (UF).
   Co-I: M. Rosselli (2020-2025); Postdoctoral Research Fellowship in
   Neuropsychology and Brain Biomarkers of Abnormal Aging Florida
   Department of Health-Ed and Ethel Moore Alzheimer's Disease Research
   Program, PI: M Rosselli.; Malu Gamez Tansey, in the past 36 months,
   reports grants or contracts from NIH, MJFF, Parkinson's Foundation;
   received consulting fees from INmune Bio, Cerebral Therapeutics;
   received multiple support for attending meetings and/or travel;
   participated on a DSMB or Advisory Board for MSAG, Weston Family
   Foundation; has held/holds stock or stock options at INmune bio. Clara
   Vila-Castelar receives funding from the Alzheimer's Association
   (2019-AARF-644631); co-chairs the Sex Differences Special Interest
   Group, Diversity andDisparities Professional Interest Area-PIA of the
   International Society to Advance Alzheimer's Research and Treatment
   (ISTAART). Megan Zuelsdorff, in the past 36 months, reports grants
   AARF18562958 -Psychosocial stressors, allostatic load, and cognitive
   aging; 1R03AG063303 (Zuelsdorff)-Socialbiological dimensions of ADRD
   risk and resilience in a Native American cohort; held/holds a leadership
   or fiduciary role at Wisconsin Alzheimer's Institute Leadership Board
   and ISTAART Diversity & Disparities Executive Committee. Maria Carrillo
   is a full-time employee of the Alzheimer's Association and reports, in
   the past 36 months, participating on a Data Safety Monitoring Board or
   Advisory Board for US POINTER and holding a role for EASTERSEALS. Claire
   Sexton is a full-time employee of the Alzheimer's Association and, in
   the past 36 months, reports consultation fees from Jazz Pharmaceuticals
   and support for attending meetings and/or travel to the AAIC Satellite
   Symposium Sydney (2019) and Society for the Study of Ingestive Behavior
   (SSIB) Annual Meeting (2019) and reports an unpaid role as a trustee of
   Dementia Adventure (2018-2020).
CR Babulal GM, 2019, ALZHEIMERS DEMENT, V15, P292, DOI 10.1016/j.jalz.2018.09.009
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NR 36
TC 0
Z9 0
U1 7
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-5260
EI 1552-5279
J9 ALZHEIMERS DEMENT
JI Alzheimers. Dement.
DI 10.1002/alz.12589
EA FEB 2022
PG 10
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA ZG5EZ
UT WOS:000760282200001
PM 35199931
OA hybrid
DA 2022-07-18
ER

PT J
AU Craddock, N
   Garbett, KM
   Haywood, S
   Nasution, K
   White, P
   Saraswati, LA
   Rizkiah, C
   Medise, BE
   Diedrichs, PC
AF Craddock, Nadia
   Garbett, Kirsty M.
   Haywood, Sharon
   Nasution, Kholisah
   White, Paul
   Saraswati, L. Ayu
   Rizkiah, Chairunnisa
   Medise, Bernie E.
   Diedrichs, Phillippa C.
TI 'Dove Confident Me Indonesia: Single Session': study protocol for a
   randomised controlled trial to evaluate a school-based body image
   intervention among Indonesian adolescents
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Body image; Indonesia; Southeast Asia; Low- and middle-income countries;
   Single-session intervention; School-based intervention; Adolescent
   mental health; Randomised controlled trial; Study protocol; Life skills
   education
ID EATING-DISORDERS; DISSATISFACTION; HEALTH; WEIGHT; SCALE; ASSOCIATIONS;
   METAANALYSIS; RELIABILITY; APPEARANCE; PREVENTION
AB Background: Due to the prevalence and associated adverse health consequences of negative body image among adolescents globally, there is a need to develop acceptable, effective, and scalable interventions. School-based body image interventions delivered by trained teachers show promise in reducing negative body image in adolescents. However, there is currently a lack of evidenced-based body image interventions for use in low- and middle-income countries (LMICs). This paper outlines a protocol for the development and evaluation of Dove Confident Me Indonesia: Single Session, a single-session, teacher-led body image intervention for Indonesian adolescents.
   Method: The effectiveness of the intervention will be evaluated using a cluster randomised controlled trial design. Due to the COVID-19 pandemic, the trial will be conducted online. Trained teachers or school guidance counsellors will deliver the intervention. Self-report questionnaires will be collected at three time points: baseline, post-intervention, and two-month follow-up. The primary outcome is body esteem. Secondary outcomes are internalisation of appearance ideals, mood, engagement in life activities, tendency to engage in appearance comparisons, and skin shade satisfaction. A minimum of 1000 participants will provide 95% power to detect small-to-medium intervention effects. To account for attrition and potential internet issues, the sample will comprise of 2000 Indonesian adolescents in grades 7-9, attending state junior high schools in Surabaya, East Java. Quantitative and qualitative data on acceptability of the intervention will also be collected from teachers and students. Additionally, fidelity of lesson implementation will be assessed. This project received ethical approval from the Universitas Indonesia and the University of the West of England. The intervention will be disseminated in junior high schools throughout Indonesia via UNICEF's Life Skills Education (LSE) programme, which will be freely available for teachers to download.
   Discussion: This paper presents Dove Confident Me Indonesia: Single Session, a culturally adapted school-based intervention designed to improve Indonesian adolescents' body image. It details the plan for evaluation, highlighting the strengths and limitations of the proposed study design. It will be informative for others aiming to adapt evidence-based school curricula to promote well-being among adolescents in LMICs.
C1 [Craddock, Nadia; Garbett, Kirsty M.; Haywood, Sharon; White, Paul; Diedrichs, Phillippa C.] Univ West England, Ctr Appearance Res, Coldharbour Lane, Bristol BS16 1QY, Avon, England.
   [Nasution, Kholisah; Medise, Bernie E.] Univ Indonesia, Fac Med, Jakarta, Indonesia.
   [Saraswati, L. Ayu] Univ Hawaii Manoa, Honolulu, HI 96822 USA.
   [Rizkiah, Chairunnisa] Lazuardi Al Falah Depok Jr High Sch Indonesia, Kota Depok, Indonesia.
RP Craddock, N (通讯作者)，Univ West England, Ctr Appearance Res, Coldharbour Lane, Bristol BS16 1QY, Avon, England.
EM Nadia.Craddock@uwe.ac.uk
OI Craddock, Nadia/0000-0002-1403-9550; Haywood, Sharon/0000-0003-0761-5406
FU Dove Self-Esteem Project (Unilever)
FX This study was funded by a resYearch grant from the Dove Self-Esteem
   Project (Unilever). The funders had no role in data analysis, decision
   to publish, or manuscript preparation. The Dove Self-Esteem Project
   (Unilever) was permitted to review the manuscript and suggest changes,
   but the authors exclusively retained the final decision on content. The
   views expressed are those of the authors and not necessarily those of
   Unilever.
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NR 69
TC 0
Z9 0
U1 4
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD NOV 16
PY 2021
VL 21
IS 1
AR 2102
DI 10.1186/s12889-021-11770-0
PG 20
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA WY5NW
UT WOS:000719326400001
PM 34784916
OA Green Published, gold
DA 2022-07-18
ER

PT J
AU Youssef, D
   Berry, A
   Youssef, J
   Abou-Abbas, L
AF Youssef, Dalal
   Berry, Atika
   Youssef, Janet
   Abou-Abbas, Linda
TI Vaccination against influenza among Lebanese health care workers in the
   era of coronavirus disease 2019
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Health care workers; Influenza vaccination; Coronavirus disease 2019;
   Knowledge; Attitudes; Practices
ID KNOWLEDGE; ADULTS
AB Background Health-care workers (HCWs) are at a higher occupational risk of contracting and transmitting influenza. Annual vaccination is an essential tool to prevent seasonal influenza infection. However, HCWs vaccine hesitancy remains a leading global health threat. This study aims to evaluate the flu vaccination coverage rates among Lebanese HCWs and to assess their knowledge, attitudes, practices, perceived barriers, and benefits toward the flu vaccine during the COVID-19 pandemic. In addition, we sought to identify the factors associated with flu vaccine uptake. Methods A cross-sectional study using an online survey was conducted in Lebanon among HCWs between 14 and 28 October 2020. Multivariable logistic regression was carried out to identify the factors associated with influenza vaccine uptake. Results A total of 560 HCWs participated in the survey of whom 72.9% were females, and 53.9% were aged between 30-49 years. Regarding Flu vaccination uptake, the rate has risen from 32.1% in 2019-2020 to 80.2% in 2020-2021 flu season. The majority of HCWs had a good knowledge level and a positive attitude toward flu vaccination. Regarding their practices, less than 50% of HCW were currently promoting the importance of getting the flu vaccine. The majority (83.3%) ranked the availability of a sufficient quantity of vaccines as the most significant barrier to flu vaccination. The main perceived flu vaccination benefits were enhancing patient safety, minimizing the viral reservoir in the population, decreasing hospital admission, and avoiding influenza and COVID-19 co-infection. The odds of influenza vaccine uptake was lower in unmarried compared to married HCWs (OR = 0.527, CI (0.284-0.978). However, HCWs having received the influenza vaccine in the previous season (OR = 6.812, CI (3.045-15.239)), those with good knowledge level (OR = 3.305, CI (1.155-9.457)), low perceived barriers (OR = 4.130, CI (1.827-9.334)) and high perceived level of the benefits (OR = 6.264, CI (2.919-13.442)) of the flu vaccination were found more prone to get the flu vaccine. Conclusion Flu vaccination uptake has increased among HCWs during the 2020-2021 flu season compared with the previous one. Continuing education as well as ensuring free, equitable, and convenient access to vaccination are still required to increase the annual flu vaccination uptake among HCWs.
C1 [Youssef, Dalal; Berry, Atika] Minist Publ Hlth, Prevent Med Dept, Beirut, Lebanon.
   [Youssef, Dalal] Bordeaux Univ, Inst Sante Publ Epidemiol & Dev ISPED, Bordeaux, France.
   [Youssef, Janet] Al Zahraa Hosp Univ, Med Ctr, Beirut, Lebanon.
   [Abou-Abbas, Linda] Lebanese Univ, Fac Med Sci, Neurosci Res Ctr, Beirut, Lebanon.
RP Youssef, D (通讯作者)，Minist Publ Hlth, Prevent Med Dept, Beirut, Lebanon.; Youssef, D (通讯作者)，Bordeaux Univ, Inst Sante Publ Epidemiol & Dev ISPED, Bordeaux, France.
EM dalalyoussefesu@gmail.com
RI Youssef, Dalal/ABG-8703-2021; Abou Abbas, Linda/U-6802-2017
OI Youssef, Dalal/0000-0003-3085-6849; Abou Abbas,
   Linda/0000-0001-9185-3831
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NR 29
TC 1
Z9 1
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JAN 18
PY 2022
VL 22
IS 1
AR 120
DI 10.1186/s12889-022-12501-9
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA YJ2EJ
UT WOS:000744348200001
PM 35039009
OA Green Published, gold
DA 2022-07-18
ER

PT J
AU Naveed, QN
   Alam, MM
   Qahmash, AI
   Quadri, KM
AF Naveed, Quadri Noorulhasan
   Alam, Mohammad Mahtab
   Qahmash, Adel Ibrahim
   Quadri, Kahkasha Moin
TI Exploring the Determinants of Service Quality of Cloud E-Learning System
   for Active System Usage
SO APPLIED SCIENCES-BASEL
LA English
DT Article
DE cloud E-Learning system; cloud E-Learning education; cloud E-Learning
   services; quality of cloud E-Learning services; active system usage
ID TECHNOLOGY ACCEPTANCE MODEL; SUCCESS; FRAMEWORK; PERCEPTIONS; SCALE
AB E-Learning through a cloud-based learning management system, with its various added advantageous features, is a widely used pedagogy at educational institutions in general and more particularly during and post Covid-19 period. Successful adoption and implementation of cloud E-Learning seems difficult without significant service quality. Aims: This study aims to identify the determinant of cloud E-Learning service quality. Methodology: A theoretical model was proposed to gauge the cloud E-Learning service quality by extensive literature search. The most important factors for cloud E-Learning service quality were screened. Instruments for each factor were defined properly, and its content validity was checked with the help of Group Decision Makers (GDMs). Empirical testing was used to validate the proposed theoretical model, the self-structured closed-ended questionnaire was used to conduct an online survey. Findings: Internal consistency of the proposed model was checked with reliability and composite reliability and found appropriate alpha >= 0.70 and CR >= 0.70. Indicator Reliability was matched with the help of Outer Loading and found deemed fit OL >= 0.70. To establish Convergent Validity Average Variance Extracted, Factor Loading and Composite Reliability were used and found deemed suitable with AVE >= 0.50. The HTMT and Fornell-Lacker tests were applied to assess discriminant validity and found appropriate (HTMT <= 0.85). Finally, the Variance Inflation Factor was used to detect multicollinearity if any and found internal and external VIF < 3. Conclusions: Theoretical model for cloud E-Learning service quality was proposed. Information Quality, Reliability, Perceived ease of use and Social Influence were considered as explanatory variables whereas actual system usage was the dependent variable. Empirical testing on all parameters stated that the proposed model was deemed fit in evaluating cloud E-Learning service quality.
C1 [Naveed, Quadri Noorulhasan] King Khalid Univ, Coll Comp Sci, Abha 62529, Saudi Arabia.
   [Alam, Mohammad Mahtab] King Khalid Univ, Coll Appl Med Sci, Abha 62529, Saudi Arabia.
   [Qahmash, Adel Ibrahim] King Khalid Univ, Coll Educ, Abha 62529, Saudi Arabia.
   [Quadri, Kahkasha Moin] Dr Babasaheb Ambedkar Marathwada Univ, Dept English, Aurangabad 431004, Maharashtra, India.
RP Naveed, QN (通讯作者)，King Khalid Univ, Coll Comp Sci, Abha 62529, Saudi Arabia.
EM qnaveed@kku.edu.sa; mmalam@kku.edu.sa; aqahmash@kku.edu.sa;
   kmquadri@gmail.com
OI ALAM, MOHAMMAD MAHTAB/0000-0003-3966-6988; Quadri, Kahkasha
   Moin/0000-0003-2551-1643; , Quadri Noorulhasan
   Naveed/0000-0003-2757-4138
FU Deanship of Scientific Research at King Khalid University [RGP,
   1/370/42]
FX The authors extend their appreciation to the Deanship of Scientific
   Research at King Khalid University for funding and support of this work
   under Research grant award number RGP. 1/370/42.
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NR 55
TC 5
Z9 5
U1 5
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3417
J9 APPL SCI-BASEL
JI Appl. Sci.-Basel
PD MAY
PY 2021
VL 11
IS 9
AR 4176
DI 10.3390/app11094176
PG 18
WC Chemistry, Multidisciplinary; Engineering, Multidisciplinary; Materials
   Science, Multidisciplinary; Physics, Applied
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Chemistry; Engineering; Materials Science; Physics
GA SB3ND
UT WOS:000649904600001
OA Green Published
DA 2022-07-18
ER

PT J
AU Jackson, SL
   Shucard, H
   Liao, JM
   Bell, SK
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   Leveille, S
   Walker, J
   Elmore, JG
AF Jackson, Sara L.
   Shucard, Hannah
   Liao, Joshua M.
   Bell, Sigall K.
   Fossa, Alan
   Payne, Thomas H.
   Reisch, Lisa M.
   Radick, Andrea C.
   DesRoches, Catherine M.
   Fitzgerald, Patricia
   Leveille, Suzanne
   Walker, Jan
   Elmore, Joann G.
TI Care partners reading patients' visit notes via patient portals:
   Characteristics and perceptions
SO PATIENT EDUCATION AND COUNSELING
LA English
DT Article
DE Health information technology; Electronic health records; Care partner;
   Consumer health information; Health literacy
ID FAMILY CAREGIVERS; HEALTH; STRESS; BURDEN
AB Background: Care partners are key members of patients' health care teams, yet little is known about their experiences accessing patient information via electronic portals. Objective: To better understand the characteristics and perceptions of care partners who read patients' electronic visit notes. Patient involvement: Focus groups with diverse patients from a community health center provided input into survey development. Methods: We contacted patient portal users at 3 geographically distinct sites in the US via email in 2017 for an online survey including open ended questions which we qualitatively analyzed. Results: Respondents chose whether to answer as care partners (N = 874) or patients (N = 28,782). Among care partner respondents, 44% were spouses, 43% children/other family members, and 14% friends/neighbors/other. Both care partners and patients reported that access to electronic notes was very important for promoting positive health behaviors, but care partners' perceptions of importance were consistently more positive than patients' perceptions of engagement behaviors. Open-ended comments included positive benefits such as: help with remembering the plan for care, coordinating care with other doctors, decreasing stress of care giving, improving efficiency of visits, and supporting patients from a geographical distance. They also offered suggestions for improving electronic portal and note experience for care partners such as having a separate log on for care partners; having doctors avoid judgmental language in their notes; and the ability to prompt needed medical care for patients. Discussion: Care partners value electronic access to patients' health information even more than patients. The majority of care partners were family members, whose feedback is important for improving portal design that effectively engages these care team members. Practical value: Patient care in the time of COVID-19 increasingly requires social distancing which may place additional burden on care partners supporting vulnerable patients. Access to patient notes may promote quality of care by keeping care partners informed, and care partner's input should be used to optimize portal design and electronic access to patient information. (c) 2021 Published by Elsevier B.V.
C1 [Jackson, Sara L.; Liao, Joshua M.; Payne, Thomas H.; Reisch, Lisa M.; Radick, Andrea C.] Univ Washington, Sch Med, Dept Med, Seattle, WA 98104 USA.
   [Shucard, Hannah] Univ Washington, Sch Med, Dept Biostat, Seattle, WA 98104 USA.
   [Bell, Sigall K.; DesRoches, Catherine M.; Fitzgerald, Patricia; Leveille, Suzanne; Walker, Jan] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA.
   [Fossa, Alan] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.
   [Elmore, Joann G.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA.
RP Jackson, SL (通讯作者)，Univ Washington, Mailbox 359892,325 Ninth Ave, Seattle, WA 98104 USA.
EM sljack@uw.edu
OI DesRoches, Catherine/0000-0001-5373-855X
FU Robert Wood Johnson Foundation; Gordon and Betty Moore Foundation;
   Peterson Center on Healthcare; Cambia Health Foundation
FX This work was generously supported by the Robert Wood Johnson
   Foundation, the Gordon and Betty Moore Foundation, the Peterson Center
   on Healthcare, and the Cambia Health Foundation.
CR AARP Public Policy Institute, 2020, NAT ALL CAR CAR US
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NR 20
TC 1
Z9 1
U1 1
U2 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0738-3991
EI 1873-5134
J9 PATIENT EDUC COUNS
JI Patient Educ. Couns.
PD FEB
PY 2022
VL 105
IS 2
BP 290
EP 296
DI 10.1016/j.pec.2021.08.025
PG 7
WC Public, Environmental & Occupational Health; Social Sciences,
   Interdisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Social Sciences - Other
   Topics
GA YT6KV
UT WOS:000751467200006
PM 34481675
OA hybrid
DA 2022-07-18
ER

PT J
AU Giles, B
   Meredith, P
   Robson, S
   Smith, G
   Chauhan, A
AF Giles, Benjamin
   Meredith, Paul
   Robson, Samuel
   Smith, Gary
   Chauhan, Anoop
CA PACIFIC-19 COG-UK Res Grps
TI The SARS-CoV-2 B.1.1.7 variant and increased clinical severity-the jury
   is out
SO LANCET INFECTIOUS DISEASES
LA English
DT Letter
AB 384: 2092-101. 2 Scully M, Singh D, Lown R, et al. Pathologic antibodies to platelet factor 4 after ChAdOx1 nCoV-19 vaccination. N Engl J Med 2021; 384: 2202-11. 3 MacNeil JR, Su JR, Broder KR, et al. Updated recommendations from the Advisory Committee on Immunization Practices for use of the Janssen (Johnson & Johnson) COVID-19 vaccine after reports of thrombosis with thrombocytopenia syndrome among vaccine recipients-United States, April 2021. MMWR Morb Mortal Wkly Rep 2021; 70: 651-56. 4 Borobia AM, Carcas AJ, Perez-Olmeda M, et al. Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-S-primed participants (CombiVacS): a multicentre, open-label, randomised, controlled, phase 2 trial. Lancet 2021; 398: 121-30. 5 Khoury DS, Cromer D, Reynaldi A, et al. Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection. Nat Med 2021; published online May 17. https://doi.org/10.1038/s41591-02101377-8.
C1 [Giles, Benjamin; Meredith, Paul; Chauhan, Anoop] Portsmouth Hosp Univ NHS Trust, Queen Alexandra Hosp, Res & Innovat Dept, Portsmouth PO6 3LY, Hants, England.
   [Robson, Samuel] Univ Portsmouth, Ctr Enzyme Innovat, Portsmouth, Hants, England.
   [Smith, Gary] Bournemouth Univ, Fac Hlth & Social Sci, Ctr Postgrad Med Res & Educ, Bournemouth, Dorset, England.
RP Giles, B (通讯作者)，Portsmouth Hosp Univ NHS Trust, Queen Alexandra Hosp, Res & Innovat Dept, Portsmouth PO6 3LY, Hants, England.
EM benjamin.giles@doctors.org.uk
OI Meredith, Paul/0000-0002-5464-371X
CR Challen R, 2021, BMJ-BRIT MED J, V372, DOI 10.1136/bmj.n579
   Davies NG, 2021, NATURE, V593, P270, DOI [10.1038/s41586-021-03426-1, 10.1101/2021.02.01.21250959]
   Frampton D, 2021, LANCET INFECT DIS, V21, P1246, DOI 10.1016/S1473-3099(21)00170-5
NR 3
TC 10
Z9 10
U1 0
U2 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1473-3099
EI 1474-4457
J9 LANCET INFECT DIS
JI Lancet Infect. Dis.
PD SEP
PY 2021
VL 21
IS 9
BP 1213
EP 1214
DI 10.1016/S1473-3099(21)00356-X
EA AUG 2021
PG 2
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA UI2OL
UT WOS:000690453300020
PM 34197767
OA Green Published
DA 2022-07-18
ER

PT J
AU Dalmartello, M
   La Vecchia, C
   Bertuccio, P
   Boffetta, P
   Levi, F
   Negri, E
   Malvezzi, M
AF Dalmartello, M.
   La Vecchia, C.
   Bertuccio, P.
   Boffetta, P.
   Levi, F.
   Negri, E.
   Malvezzi, M.
TI European cancer mortality predictions for the year 2022 with focus on
   ovarian cancer
SO ANNALS OF ONCOLOGY
LA English
DT Article
DE cancer; Europe; mortality rates; prediction models; ovarian cancer;
   COVID-19
ID COLORECTAL-CANCER; GASTRIC-CANCER; RISK-FACTORS; DIAGNOSIS; COUNTRIES;
   SURVIVAL; THERAPY; TRENDS; ADULTS; WOMEN
AB Background: Cancer mortality rates, though not absolute numbers of deaths, have been decreasing over the last three decades in Europe.
   Materials and methods: We estimated projections and the number of avoided deaths for total cancer mortality and 10 major cancer sites, between 1989 and 2022, for the European Union (EU), the UK, France, Germany, Italy, Poland and Spain using cancer death certification and population data since 1970 from the World Health Organization and Eurostat.
   Results: In the EU, we predict 1 269 200 cancer deaths in 2022; corresponding age-standardized rates (world) fall 6% to 126.9 deaths/100 000 in men and 4% to 80.2/100 000 women since 2017. Male lung cancer is expected to fall 10% reaching 30.9/100 000. The rise in female lung cancer mortality slowed (+2% to 13.8/100 000). We estimated 369 000 (23%) avoided deaths in 2022 alone and a total of 5 394 000 (12%) deaths since the peak rate in 1988. Stomach, colorectal, breast and prostate cancers showed substantial declines, between 5% and 16% over the past 5 years. Pancreatic cancer remained stable in men (8.1/100 000) and rose 3% in women (5.9/100 000), becoming the third cause of cancer mortality in the EU (87 300 deaths), overtaking breast cancer (86 300 deaths). The fall in uterine cancers slowed down (-4%) to 4.7/100 000. Bladder cancer fell 9% in men, but was stable in women. Leukaemias fell more than 10%. Ovarian cancer mortality declined over the past decade in all considered countries. EU predicted rates were 4.3/100 000 (-13%) all ages, 1.2/100 000 (-26%) at 20-49, 15.3/100 000 (-11%) at 50-69 and 32.3/100 000 (-11%) at 70-79 years.
   Conclusions: We predicted additional declines in cancer mortality rates for 2022. The slowdown in female lung cancer mortality reflects some levelling of smoking in women. Favourable ovarian cancer trends are likely to continue and are largely attributable to the spreading oral contraceptive use and some impact of improved diagnosis and management.
C1 [Dalmartello, M.; La Vecchia, C.; Bertuccio, P.; Negri, E.; Malvezzi, M.] Univ Milan, Dept Clin Sci & Community Hlth, Via Vanzetti 5, I-20122 Milan, Italy.
   [Boffetta, P.] SUNY Stony Brook, Stony Brook Canc Ctr, Stony Brook, NY 11794 USA.
   [Boffetta, P.; Negri, E.] Univ Bologna, Dept Med & Surg Sci, Bologna, Italy.
   [Levi, F.] Univ Lausanne, Ctr Primary Care & Publ Hlth Unisante, Dept Epidemiol & Hlth Serv Res, Lausanne, Switzerland.
   [Negri, E.] Pegaso Online Univ, Dept Humanities, Naples, Italy.
RP La Vecchia, C (通讯作者)，Univ Milan, Dept Clin Sci & Community Hlth, Via Vanzetti 5, I-20122 Milan, Italy.
EM carlo.lavecchia@unimi.it
FU Italian Association for Cancer Research (AIRC) [22987]; Ministero
   dell'Istruzione, dell'Universita e della Ricerca (MIUR) [RBSI1465UH]
FX This work was supported by the Italian Association for Cancer Research
   (AIRC) [grant number 22987] ; Ministero dell'Istruzione, dell'Universita
   e della Ricerca (MIUR) , with aScientific Independence of Young
   Researchers (SIR) 2014 grant [grant number RBSI1465UH] .
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NR 65
TC 2
Z9 2
U1 16
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0923-7534
EI 1569-8041
J9 ANN ONCOL
JI Ann. Oncol.
PD MAR
PY 2022
VL 33
IS 3
BP 330
EP 339
DI 10.1016/j.annonc.2021.12.007
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA YZ7NR
UT WOS:000755659500012
PM 35090748
DA 2022-07-18
ER

PT J
AU Wiberg, S
   Whitling, S
   Bergstrom, L
AF Wiberg, Sara
   Whitling, Susanna
   Bergstrom, Liza
TI Tracheostomy management by speech-language pathologists in Sweden
SO LOGOPEDICS PHONIATRICS VOCOLOGY
LA English
DT Article; Early Access
DE Speech-language therapy; speaking valve; questionnaire; tracheotomy;
   practice; critical care; tracheostomy team
AB Purpose: Speech-language pathologists' (SLPs) role in tracheostomy management is well described internationally. Surveys from Australia and the United Kingdom show high clinical consistency in SLP tracheostomy management, and that practice follows guidelines, research evidence and protocols. Swedish SLPs work with tracheostomised patients, however, the content and extent of this practice, and how it compares to international research is unknown. This study reports how SLPs in Sweden work with tracheostomised patients, investigating (a) the differences and similarities in SLPs tracheostomy management and (b) the facilitators and barriers to tracheostomy management, as reported by SLPs.
   Methods: A study-specific, online questionnaire was completed by 28 SLPs who had managed tracheostomised patients during the previous year. This study was conducted in 2018, pre Covid-19 pandemic. The answers were analysed for exploratory descriptive comparison of data. Content analyses were made on answers from open-ended questions.
   Results: Swedish SLPs manage tracheostomised patients, both for dysphagia and communication. During this study, the use of protocols and guidelines were limited and SLPs were often not part of a tracheostomy team. Speech-language pathologists reported that the biggest challenges in tracheostomy management were in (a) collaboration with other professionals, (b) unclear roles and (c) self-perceived inexperience. Improved collaboration with other professionals and clearer roles was suggested to facilitate team tracheostomy management.
   Conclusions: This study provides insight into SLP tracheostomy management in Sweden, previously uncharted. Results suggest improved collaboration, further education and clinical training as beneficial for a clearer and more involved SLP role in tracheostomy management.
C1 [Wiberg, Sara] Helsingborg Hosp, Dept Speech & Language Therapy, Charlotte Yhlens Gata 5, S-25187 Helsingborg, Sweden.
   [Wiberg, Sara; Whitling, Susanna] Lund Univ, Fac Med, Dept Logoped Phoniatr & Audiol, Lund, Sweden.
   [Bergstrom, Liza] Univ Gothenburg, Inst Neurosci & Physiol, Dept Clin Neurosci & Rehabil, Div Speech & Language Pathol, Gothenburg, Sweden.
   [Bergstrom, Liza] REMEO Stockholm, Skondal, Sweden.
RP Wiberg, S (通讯作者)，Helsingborg Hosp, Dept Speech & Language Therapy, Charlotte Yhlens Gata 5, S-25187 Helsingborg, Sweden.
EM sara.wiberg@med.lu.se
OI Bergstrom, Liza/0000-0002-6749-9390; Wiberg, Sara/0000-0001-6161-8443
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   Sutt AL, 2015, J CRIT CARE, V30, P491, DOI 10.1016/j.jcrc.2014.12.017
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   Ward E, 2008, AM J SPEECH-LANG PAT, V17, P265, DOI 10.1044/1058-0360(2008/024)
   Ward E, 2007, J MED SPEECH-LANG PA, V15, P7
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NR 42
TC 0
Z9 1
U1 2
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1401-5439
EI 1651-2022
J9 LOGOP PHONIATR VOCO
JI Logop. Phoniatr. Vocology.
DI 10.1080/14015439.2020.1847320
EA NOV 2020
PG 11
WC Audiology & Speech-Language Pathology; Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Audiology & Speech-Language Pathology; Otorhinolaryngology
GA PM5LC
UT WOS:000603839400001
PM 33356717
OA hybrid
DA 2022-07-18
ER

PT J
AU Ingram, C
   Langhans, T
   Perrotta, C
AF Ingram, Carolyn
   Langhans, Tessa
   Perrotta, Carla
TI Teaching design thinking as a tool to address complex public health
   challenges in public health students: a case study
SO BMC MEDICAL EDUCATION
LA English
DT Article
DE Design thinking; Human-centred design; Public health; Learning outcomes
ID CREATIVITY; INNOVATION
AB Background Developing a public health workforce that can understand problems from a population perspective is essential in the design of impactful user-centred responses to current population health challenges. Design Thinking, a user-driven process for problem-defining and solution-finding, not only has utility in the field of public health but stands as a potential mechanism for developing critical skills -such as empathy, creativity and innovation- amongst future professionals. Though the literature reflects the use of DT across many health sciences disciplines, less research has been published on how students apply learned concepts using real-world challenges of their choice and what difficulties they face during the process. Methods This case study evaluates achieved learning outcomes after the introduction of a design thinking block into post-graduate public health curriculum at the University College Dublin. Two independent assessors evaluated student learning outcomes and observed difficulties during the process by assessing group presentations to identify and understand any learning difficulties using an ad-hoc designed tool. The tool consisted of twelve items scored using a 5-point Likert scale. Student feedback, in the form of an online survey, was also analysed to determine their level of enjoyment, perceived learning outcomes and opinions on the course content. Results The assessors evaluated thirteen DT group presentations and reports from 50 students. The groups chose a range of topics from socialization of college students during Covid-19 to mental health challenges in a low-income country. Independent assessment of assignments revealed that the highest scores were reached by groups who explored a challenge relevant to their own lives (more than 80% of total possible points versus 60% class average). The groups that explored challenges more distant to themselves struggled with problem finding with a mean score of 2.05 (SD +/- 1.2) out of 5 in that domain. The greatest difficulties were observed in problem finding and ideation. Though most students found the design thinking block enjoyable and relevant to their education, they recommended that the DT block be a stand-alone module. Students recognized that groups who chose a familiar topic experienced fewer difficulties throughout the process. Conclusion The study showed that DT learning outcomes were best achieved when students focused on challenges, they had either personally experienced or were familiar with. These findings provide insight for future iterations of DT workshops and support the teaching of user-centred approaches to future public health practitioners.
C1 [Ingram, Carolyn; Langhans, Tessa; Perrotta, Carla] Univ Coll Dublin, Dublin, Ireland.
RP Perrotta, C (通讯作者)，Univ Coll Dublin, Dublin, Ireland.
EM carla.perrotta@ucd.ie
OI Ingram, Carolyn/0000-0002-3789-1463; Perrotta, Carla/0000-0001-5986-4581
FU Government of Irelands' Human Capital Initiative
FX Dr Carla Perrotta is a UCD Innovation Academy Fellow. The UCD Innovation
   Fellowship is supported by the Government of Irelands' Human Capital
   Initiative (2020-2025).
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NR 28
TC 0
Z9 0
U1 5
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6920
J9 BMC MED EDUC
JI BMC Med. Educ.
PD APR 12
PY 2022
VL 22
IS 1
AR 270
DI 10.1186/s12909-022-03334-6
PG 9
WC Education & Educational Research; Education, Scientific Disciplines
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Education & Educational Research
GA 0M1IK
UT WOS:000781915700001
PM 35413916
OA gold, Green Published
DA 2022-07-18
ER

PT J
AU Ernstzen, D
   Keet, J
   Louw, KA
   Park-Ross, J
   Pask, L
   Reardon, C
   Zway, M
   Parker, R
AF Ernstzen, Dawn
   Keet, Janet
   Louw, Kerry-Ann
   Park-Ross, Jocelyn
   Pask, Lorien
   Reardon, Cameron
   Zway, Maia
   Parker, Romy
TI "So, you must understand that that group changed everything":
   perspectives on a telehealth group intervention for individuals with
   chronic pain
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
DE Telehealth; Chronic pain; Patient experience; Chronic pain management
   programmes; Qualitative
ID MANAGEMENT; CARE
AB Background The Patient Education Empowerment Programme (PEEP) is an interdisciplinary group intervention for people living with chronic pain. As a result of the COVID-19 pandemic, lockdown and restrictions on in-person group-based health care delivery in South Africa, PEEP was modified to a telehealth electronic format (ePEEP) and offered to patients on a waiting list at two interdisciplinary chronic pain clinics in Cape Town, South Africa. The purpose of this study was to explore the feasibility and acceptability of ePEEP through the perspectives of individuals with chronic pain who participated in ePEEP. Methods A qualitative, exploratory descriptive study was conducted. One month after completion of the 6-week ePEEP programme, individuals who participated, were recruited for the study. Data were collected through semi-structured interviews. Data analysis followed an iterative process of inductive content analysis. Results Six individuals, all women, consented and participated in the study. Three main themes emerged from the data. Theme one focussed on how ePEEP initiated a journey of personal development and discovery within the participants. In theme two, participants reflected on the importance and value of building peer and therapeutic relationships as part of ePEEP. In theme 3, participants shared that the online learning environment had features which influenced learning about pain in different ways. Conclusion ePEEP was found to be acceptable, feasible and valuable for the participants. ePEEP facilitated self-discovery, empowerment, relationship building and transformation in the participants, through experiential learning. Although barriers and facilitators to learning were present, both enhanced the learning experience. The positive reception of this telehealth initiative indicates potential for enhanced access to chronic pain management services in the South African setting.
C1 [Ernstzen, Dawn] Stellenbosch Univ, Div Physiotherapy, Dept Hlth & Rehabil Sci, Cape Town, South Africa.
   [Keet, Janet; Park-Ross, Jocelyn; Pask, Lorien; Parker, Romy] Univ Cape Town, Pain Management Unit, Dept Anaesthesia & Perioperat Med, Cape Town, South Africa.
   [Louw, Kerry-Ann] Stellenbosch Univ, Dept Psychiat, Stellenbosch, South Africa.
   [Reardon, Cameron] Stellenbosch Univ, Ukwanda Ctr Rural Hlth, Div Physiotherapy, Stellenbosch, South Africa.
   [Zway, Maia] Stellenbosch Univ, Dept Anaesthesiol & Crit Care, Tygerberg Hosp, Stellenbosch, South Africa.
RP Parker, R (通讯作者)，Univ Cape Town, Pain Management Unit, Dept Anaesthesia & Perioperat Med, Cape Town, South Africa.
EM romy.parker@uct.ac.za
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NR 28
TC 0
Z9 0
U1 3
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD JUN 4
PY 2022
VL 23
IS 1
AR 538
DI 10.1186/s12891-022-05467-7
PG 16
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA 1V2MC
UT WOS:000805929300007
PM 35658929
OA gold, Green Published
DA 2022-07-18
ER

PT J
AU Brennan, L
   Sadeghi, F
   O'Neill, L
   Guinan, E
   Smyth, L
   Sheill, G
   Smyth, E
   Doyle, SL
   Timon, CM
   Connolly, D
   O'Sullivan, J
   Reynolds, JV
   Hussey, J
AF Brennan, Louise
   Sadeghi, Fatemeh
   O'Neill, Linda
   Guinan, Emer
   Smyth, Laura
   Sheill, Grainne
   Smyth, Emily
   Doyle, Suzanne L.
   Timon, Claire M.
   Connolly, Deirdre
   O'Sullivan, Jacintha
   Reynolds, John, V
   Hussey, Juliette
TI Telehealth Delivery of a Multi-Disciplinary Rehabilitation Programme for
   Upper Gastro-Intestinal Cancer: ReStOre@Home Feasibility Study
SO CANCERS
LA English
DT Article
DE survivorship; rehabilitation; exercise; nutrition; telehealth;
   feasibility; upper gastro-intestinal cancer
ID QUALITY-OF-LIFE; ESOPHAGEAL CANCER; EXERCISE INTERVENTION; SURVIVORS;
   RECRUITMENT; FATIGUE; IMPACT; CARE; EXPERIENCES; MANAGEMENT
AB Simple Summary Throughout the COVID-19 pandemic, many cancer care services have safely been delivered via telehealth. Multi-disciplinary rehabilitation programmes can help address the complex physical, nutritional and quality of life needs of upper gastrointestinal (UGI) cancer survivors, but it is unknown how well these multi-component programmes translate to a telehealth model of delivery. Therefore, we assessed the feasibility of running a 12-week exercise and nutrition rehabilitation programme for UGI cancer via telehealth. Participants found the telehealth model safe, convenient and highly satisfactory. Lower levels of technology skills were a barrier to recruitment, and some participants needed help with using the technology. Some adaptations to how the exercise programme was delivered were required. Participants recommended that future versions of the programme would have some element of in-person contact. Cancer survivors should receive all possible supports to enable their participation in telehealth programmes. Background: Telehealth has enabled access to rehabilitation throughout the pandemic. We assessed the feasibility of delivering a multi-disciplinary, multi-component rehabilitation programme (ReStOre@Home) to cancer survivors via telehealth. Methods: This single-arm mixed methods feasibility study recruited participants who had completed curative treatment for oesophago-gastric cancer for a 12-week telehealth rehabilitation programme, involving group resistance training, remotely monitored aerobic training, one-to-one dietetic counselling, one-to-one support calls and group education. The primary outcome was feasibility, measured by recruitment rates, attendance, retention, incidents, acceptability, Telehealth Usability Questionnaire (TUQ) and analysis of semi-structured interviews. Results: Characteristics of the twelve participants were: 65.42 +/- 7.24 years; 11 male; 10.8 +/- 3.9 months post-op; BMI 25.61 +/- 4.37; received neoadjuvant chemotherapy 7/12; received adjuvant chemotherapy 4/12; hospital length of stay 16 days (median). Recruitment rate was 32.4%, and retention rate was 75%. Mean attendance was: education 90%; dietetics 90%; support calls 84%; resistance training 78%. Mean TUQ score was 4.69/5. Adaptations to the planned resistance training programme were required. Participants reported that ReStOre@Home enhanced physical and psychological wellbeing, and online delivery was convenient. Some reported a preference for in-person contact but felt that the online group sessions provided adequate peer support. Conclusion: Telehealth delivery of ReStOre@Home was most feasible in individuals with moderate to high levels of digital skills. Low level of digitals skills was a barrier to recruitment and retention. Participants reported high levels of programme adherence and participant satisfaction. Adaptations to future programmes, including introducing elements of in-person contact, are required.
C1 [Brennan, Louise; Sadeghi, Fatemeh; O'Neill, Linda; Smyth, Laura; Smyth, Emily; Hussey, Juliette] Trinity Coll Dublin, Sch Med, Discipline Physiotherapy, Dublin D08 W9RT, Ireland.
   [Brennan, Louise; Sadeghi, Fatemeh; O'Neill, Linda; Guinan, Emer; Smyth, Laura; Sheill, Grainne; Smyth, Emily; Connolly, Deirdre; O'Sullivan, Jacintha; Reynolds, John, V; Hussey, Juliette] Trinity St Jamess Canc Inst, Dublin D08 NHY1, Ireland.
   [Guinan, Emer] Trinity Coll Dublin, Sch Med, Dublin D08 W9RT, Ireland.
   [Sheill, Grainne] St James Hosp, Physiotherapy Dept, Dublin D08 NHY1, Ireland.
   [Doyle, Suzanne L.] Technol Univ Dublin, Sch Biol & Hlth Sci, Dublin D07 ADY7, Ireland.
   [Timon, Claire M.] Dublin City Univ, Ctr eIntegrated Care, Sch Nursing Psychotherapy & Community Hlth, Dublin D09 X984, Ireland.
   [Connolly, Deirdre] Trinity Coll Dublin, Discipline Occupat Therapy, Dublin D08 W9RT, Ireland.
   [O'Sullivan, Jacintha; Reynolds, John, V] Trinity Coll Dublin, Trinity Translat Med Inst, Dept Surg, St Jamess Hosp Dublin, Dublin D08 W9RT, Ireland.
RP Brennan, L (通讯作者)，Trinity Coll Dublin, Sch Med, Discipline Physiotherapy, Dublin D08 W9RT, Ireland.; Brennan, L (通讯作者)，Trinity St Jamess Canc Inst, Dublin D08 NHY1, Ireland.
EM brennl10@tcd.ie; sadeghif@tcd.ie; loneil4@tcd.ie; guinane1@tcd.ie;
   laurahsmyth@gmail.com; sheillg@tcd.ie; emythe3@tcd.ie;
   suzanne.doyle@tudublin.ie; claire.timon@dcu.ie; connoldm@tcd.ie;
   osullij4@tcd.ie; reynoldsjv@stjames.ie; jmhussey@tcd.ie
OI O'Neill, Linda/0000-0002-0109-9650
FU Health Research Board (HRB) Ireland Definitive Intervention and
   Feasibility Award [DIFA-2018-009]
FX This research was funded by the Health Research Board (HRB) Ireland
   Definitive Intervention and Feasibility Award (DIFA-2018-009). The HRB
   have no direct role in the design, conduct, or analysis of this trial.
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NR 81
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD JUN
PY 2022
VL 14
IS 11
AR 2707
DI 10.3390/cancers14112707
PG 19
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 1Z4AR
UT WOS:000808770000001
PM 35681687
OA gold, Green Published
DA 2022-07-18
ER

PT J
AU Xie, TA
   He, ZJ
   Liang, C
   Dong, HN
   Zhou, J
   Fan, SJ
   Guo, XG
AF Xie, Tian-Ao
   He, Zhi-Jian
   Liang, Chuan
   Dong, Hao-Neng
   Zhou, Jie
   Fan, Shu-Jin
   Guo, Xu-Guang
TI An integrative bioinformatics analysis for identifying hub genes
   associated with infection of lung samples in patients infected with
   SARS-CoV-2
SO EUROPEAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Article
DE SARS-CoV-2; Hub genes; Protein-protein interactions network;
   Differentially expressed genes
ID CYTOKINE STORM; SPIKE PROTEIN; CORONAVIRUS; CHEMOKINES; RECEPTORS;
   ACTIVATION; PNEUMONIA; EVOLUTION; AUTOPHAGY; OUTBREAK
AB Background At the end of 2019, the world witnessed the emergence and ravages of a viral infection induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Also known as the coronavirus disease 2019 (COVID-19), it has been identified as a public health emergency of international concern (PHEIC) by the World Health Organization (WHO) because of its severity. Methods The gene data of 51 samples were extracted from the GSE150316 and GSE147507 data set and then processed by means of the programming language R, through which the differentially expressed genes (DEGs) that meet the standards were screened. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed on the selected DEGs to understand the functions and approaches of DEGs. The online tool STRING was employed to construct a protein-protein interaction (PPI) network of DEGs and, in turn, to identify hub genes. Results A total of 52 intersection genes were obtained through DEG identification. Through the GO analysis, we realized that the biological processes (BPs) that have the deepest impact on the human body after SARS-CoV-2 infection are various immune responses. By using STRING to construct a PPI network, 10 hub genes were identified, including IFIH1, DDX58, ISG15, EGR1, OASL, SAMD9, SAMD9L, XAF1, IFITM1, and TNFSF10. Conclusion The results of this study will hopefully provide guidance for future studies on the pathophysiological mechanism of SARS-CoV-2 infection.
C1 [Xie, Tian-Ao; He, Zhi-Jian; Liang, Chuan; Dong, Hao-Neng; Zhou, Jie; Fan, Shu-Jin; Guo, Xu-Guang] Guangzhou Med Univ, Dept Clin Lab Med, Affiliated Hosp 3, Guangzhou 510150, Peoples R China.
   [Xie, Tian-Ao; He, Zhi-Jian; Liang, Chuan; Dong, Hao-Neng; Zhou, Jie; Fan, Shu-Jin; Guo, Xu-Guang] Guangzhou Med Univ, Dept Clin Med, Clin Sch 3, Guangzhou 511436, Peoples R China.
   [Guo, Xu-Guang] Guangzhou Med Univ, Key Lab Major Obstet Dis Guangdong Prov, Affiliated Hosp 3, Guangzhou 510150, Peoples R China.
   [Guo, Xu-Guang] Guangzhou Med Univ, Key Lab Reprod & Genet, Affiliated Hosp 3, Guangdong Higher Educ Inst, Guangzhou 510150, Peoples R China.
RP Guo, XG (通讯作者)，Guangzhou Med Univ, Dept Clin Lab Med, Affiliated Hosp 3, Guangzhou 510150, Peoples R China.; Guo, XG (通讯作者)，Guangzhou Med Univ, Dept Clin Med, Clin Sch 3, Guangzhou 511436, Peoples R China.; Guo, XG (通讯作者)，Guangzhou Med Univ, Key Lab Major Obstet Dis Guangdong Prov, Affiliated Hosp 3, Guangzhou 510150, Peoples R China.; Guo, XG (通讯作者)，Guangzhou Med Univ, Key Lab Reprod & Genet, Affiliated Hosp 3, Guangdong Higher Educ Inst, Guangzhou 510150, Peoples R China.
EM gysygxg@gmail.com
OI Guo, Xu-guang/0000-0003-1302-5234
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NR 52
TC 1
Z9 1
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0949-2321
EI 2047-783X
J9 EUR J MED RES
JI Eur. J. Med. Res.
PD DEC 17
PY 2021
VL 26
IS 1
AR 146
DI 10.1186/s40001-021-00609-4
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA XQ0UJ
UT WOS:000731270000002
PM 34920753
OA Green Published, gold
DA 2022-07-18
ER

PT J
AU Wilf-Miron, R
   Avni, S
   Valinsky, L
   Myers, V
   Ziv, A
   Peretz, G
   Luxenburg, O
   Saban, M
   Feder-Bubis, P
AF Wilf-Miron, Rachel
   Avni, Shlomit
   Valinsky, Liora
   Myers, Vicki
   Ziv, Arnona
   Peretz, Gidi
   Luxenburg, Osnat
   Saban, Mor
   Feder-Bubis, Paula
TI Developing a National Set of Health Equity Indicators Using a Consensus
   Building Process
SO INTERNATIONAL JOURNAL OF HEALTH POLICY AND MANAGEMENT
LA English
DT Article; Early Access
DE Consensus Building; Delphi Technique; Health Equity; National Equity
   Indicators; Health Disparities
ID SOCIAL DETERMINANTS; DELPHI; INEQUALITIES; DISPARITIES; METHODOLOGY;
   SURVIVAL; COVID-19; LESSONS; SYSTEM
AB Background: Considerable health inequities documented in Israel between communities, populations and regions, undermine the rights of all citizens to optimal health. The first step towards health equity is agreement on a set of national indicators, reflecting equity in healthcare provision and health outcomes, and allowing monitoring of the impact of interventions on the reduction of disparities. We describe the process of reaching a consensus on a defined set of national equity indicators. Methods: The study was conducted between January 2019 and June 2020, in a multistage design: (A) Identifying appropriate and available inequity measures via interviews with stakeholders. (B) Agreement on the screening criteria (public health importance; gap characteristics; potential for change; public interest) and relative weighting. (C) Constructing the consultation framework as an online, 3-round Delphi technique, with a range of experts recruited from the health, welfare and education sectors. Results: Participants were of diverse age, gender, geographic location, religion and ethnicity, and came from academia, healthcare provision, government ministries and patient representative groups. Thirty measures of inequity, presented to participants, represented the following domains: Health promotion (11 indicators), acute and chronic morbidity (11), life expectancy and mortality (2), health infrastructures and affordability of care (4), education and employment (2). Of the 77 individuals contacted, 75 (97%) expressed willingness to participate, and 55 (73%) completed all three scoring rounds. The leading ten indicators were: Diabetes care, childhood obesity, adult obesity, distribution of healthcare personnel, fatal childhood injuries, cigarette smoking, infant mortality, ability to afford care, access to psychotherapy and distribution of hospital beds. Agreement among raters, measured as intra-class correlation coefficient (ICC), was 0.75. Conclusion: A diverse range of consultants reached a consensus on the most important national equity indicators, including both clinical and system indicators. Results should be used to guide governmental decision-making and inter-sectoral strategies, furthering the pursuit of a more equitable healthcare system. Keywords: Consensus Building, Delphi Technique, Health Equity, National Equity Indicators, Health Disparities Copyright: (c) 2021 The Author(s); Published by Kerman University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Citation: Wilf-Miron R, Avni S, Valinsky L, et al. Developing a national set of health equity indicators using a consensus building process. Int J Health Policy Manag. 2021;x(x):x-x. doi:10.34172/ijhpm.2021.54
C1 [Wilf-Miron, Rachel; Myers, Vicki; Ziv, Arnona; Saban, Mor] Sheba Med Ctr, Gertner Inst Epidemiol & Hlth Policy Res, Ramat Gan, Israel.
   [Wilf-Miron, Rachel] Tel Aviv Univ, Sch Publ Hlth, Sackler Fac Med, Tel Aviv, Israel.
   [Avni, Shlomit; Peretz, Gidi] Minist Hlth, Strateg & Econ Planning Adm, Jerusalem, Israel.
   [Valinsky, Liora] Minist Hlth, Publ Hlth Serv, Jerusalem, Israel.
   [Luxenburg, Osnat] Minist Hlth, Med Technol Hlth Informat & Res Directorate, Jerusalem, Israel.
   [Feder-Bubis, Paula] Ben Gurion Univ Negev, Fac Hlth Sci, Dept Hlth Policy & Management, Beer Sheva, Israel.
   [Feder-Bubis, Paula] Ben Gurion Univ Negev, Guildford Glazer Fac Business & management, Beer Sheva, Israel.
RP Saban, M (通讯作者)，Sheba Med Ctr, Gertner Inst Epidemiol & Hlth Policy Res, Ramat Gan, Israel.
EM morsab1608@gmail.com
RI Saban, Mor/ABE-8773-2021
OI Saban, Mor/0000-0001-6869-0907; Myers, Vicki/0000-0001-5866-3948;
   Valinsky, Liora/0000-0003-0285-6681
FU Israel National Institute for Health Policy Research [0601445671]
FX The research was funded by a grant from The Israel National Institute
   for Health Policy Research (Grant number 0601445671).
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NR 61
TC 0
Z9 0
U1 3
U2 6
PU KERMAN UNIV MEDICAL SCIENCES
PI KERMAN
PA JAHAD BLVD, KERMAN, 7619813159, IRAN
EI 2322-5939
J9 INT J HEALTH POLICY
JI Int. J. Health Policy Manag.
DI 10.34172/ijhpm.2021.54
EA JUN 2021
PG 11
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA WZ4RI
UT WOS:000719955900001
PM 34273926
OA gold, Green Submitted
DA 2022-07-18
ER

PT J
AU Sohrab, SS
   El-Kafrawy, SA
   Azhar, EI
AF Sohrab, Sayed Sartaj
   El-Kafrawy, Sherif Aly
   Azhar, Esam Ibraheem
TI Effect of insilico predicted and designed potential siRNAs on inhibition
   of SARS-CoV-2 in HEK-293 cells
SO JOURNAL OF KING SAUD UNIVERSITY SCIENCE
LA English
DT Article
DE In silico prediction; Designing; siRNAs; SARS-CoV-2; HEK-293 cells
AB Objectives: The COVID-19 was identified for the first time from the sea food market, Wuhan city, China in 2019 and the pathogenic organism was identified as SARS-CoV-2. Currently, this virus has spread to 223 countries and territories and known as a serious issue for the global human community. Many vaccines have been developed and used for immunization.Methods: We have reported the insilico prediction, designing, secondary structure prediction, molecular docking analysis, and in vitro assessment of siRNAs against SARS-CoV-2. The online bioinformatic approach was used for siRNAs selection and designing. The selected siRNAs were evaluated for antiviral efficacy by using Lipofectamine 2000 as delivery agent to HEK-293 cells. The MTT assay was used for cytotoxicity determination. The antiviral efficacy of potential siRNAs was determined based on the Ct value of q-RT-PCR and the data analysis was done by Prism-GraphPad software.Results: The analyzed data resulted in the selection of only three siRNAs out of twenty-six siRNAs gener-ated by online software. The secondary structure prediction and molecular docking analysis of siRNAs revealed the efficient binding to the target. There was no cellular toxicity observed in the HEK-293 cells at any tested concentrations of siRNAs. The purification of RNA was completed from inoculated cells and subjected to q-RT-PCR. The highest Ct value was observed in siRNA 3 than the others. The results offered valuable evidence and invigorated us to assess the potency of siRNAs by using alone or in combination in other human cells. Conclusion: The data generated from this study indicates the significance of in silico prediction and nar-row down the potential siRNA' against SARS-CoV-2, and molecular docking investigation offered the effective siRNAs binding with the target. Finally, it is concluded that the online bioinformatics approach provided the prediction and selection of siRNAs with better antiviral efficacy. The siRNA-3 was observed to be the best for reduction of viral RNA in cells.(c) 2022 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Sohrab, Sayed Sartaj; El-Kafrawy, Sherif Aly; Azhar, Esam Ibraheem] King Abdulaziz Univ, King Fahd Med Res Ctr, Special Infect Agents Unit, Post Box 80216, Jeddah 21589, Saudi Arabia.
   [Sohrab, Sayed Sartaj; El-Kafrawy, Sherif Aly; Azhar, Esam Ibraheem] King Abdulaziz Univ, Fac Appl Med Sci, Dept Med Lab Sci, Jeddah, Saudi Arabia.
RP Sohrab, SS (通讯作者)，King Abdulaziz Univ, King Fand Med Res Ctr, Jeddah 21589, Saudi Arabia.
EM ssohrab@kau.edu.sa
FU Ministry of Education in Saudi Arabia [IFPRC-204-141-2020]; King
   Abdulaziz University, DSR, Jeddah, Saudi Arabia
FX & nbsp;The authors extend their appreciation to the Deputyship for
   Research & Innovation, Ministry of Education in Saudi Arabia for funding
   this research work through the project number IFPRC-204-141-2020 and
   King Abdulaziz University, DSR, Jeddah, Saudi Arabia.
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NR 40
TC 0
Z9 0
U1 2
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29a, 1043 NX AMSTERDAM, NETHERLANDS
SN 1018-3647
EI 2213-686X
J9 J KING SAUD UNIV SCI
JI J. King Saud Univ. Sci.
PD JUN
PY 2022
VL 34
IS 4
AR 101965
DI 10.1016/j.jksus.2022.101965
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 1B9RT
UT WOS:000792768300001
PM 35313445
OA Green Published, gold
DA 2022-07-18
ER

PT J
AU Islam, I
   Nelson, A
   Longo, M
   Byrne, A
AF Islam, Ishrat
   Nelson, Annmarie
   Longo, Mirella
   Byrne, Anthony
TI Before the 2020 Pandemic: an observational study exploring public
   knowledge, attitudes, plans, and preferences towards death and end of
   life care in Wales
SO BMC PALLIATIVE CARE
LA English
DT Article
DE End of Life Care; Death and dying; Public attitudes; Public health;
   Supportive care; Terminal care; Cultural issues; Communication; Quality
   of life
AB Background Understanding public attitudes towards death and dying is important to inform public policies around End of Life Care (EoLC). We studied the public attitudes towards death and dying in Wales. Methods An online survey was conducted in 2018. Social media and the HealthWiseWales platform were used to recruit participants. Data were analysed using descriptive statistics and thematic analysis. Results 2,210 people participated. Loss of independence (84%), manner of death, and leaving their beloved behind were the biggest fears around death and dying. In terms of EoLC, participants sought timely access to care (84%) and being surrounded by loved ones (62%). Being at home was less of a priority (24%). Only 50% were familiar with Advance Care Planning (ACP). A lack of standard procedures as well as of support for the execution of plans and the ability to revisit those plans hindered uptake. The taboo around death conversations, the lack of opportunities and skills to initiate discussion, and personal fear and discomfort inhibited talking about death and dying. 72% felt that we do not talk enough about death and dying and advocated normalising talking by demystifying death with a positive approach. Health professionals could initiate and support this conversation, but this depended on communication skills and manageable workload pressure. Participants encouraged a public health approach and endorsed the use of: a) social media and other public platforms, b) formal education, c) formal and legal actions, and d) signposting and access to information. Conclusions People are ready to talk about death and dying and COVID-19 has increased awareness. A combination of top-down and bottom-up initiatives across levels and settings can increase awareness, knowledge, and service-utilisation-drivers to support health professionals and people towards shared decisions which align with people's end of life wishes and preferences.
C1 [Islam, Ishrat; Nelson, Annmarie; Longo, Mirella; Byrne, Anthony] Cardiff Univ, Marie Curie Palliat Care Res Ctr, Sch Med, Cardiff CF14 4YS, Wales.
   [Byrne, Anthony] Velindre NHS Trust, Dept Palliat Med, Cardiff CF15 7QZ, Wales.
RP Nelson, A (通讯作者)，Cardiff Univ, Marie Curie Palliat Care Res Ctr, Sch Med, Cardiff CF14 4YS, Wales.
EM NelsonA9@cardiff.ac.uk
RI ; Nelson, Annmarie/B-4893-2009
OI Islam, Ishrat/0000-0003-1395-8173; Nelson, Annmarie/0000-0002-6075-8425
FU One Wales Palliative Care Program of the National End of Life Board of
   the Welsh Government; Cardiff University; Marie Curie Palliative Care
   Research Centre at Cardiff University; Welsh Government's grant; Marie
   Curie Cancer Care core grant fund [MCCC-FCO-17-C]
FX This study was funded by The One Wales Palliative Care Program of the
   National End of Life Board of the Welsh Government. It was sponsored by
   Cardiff University and coordinated by the Marie Curie core-funded Marie
   Curie Palliative Care Research Centre at Cardiff University. II's post
   was funded by the Welsh Government's grant and AN, AB and ML's posts are
   funded by Marie Curie Cancer Care core grant funding (grant reference
   MCCC-FCO-17-C). The funding bodies were not involved in the design of
   the study, data collection, analysis and interpretation, and in writing
   the manuscript.
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NR 50
TC 2
Z9 2
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-684X
J9 BMC PALLIAT CARE
JI BMC Palliat. Care
PD JUL 20
PY 2021
VL 20
IS 1
AR 116
DI 10.1186/s12904-021-00806-2
PG 12
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA TL5II
UT WOS:000674890500001
PM 34284754
OA Green Accepted, Green Published, gold
DA 2022-07-18
ER

PT J
AU Wang, S
   Zhang, Y
   Guan, YG
   Ding, W
   Meng, Y
   Hu, HT
   Liu, ZH
   Zeng, XW
   Wang, MZ
AF Wang, Shu
   Zhang, Yuan
   Guan, Yuguang
   Ding, Wei
   Meng, Yao
   Hu, Huiting
   Liu, Zhenhua
   Zeng, Xianwei
   Wang, Minzhong
TI A nationwide evaluation of the prevalence of and risk factors associated
   with anxiety, depression and insomnia symptoms during the return-to-work
   period of coronavirus disease 2019 in China
SO SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
LA English
DT Article
DE Anxiety; Depression; Insomnia; Coronavirus disease 2019; Cross-sectional
ID PATIENT HEALTH QUESTIONNAIRE; PSYCHOLOGICAL DISTRESS; COVID-19 EPIDEMIC;
   MAJOR DEPRESSION; SARS EPIDEMIC; PEOPLE; AWARENESS; SEVERITY; OUTBREAK;
   DISORDER
AB Purpose To evaluate the prevalence of and risk factors associated with anxiety, depression, and insomnia symptoms during the return-to-work period of coronavirus disease 2019 in China. Methods The authors conducted a large-scale, nationwide, multicenter, cross-sectional study in China. A population-based quota and snowball sampling were designed to recruit a representative sample. Online questionnaires and telephone reviews were used to collect characteristics and assess psychological and sleep problems. Anxiety, depression, and insomnia symptoms were measured by the generalized anxiety disorder-7, patient health questionnaire-9, and insomnia severity index tools. Results A total of 42,000 participants were recruited from 15 centers, and 36,795 valid questionnaires were received. Generally, 18.3, 14.9, and 17.9% of the participants had anxiety, depression, and insomnia symptoms, respectively, and 2.2-2.7% had severe symptoms. Engaging in outside activity once in >= 30 days (OR = 2.719, OR = 2.074, OR = 2.225) and age 50-64 years (OR = 2.431, OR = 1.936, OR = 2.036) were common risk factors for anxiety, depression and insomnia symptoms. Living in Hubei Province (OR = 1.304, OR = 1.242) was a common risk factor for anxiety and insomnia symptoms. Working as frontline medical staff (OR = 2.150) was another risk factor for anxiety symptoms. The health education rate of the samples reached 98.9%. However, the psychological intervention rate was only 16.2%, and 2.5% received targeted interventions. Conclusions An increasing number of people might have psychological and sleep problems. However, the current psychological interventions are not sufficient. Efforts should be made to strengthen interventions for high-risk populations.
C1 [Wang, Shu; Guan, Yuguang] Capital Med Univ, SanBo Brain Hosp, Dept Neurosurg, Beijing 100093, Peoples R China.
   [Zhang, Yuan] Dalian Med Univ, Dalian 116044, Liaoning, Peoples R China.
   [Zhang, Yuan] Dalian Municipal Women & Childrens Med Ctr, Dept Pediat Hematol Oncol, Dalian 116037, Liaoning, Peoples R China.
   [Guan, Yuguang] Beijing Key Lab Epilepsy, Beijing 100093, Peoples R China.
   [Guan, Yuguang] Beijing Inst Brain Disorders, Ctr Epilepsy, Beijing 100093, Peoples R China.
   [Ding, Wei] Liaocheng Peoples Hosp, Dept Neurol, Liaocheng 252000, Shandong, Peoples R China.
   [Meng, Yao] Shandong First Med Univ, Affiliated Hosp 1, Dept Neurol, Jinan 250014, Shandong, Peoples R China.
   [Hu, Huiting] Heze Mudan Peoples Hosp, Dept Neurol, Heze 274000, Shandong, Peoples R China.
   [Liu, Zhenhua] Shandong First Med Univ, Shandong Prov Hosp, Sleep Med Ctr, Jinan 250021, Shandong, Peoples R China.
   [Zeng, Xianwei] Shandong Univ, Qilu Hosp, Dept Neurosurg, Jinan 250012, Shandong, Peoples R China.
   [Wang, Minzhong] Shandong First Med Univ, Shandong Prov Hosp, Dept Neurol, Jinan 250021, Shandong, Peoples R China.
RP Wang, MZ (通讯作者)，Shandong First Med Univ, Shandong Prov Hosp, Dept Neurol, Jinan 250021, Shandong, Peoples R China.
EM WangShu.cn@Outlook.com; wmzwlq@163.com
RI guan, yuguang/AAO-9253-2021; Wang, Shu/AAM-9779-2020
OI Wang, Shu/0000-0002-5914-0804
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NR 46
TC 6
Z9 6
U1 1
U2 10
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0933-7954
EI 1433-9285
J9 SOC PSYCH PSYCH EPID
JI Soc. Psychiatry Psychiatr. Epidemiol.
PD DEC
PY 2021
VL 56
IS 12
BP 2275
EP 2286
DI 10.1007/s00127-021-02046-4
EA FEB 2021
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA WP4NR
UT WOS:000620403700001
PM 33616693
OA Green Published, Bronze
DA 2022-07-18
ER

PT J
AU Stewart, E
   Tavabie, S
   White, N
   Appleyard, S
   Bass, S
   Gilbert, D
   Herriott, R
   Williams, T
   Wells, G
   Young, K
   Minton, O
AF Stewart, E.
   Tavabie, S.
   White, N.
   Appleyard, S.
   Bass, S.
   Gilbert, D.
   Herriott, R.
   Williams, T.
   Wells, G.
   Young, K.
   Minton, O.
TI A Short Report Examining the Introduction of Routine Use of
   Patient-Reported Outcome Measures in a Mixed Oncology Population
SO CLINICAL ONCOLOGY
LA English
DT Article
DE Palliative care; PROMs; remote monitoring; supportive care
ID QUALITY-OF-LIFE; CLINICAL-TRIALS; CANCER
AB Y Aims: People living with treatable but not curable cancer often experience a range of symptoms related to their cancer and its treatment. During the COVID-19 pandemic, face-to-face consultations were reduced and so remote monitoring of these needs was necessary. University Hospitals Sussex implemented the routine use of electronic remote patient-reported outcome measures (PROMs) in a mixed oncology population, focusing on those with treatable but not curable cancers.
   Materials and methods: Over a 9-month period, patients were invited to register with My Clinical Outcomes (MCO) - a secure online platform for the collection of electronic PROMs. They were prompted by e-mail to complete assessments (EORTC QLQ-C30, EQ-5D-3L and EQ-5D VAS) routinely every 2 weeks. The team monitored patient scores and changes in these prompted clinical interventions.
   Results: In total, 324 patients completed at least one assessment. The median number of assessments completed by each patient was eight. The most represented tumour groups were secondary breast (28%), prostate (25%) and other (32%). Median scores for the assessments did not deteriorate in a clinically or numerically significant way for patients living with non-curable conditions for the majority of patients monitored.
   Conclusion: Routine collection of electronic remote PROMs is an effective and useful strategy to provide real-time clinical feedback to teams. With integration into existing systems, online platforms (such as MCO) could provide efficient and patient-centred information for those providing care for people with cancer. (C) 2021 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
C1 [Stewart, E.; Appleyard, S.; Bass, S.; Gilbert, D.; Herriott, R.; Young, K.; Minton, O.] Univ Hosp Sussex, Sussex Canc Ctr, Brighton, E Sussex, England.
   [Tavabie, S.] Barts Hlth NHS Trust, London, England.
   [White, N.] UCL, Marie Curie Palliat Care Res Dept, Div Psychiat, London, England.
   [Williams, T.] My Clin Outcomes, London, England.
   [Wells, G.] Univ Brighton, Brighton & Sussex Med Sch, Dept Med Educ, Brighton, E Sussex, England.
RP Stewart, E (通讯作者)，Univ Hosp Sussex, Sussex Canc Ctr, Brighton, E Sussex, England.
EM eleanor.stewart7@nhs.net
OI Herriott, Rob/0000-0002-5243-6629; White, Nicola/0000-0002-7438-0072;
   Gilbert, Duncan/0000-0003-1859-7012
FU NHS England/Improvement; Sussex Cancer Fund
FX Funding for this project was through a grant for the development of an
   Enhanced Supportive Care service in Oncology at University Hospitals
   Sussex from NHS England/Improvement and funding of the My Clinical
   Outcomes platform was from the Sussex Cancer Fund.
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NR 22
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0936-6555
EI 1433-2981
J9 CLIN ONCOL-UK
JI Clin. Oncol.
PD APR
PY 2022
VL 34
IS 4
BP 241
EP 246
DI 10.1016/j.clon.2021.11.016
PG 6
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA ZS2OL
UT WOS:000768309600029
PM 34876332
OA Green Submitted
DA 2022-07-18
ER

PT J
AU McNabb, SJN
   Magowe, M
   Shaw, N
   Berrian, AM
   Wilkes, M
   Shaikh, A
   Gachuno, O
   Perrone, LA
   Murray, BL
   Berman, E
   Hansoti, B
AF McNabb, Scott J. N.
   Magowe, Mabel
   Shaw, Nadine
   Berrian, Amanda M.
   Wilkes, Michael
   Shaikh, Affan
   Gachuno, Onesmus
   Perrone, Lucy A.
   Murray, Brittany L.
   Berman, Eva
   Hansoti, Bhakti
TI Delivering Modern Global Health Learning Requires New Obligations and
   Approaches
SO ANNALS OF GLOBAL HEALTH
LA English
DT Article
ID SELF-REFLECTION
AB Introduction: The COVID-19 pandemic has forced a new look (or modernization) for both the obligations and approaches to achieve best-practices in global health learning. These best-practices have moved beyond traditional, face-to-face (F2F), classroom-based didactics to the use of innovative online, asynchronous and synchronous instructional design and the information and communication technology (ICT) tools to support it. But moving to this higher level of online in-service and pre-service training, key obligations (e.g., stopping neocolonialization, cultural humility, reversing brain drain, gender equity) must guide the modernization of instructional design and the supporting ICT. To positively impact global health training, educators must meet the needs of learners where they are.
   Purpose: We describe a set of multi-communication methods, e-Learning principles, strategies, and ICT approaches for educators to pivot content delivery from traditional, F2F classroom didactics into the modern era. These best-practices in both the obligations and approaches utilize thoughtful, modern strategies of instructional design and ICT.
   Approach: We harnessed our collective experiences in global health training to present thoughtful insights on the guiding principles, strategies, and ICT environment central to develop learning curricula that meet trainee needs and how they can be actualized. Specifically, we describe five strategies: 1. Individualized learning; 2. Provide experiential learning; 3. Mentor. Mentor. Mentor; 4. Reinforce learning through assessment; and 5. Information and communication technology and tools to support learning.
   Discussion: We offer a vision, set of guiding principles, and five strategies for successful curricula delivery in the modern era so that global health training can be made available to a wider audience more efficiently and effectively.
C1 [McNabb, Scott J. N.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
   [Magowe, Mabel] Univ Botswana, Sch Nursing, Gaborone, Botswana.
   [Shaw, Nadine] Univ Washington, Evans Sch Publ Policy & Governance, Seattle, WA 98195 USA.
   [Shaw, Nadine] Int Program Publ Hlth Leadership, Seattle, WA USA.
   [Berrian, Amanda M.] Ohio State Univ, Coll Vet Med, Columbus, OH 43210 USA.
   [Berrian, Amanda M.] Global One Hlth initiat, College Stn, TX USA.
   [Wilkes, Michael] Univ Calif Davis, Sch Med, Global Hlth, Davis, CA 95616 USA.
   [Shaikh, Affan] Yale Univ, Sch Management, New Haven, CT USA.
   [Gachuno, Onesmus] Univ Nairobi, Dept Obstet & Gynecol, Nairobi, Kenya.
   [Gachuno, Onesmus; Berman, Eva] Afya Bora Consortium, Kampala, Uganda.
   [Perrone, Lucy A.; Berman, Eva] Univ Washington, Dept Global Hlth, Seattle, WA USA.
   [Perrone, Lucy A.] Univ Washington, Dept Lab Med, Seattle, WA USA.
   [Perrone, Lucy A.] Int Training & Educ Ctr Hlth I TECH, Seattle, WA USA.
   [Murray, Brittany L.] Emory Univ Sch Med, Atlanta, GA USA.
   [Murray, Brittany L.] Childrens Healthcare Atlanta, Atlanta, GA USA.
   [Hansoti, Bhakti] Johns Hopkins Sch Med, Baltimore, MD USA.
   [Hansoti, Bhakti] STAR Program, New York, NY USA.
RP McNabb, SJN (通讯作者)，1513 Clifton Rd, Atlanta, GA 30333 USA.
EM scottjmcnabb@emory.edu
OI Shaikh, Affan/0000-0003-1583-3817; PERRONE. MSPH, PhD, LUCY
   A./0000-0003-2185-688X; Berrian, Amanda/0000-0002-9763-520X; Murray,
   Brittany/0000-0002-6201-6951
FU Afya Bora Consortium fellowship - U.S. President's Emergency Plan for
   AIDS Relief (PEPFAR) from the Health Resources and Services
   Administration (HRSA) Global HIV/AIDS Bureau [U91 HA06801]; United
   States Agency for International Development (USAID) [7200AA18CA00001]
FX This work was supported by 1) Afya Bora Consortium fellowship, which is
   funded by the U.S. President's Emergency Plan for AIDS Relief (PEPFAR)
   through funding to the University of Washington's International AIDS
   Education and Training Center (IAETC) under cooperative agreement U91
   HA06801 from the Health Resources and Services Administration (HRSA)
   Global HIV/AIDS Bureau and (2) the STAR project funded through
   Cooperative Agreement No. 7200AA18CA00001 by the United States Agency
   for International Development (USAID).
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NR 24
TC 1
Z9 1
U1 0
U2 3
PU UBIQUITY PRESS LTD
PI LONDON
PA 2N, 6 OSBORNE ST, LONDON, E1 6TD, ENGLAND
SN 2214-9996
J9 ANN GLOB HEALTH
JI Ann. Glob. Health
PY 2021
VL 87
IS 1
AR 68
DI 10.5334/aogh.3261
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA TJ7CF
UT WOS:000673634400005
PM 34307071
OA gold, Green Published
DA 2022-07-18
ER

PT J
AU Nehme, M
   Baysson, H
   Pullen, N
   Wisniak, A
   Pennacchio, F
   Zaballa, ME
   Fargnoli, V
   Kaiser, L
   Hurst, S
   Burton-Jeangros, C
   Stringhini, S
   Guessous, I
AF Nehme, Mayssam
   Baysson, Helene
   Pullen, Nick
   Wisniak, Ania
   Pennacchio, Francesco
   Zaballa, Maria-Eugenia
   Fargnoli, Vanessa
   Kaiser, Laurent
   Hurst, Samia
   Burton-Jeangros, Claudine
   Stringhini, Silvia
   Guessous, Idris
CA Specchio-COVID19 Study Grp
TI Perceptions of vaccination certificates among the general population in
   Geneva, Switzerland
SO SWISS MEDICAL WEEKLY
LA English
DT Article
AB OBJECTIVE: This study aimed to assess the public perception of COVID-19 vaccination certificates as well as potential differences between individuals.
   METHODS: Between 17 March and 1 April 2021, a self-administered online questionnaire was proposed to all persons aged 18 years and older participating in the longitudinal follow-up of SARS-CoV-2 seroprevalence studies in Geneva, Switzerland. The questionnaire covered aspects of individual and collective benefits, and allowed participants to select contexts in which vaccination certificates should be presented. Results were presented as the proportion of persons agreeing or disagreeing with the implementation of vaccination certificates, selecting specific contexts where certificates should be presented, and agreeing or disagreeing with the potential risks related to certificates. Logistic regression was used to calculate odds ratios for factors associated with certificate non-acceptance.
   RESULTS: Overall, 4067 individuals completed the questionnaire(response rate 77.4%; mean age 53.3 +/- standard deviation 14.4 years; 56.1% were women). About 61.0%of participants agreed or strongly agreed that a vaccination certificate was necessary in certain contexts and 21.6% believed there was no context where vaccination certificates should be presented. Contexts where a majority of participants perceived a vaccination certificate should be presented included jobs where others would be at risk of COVID-related complications (60.7%), jobs where employees would be at risk of getting infected (58.7%), or to be exempt from quarantine when travelling abroad(56.0%). Contexts where fewer individuals perceived the need for vaccination certificates to be presented were participation in large gatherings (36.9%), access to social venues (35.5%), or sharing the same workspace (21.5%).Younger age, no intent for vaccination, and not believing vaccination to be an important step in surmounting the pandemic were factors associated with certificate non-acceptance.
   CONCLUSION: This large population-based study showed that the general adult population in Geneva, Switzerland, agreed with the implementation of vaccination certificates in work-related and travel-related contexts. However, this solution was perceived as unnecessary for access to large gatherings or social venues, or to share the same workspace. Differences were seen with age,sex, education, socioeconomic status, and vaccination willingness and perception, highlighting the importance of taking personal and sociodemographic variation into consideration when predicting acceptance of such certificates.
C1 [Nehme, Mayssam; Guessous, Idris] Geneva Univ Hosp, Div & Dept Primary Care Med, Geneva, Switzerland.
   [Baysson, Helene; Pullen, Nick; Wisniak, Ania; Pennacchio, Francesco; Zaballa, Maria-Eugenia; Stringhini, Silvia] Geneva Univ Hosp, Div Primary Care Med, Unit Populat Epidemiol, Geneva, Switzerland.
   [Wisniak, Ania] Univ Geneva, Fac Med, Inst Global Hlth, Geneva, Switzerland.
   [Fargnoli, Vanessa; Burton-Jeangros, Claudine] Univ Geneva, Inst Sociol Res, Geneva, Switzerland.
   [Kaiser, Laurent] Geneva Univ Hosp, Div Lab Med, Geneva, Switzerland.
   [Kaiser, Laurent] Univ Geneva, Fac Med, Dept Med, Geneva, Switzerland.
   [Kaiser, Laurent] Geneva Univ Hosp, Geneva Ctr Emerging Viral Dis, Geneva, Switzerland.
   [Kaiser, Laurent] Geneva Univ Hosp, Lab Virol, Geneva, Switzerland.
   [Hurst, Samia] Univ Geneva, Fac Med, Inst Eth Hist & Humanities, Geneva, Switzerland.
   [Stringhini, Silvia; Guessous, Idris] Univ Geneva, Fac Med, Dept Hlth & Community Med, Geneva, Switzerland.
   [Stringhini, Silvia] Univ Lausanne, Univ Ctr Gen Med & Publ Hlth, Lausanne, Switzerland.
RP Nehme, M (通讯作者)，Hop Univ Geneve, CH-1205 Geneva, Switzerland.
EM mayssam.nehme@hcuge.ch
OI Baysson, Helene/0000-0003-4676-4500
FU Edmond J SAFRA foundation for clinical research in internal medicine;
   General Directorate of Health of the Department of Safety, Employment
   and Health of the canton of Geneva; Private Foundation of the Geneva
   University Hospitals; Swiss Federal Office of Public Health; Fondation
   des Grangettes; Swiss School of Public Health (Corona Immunitas Research
   Program)
FX This work was supported by the Edmond J SAFRA foundation for clinical
   research in internal medicine, the General Directorate of Health of the
   Department of Safety, Employment and Health of the canton of Geneva, the
   Private Foundation of the Geneva University Hospitals, the Swiss Federal
   Office of Public Health, the Swiss School of Public Health (Corona
   Immunitas Research Program) and the Fondation des Grangettes.
CR Aranzales I, SCI OPINIONS IMMUNIT
   Baysson H, SPECCHIO COVID19 STU
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NR 28
TC 1
Z9 1
U1 2
U2 2
PU E M H SWISS MEDICAL PUBLISHERS LTD
PI MUTTENZ
PA FARNSBURGERSTR 8, CH-4132 MUTTENZ, SWITZERLAND
SN 1424-7860
EI 1424-3997
J9 SWISS MED WKLY
JI Swiss Med. Wkly.
PD NOV 29
PY 2021
VL 151
AR w30079
DI 10.4414/SMW.2021.w30079
PG 30
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YU5DM
UT WOS:000752063500002
PM 34846113
OA gold
DA 2022-07-18
ER

PT J
AU Chen, HC
   Prasetyo, E
   Tseng, SS
   Putra, KT
   Prayitno
   Kusumawardani, SS
   Weng, CE
AF Chen, Hsing-Chung
   Prasetyo, Eko
   Tseng, Shian-Shyong
   Putra, Karisma Trinanda
   Prayitno
   Kusumawardani, Sri Suning
   Weng, Chien-Erh
TI Week-Wise Student Performance Early Prediction in Virtual Learning
   Environment Using a Deep Explainable Artificial Intelligence
SO APPLIED SCIENCES-BASEL
LA English
DT Article
DE imbalanced data distribution; explainable student performance
   prediction; feature importance
ID BLACK-BOX
AB Early prediction of students' learning performance and analysis of student behavior in a virtual learning environment (VLE) are crucial to minimize the high failure rate in online courses during the COVID-19 pandemic. Nevertheless, traditional machine learning models fail to predict student performance in the early weeks due to the lack of students' activities' data in a week-wise timely manner (i.e., spatiotemporal feature issues). Furthermore, the imbalanced data distribution in the VLE impacts the prediction model performance. Thus, there are severe challenges in handling spatiotemporal features, imbalanced data sets, and a lack of explainability for enhancing the confidence of the prediction system. Therefore, an intelligent framework for explainable student performance prediction (ESPP) is proposed in this study in order to provide the interpretability of the prediction results. First, this framework utilized a time-series weekly student activity data set and dealt with the VLE imbalanced data distribution using a hybrid data sampling method. Then, a combination of convolutional neural network (CNN) and long short-term memory (LSTM) was employed to extract the spatiotemporal features and develop the early prediction deep learning (DL) model. Finally, the DL model was explained by visualizing and analyzing typical predictions, students' activities' maps, and feature importance. The numerical results of cross-validation showed that the proposed new DL model (i.e., the combined CNN-LSTM and ConvLSTM), in the early prediction cases, performed better than the baseline models of LSTM, support vector machine (SVM), and logistic regression (LR) models.
C1 [Chen, Hsing-Chung; Prasetyo, Eko; Putra, Karisma Trinanda; Prayitno] Asia Univ, Dept Comp Sci & Informat Engn, Taichung 413, Taiwan.
   [Chen, Hsing-Chung] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan.
   [Prasetyo, Eko] Univ Muhammadiyah Yogyakarta, Dept Informat Technol, Bantul 55183, Indonesia.
   [Tseng, Shian-Shyong] Asia Univ, Dept M Commerce & Multimedia Applicat, Taichung 413, Taiwan.
   [Putra, Karisma Trinanda] Univ Muhammadiyah Yogyakarta, Dept Elect Engn, Bantul 55183, Indonesia.
   [Prayitno] Politekn Negeri Semarang, Dept Elect Engn, Semarang 50275, Indonesia.
   [Kusumawardani, Sri Suning] Univ Gadjah Mada, Dept Elect & Informat Engn, Yogyakarta 55281, Indonesia.
   [Weng, Chien-Erh] Natl Kaohsiung Univ Sci & Technol, Dept Telecommun Engn, Kaohsiung 811, Taiwan.
RP Chen, HC (通讯作者)，Asia Univ, Dept Comp Sci & Informat Engn, Taichung 413, Taiwan.; Chen, HC (通讯作者)，China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan.; Tseng, SS (通讯作者)，Asia Univ, Dept M Commerce & Multimedia Applicat, Taichung 413, Taiwan.; Weng, CE (通讯作者)，Natl Kaohsiung Univ Sci & Technol, Dept Telecommun Engn, Kaohsiung 811, Taiwan.
EM cdma2000@asia.edu.tw; eko.prasetyo@umy.ac.id; sstseng@asia.edu.tw;
   karisma@ft.umy.ac.id; prayitno@polines.ac.id; suning@ugm.ac.id;
   ceweng@nkust.edu.tw
RI Prasetyo, Eko/CAH-2400-2022; , Prayitno/AAU-8932-2021
OI , Prayitno/0000-0002-4794-2957; Prasetyo, Eko/0000-0001-9866-0813;
   Putra, Karisma/0000-0003-2887-3527; Weng, Chien Erh/0000-0002-0344-6038;
   Chen, Hsing-Chung/0000-0002-5266-9975
FU Ministry of Science and Technology (MOST), Taiwan, under MOST
   [110-2218-E-468-001-MBK, 110-2221-E-468-007, 110-2218-E-002-044];
   Ministry of Education [I109MD040]
FX This research was funded by the Ministry of Science and Technology
   (MOST), Taiwan, under MOST Grant Nos. 110-2218-E-468-001-MBK,
   110-2221-E-468-007, and 110-2218-E-002-044. This work was supported in
   part by the Ministry of Education under Grant No. I109MD040.
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   Zhou JH, 2021, EDUC SCI, V11, DOI 10.3390/educsci11050248
NR 39
TC 0
Z9 0
U1 6
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3417
J9 APPL SCI-BASEL
JI Appl. Sci.-Basel
PD FEB
PY 2022
VL 12
IS 4
AR 1885
DI 10.3390/app12041885
PG 16
WC Chemistry, Multidisciplinary; Engineering, Multidisciplinary; Materials
   Science, Multidisciplinary; Physics, Applied
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Chemistry; Engineering; Materials Science; Physics
GA 0F6GA
UT WOS:000777454400001
OA gold
DA 2022-07-18
ER

PT J
AU Fauk, NK
   Ziersch, A
   Gesesew, H
   Ward, P
   Green, E
   Oudih, E
   Tahir, R
   Mwanri, L
AF Fauk, Nelsensius Klau
   Ziersch, Anna
   Gesesew, Hailay
   Ward, Paul
   Green, Erin
   Oudih, Enaam
   Tahir, Roheena
   Mwanri, Lillian
TI Migrants and Service Providers' Perspectives of Barriers to Accessing
   Mental Health Services in South Australia: A Case of African Migrants
   with a Refugee Background in South Australia
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE mental healthcare services; mental health problems; barriers; African
   migrants; Australia
ID YOUNG-PEOPLE; KNOWLEDGE; DISORDER; NEEDS
AB International mobility has increased steadily in recent times, bringing along a myriad of health, social and health system challenges to migrants themselves and the host nations. Mental health issues have been identified as a significant problem among migrants, with poor accessibility and underutilisation of the available mental health services (MHSs) repeatedly reported, including in Australia. Using a qualitative inquiry and one-on-one in-depth interviews, this study explored perspectives of African migrants and service providers on barriers to accessing MHSs among African migrants in South Australia. The data collection took place during the COVID-19 pandemic with lockdown and other measures to combat the pandemic restricting face to face meetings with potential participants. Online platforms including Zoom and/or WhatsApp video calls were used to interview 20 African migrants and 10 service providers. Participants were recruited from community groups and/or associations, and organisations providing services for migrants and/or refugees in South Australia using the snowball sampling technique. Thematic framework analysis was used to guide the data analysis. Key themes centred on personal factors (health literacy including knowledge and the understanding of the health system, and poor financial condition), structural factors related to difficulties in navigating the complexity of the health system and a lack of culturally aware service provision, sociocultural and religious factors, mental health stigma and discrimination. The findings provide an insight into the experiences of African migrants of service provision to them and offer suggestions on how to improve these migrants' mental health outcomes in Australia. Overcoming barriers to accessing mental health services would need a wide range of strategies including education on mental health, recognising variations in cultures for effective service provision, and addressing mental health stigma and discrimination which strongly deter service access by these migrants. These strategies will facilitate help-seeking behaviours as well as effective provision of culturally safe MHSs and improvement in access to MHSs among African migrants.
C1 [Fauk, Nelsensius Klau; Ziersch, Anna; Gesesew, Hailay; Ward, Paul; Green, Erin; Tahir, Roheena; Mwanri, Lillian] Flinders Univ S Australia, Coll Med & Publ Hlth, Adelaide, SA 5042, Australia.
   [Fauk, Nelsensius Klau] Inst Resource Governance & Social Change, Jl RW Monginsidi II 2, Kupang 85221, Indonesia.
   [Oudih, Enaam] Relationships Australia, Adelaide, SA 5007, Australia.
RP Mwanri, L (通讯作者)，Flinders Univ S Australia, Coll Med & Publ Hlth, Adelaide, SA 5042, Australia.
EM nelsensius.fauk@flinders.edu.au; Anna.ziersch@flinders.edu.au;
   Hailay.gesesew@flinders.edu.au; paul.ward@flinders.edu.au;
   Erin.green@flinders.edu.au; E.Oudih@rasa.org.au;
   roheena.tahir@flinders.edu.au; lillian.mwanri@flinders.edu.au
RI Fauk, Nelsensius Klau/L-8024-2015; Mwanri, Lillian/AGG-3711-2022
OI Fauk, Nelsensius Klau/0000-0002-1325-2640; Gesesew,
   Hailay/0000-0002-3531-4400; Ward, Paul/0000-0002-5559-9714; Mwanri,
   Lillian/0000-0002-5792-7785
FU Flinders University; Flinders Health Foundation in South Australia
FX This research was funded by small collaborative grants by Flinders
   University and Flinders Health Foundation in South Australia. The
   funders did not have any involvement in the design, data collection,
   data analysis and interpretation or writing of the paper.
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NR 57
TC 1
Z9 1
U1 5
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD SEP
PY 2021
VL 18
IS 17
AR 8906
DI 10.3390/ijerph18178906
PG 21
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA UP7NH
UT WOS:000695562500001
PM 34501496
OA gold, Green Published
DA 2022-07-18
ER

PT J
AU Helminen, EC
   Scheer, JR
   Jackson, SD
   Brisbin, CD
   Batchelder, AW
   Cascalheira, CJ
   Sullivan, TP
AF Helminen, Emily C.
   Scheer, Jillian R.
   Jackson, Skyler D.
   Brisbin, Cal D.
   Batchelder, Abigail W.
   Cascalheira, Cory J.
   Sullivan, Tami P.
TI PTSD Symptoms and Hazardous Drinking Indicators among Trauma-Exposed
   Sexual Minority Women during Heightened Societal Stress
SO BEHAVIORAL MEDICINE
LA English
DT Article; Early Access
DE alcohol use disorder; heavy episodic drinking; PTSD symptoms; sexual
   minority women; trauma
ID SUBSTANCE USE DISORDERS; ALCOHOL-USE DISORDERS; POSTTRAUMATIC-STRESS;
   MENTAL-HEALTH; DRUG-USE; HETEROSEXUAL WOMEN; ANXIETY DISORDERS;
   AFRICAN-AMERICAN; SELF-MEDICATION; USE BEHAVIORS
AB Trauma-exposed sexual minority women (SMW) are at elevated risk of posttraumatic stress disorder (PTSD) and hazardous drinking compared to trauma-exposed heterosexual women. To understand whether these problems might be exacerbated during times of elevated societal stress, we collected data from a New York-based sample of trauma-exposed SMW between April 2020 and August 2020, a period of notable, compounding societal stressors, including: (a) living in or near one of the first epicenters of the coronavirus disease 2019 (COVID-19) epidemic in the United States and (b) living through multiple high-profile occurrences of racism-related police violence and subsequent racial unrest. SMW (n = 68) completed online self-report questionnaires related to trauma, PTSD symptoms, and alcohol use, and a subset (n = 29) completed semi-structured qualitative interviews. PsycINFO was searched with terms related to SMW, PTSD, and alcohol use to identify studies with samples of SMW from articles published within the last 10 years to which we could compare our sample; this produced nine studies. Welch's t-tests and Chi-square analyses revealed that SMW within our sample reported significantly higher PTSD symptom severity, probable PTSD, and hazardous drinking indicators (i.e., alcohol use disorder and heavy episodic drinking) between April 2020 and August 2020 compared to similar samples (i.e., trauma-exposed SMW and general samples of SMW) assessed previously. Qualitative reports also indicated that the societal stressors of 2020 contributed to mental and behavioral health concerns. These results underscore the need for integrated PTSD and alcohol use prevention and intervention efforts for trauma-exposed SMW during times of heightened societal stress. Supplemental data for this article is available online at https://doi.org/10.1080/08964289.2021.2006132 .
C1 [Helminen, Emily C.; Scheer, Jillian R.; Brisbin, Cal D.; Cascalheira, Cory J.] Syracuse Univ, Dept Psychol, 414 Huntington Hall, Syracuse, NY 13244 USA.
   [Jackson, Skyler D.] Yale Univ, Dept Social & Behav Sci, Sch Publ Hlth, New Haven, CT USA.
   [Brisbin, Cal D.] Univ Calif New Haven, Luskin Sch Publ Affairs, New Haven, CT USA.
   [Batchelder, Abigail W.] Harvard Univ, Harvard Med Sch, Boston, MA USA.
   [Batchelder, Abigail W.] Massachusetts Gen Hosp, Dept Psychiat, Behavioral Med Program, Boston, MA USA.
   [Batchelder, Abigail W.] Fenway Hlth, Fenway Inst, Boston, MA USA.
   [Cascalheira, Cory J.] New Mexico State Univ, Dept Counseling & Educ Psychol, Boston, MA USA.
   [Sullivan, Tami P.] Yale Univ, Dept Psychiat, Sch Med, New Haven, CT USA.
RP Scheer, JR (通讯作者)，Syracuse Univ, Dept Psychol, 414 Huntington Hall, Syracuse, NY 13244 USA.
EM jrscheer@syr.edu
OI Helminen, Emily/0000-0002-3884-9603; Jackson,
   Skyler/0000-0002-0353-7992; Brisbin, Cal/0000-0002-7554-9140;
   Cascalheira, Cory/0000-0001-5780-3101; Scheer, Jillian
   R./0000-0002-7311-5904; Sullivan, Tami/0000-0002-4981-1168; Batchelder,
   Abigail/0000-0001-7225-1675
FU Yale University Women's Faculty Forum Seed Grant; Yale University's Fund
   for Lesbian and Gay Studies
FX This study was funded by the Yale University Women's Faculty Forum Seed
   Grant and Yale University's Fund for Lesbian and Gay Studies (PI:
   Scheer). The content contained herein is the authors' own and does not
   necessarily reflect the views of the funders.
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   Whittington C., LIVES LIVELIHOODS MA
NR 71
TC 0
Z9 0
U1 4
U2 4
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0896-4289
EI 1940-4026
J9 BEHAV MED
JI Behav. Med.
DI 10.1080/08964289.2021.2006132
EA NOV 2021
PG 12
WC Behavioral Sciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Psychiatry
GA XK0RB
UT WOS:000727182100001
PM 34870567
DA 2022-07-18
ER

PT J
AU Garrett, ME
   Galloway, J
   Chu, HY
   Itell, HL
   Stoddard, CI
   Wolf, CR
   Logue, JK
   McDonald, D
   Matsen, FA
   Overbaugh, J
AF Garrett, Meghan E.
   Galloway, Jared
   Chu, Helen Y.
   Itell, Hannah L.
   Stoddard, Caitlin, I
   Wolf, Caitlin R.
   Logue, Jennifer K.
   McDonald, Dylan
   Matsen, Frederick A.
   Overbaugh, Julie
TI High-resolution profiling of pathways of escape for SARS-CoV-2
   spike-binding antibodies
SO CELL
LA English
DT Article
ID NEUTRALIZING ANTIBODIES; MUTATIONS; DOMAIN; PROTEIN; SITES
AB Defining long-term protective immunity to SARS-CoV-2 is one of the most pressing questions of our time and will require a detailed understanding of potential ways this virus can evolve to escape immune protection. Immune protection will most likely be mediated by antibodies that bind to the viral entry protein, spike (S). Here, we used Phage-DMS, an approach that comprehensively interrogates the effect of all possible mutations on binding to a protein of interest, to define the profile of antibody escape to the SARS-CoV-2 S protein using coronavirus disease 2019 (COVID-19) convalescent plasma. Antibody binding was common in two regions, the fusion peptide and the linker region upstream of the heptad repeat region 2. However, escape mutations were variable within these immunodominant regions. There was also individual variation in less commonly targeted epitopes. This study provides a granular view of potential antibody escape pathways and suggests there will be individual variation in antibody-mediated virus evolution.
C1 [Garrett, Meghan E.; Itell, Hannah L.; Stoddard, Caitlin, I; Overbaugh, Julie] Fred Hutchinson Canc Res Ctr, Div Human Biol, 1124 Columbia St, Seattle, WA 98104 USA.
   [Garrett, Meghan E.; Itell, Hannah L.] Univ Washington, Mol & Cellular Biol Grad Program, Seattle, WA 98195 USA.
   [Garrett, Meghan E.; Itell, Hannah L.] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA.
   [Galloway, Jared; Matsen, Frederick A.; Overbaugh, Julie] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
   [Chu, Helen Y.; Wolf, Caitlin R.; Logue, Jennifer K.; McDonald, Dylan] Univ Washington, Dept Med, Seattle, WA USA.
   [Matsen, Frederick A.] Fred Hutchinson Canc Res Ctr, Computat Biol Program, 1124 Columbia St, Seattle, WA 98104 USA.
RP Overbaugh, J (通讯作者)，Fred Hutchinson Canc Res Ctr, Div Human Biol, 1124 Columbia St, Seattle, WA 98104 USA.; Overbaugh, J (通讯作者)，Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
EM joverbau@fredhutch.org
RI Logue, Jennifer K/GLS-7202-2022; Logue, Jennifer K/GLS-1307-2022
OI Logue, Jennifer K/0000-0002-7889-8960; Logue, Jennifer
   K/0000-0002-7889-8960; Itell, Hannah/0000-0001-8296-8645
FU NIH [AI138709, R01 AI146028, U19 AI128914]; Endowed Chair for Graduate
   Education (FHCRC); Howard Hughes Medical Institute; Simons Foundation
FX We gratefully acknowledge Kevin Sung for helpful discussion and
   Katherine H.D. Crawford for the Python code used to generate the
   oligonucleotide library sequences. We thank Sarah K. Hilton, John
   Huddleston, and Jesse D. Bloom for developing and demonstrating the
   dms-view online tool. We thank the Fred Hutch Genomics core facility, in
   particular Cassie Sather, for assistance with sequencing. This work was
   funded by NIH grants AI138709 (principal investigator [PI] J.O.), R01
   AI146028, and U19 AI128914 (PI F.A.M.). J.O. received support as the
   Endowed Chair for Graduate Education (FHCRC). The research of F.A.M. was
   supported in part by a Faculty Scholar grant from the Howard Hughes
   Medical Institute and the Simons Foundation.
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NR 52
TC 5
Z9 5
U1 2
U2 6
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 0092-8674
EI 1097-4172
J9 CELL
JI Cell
PD MAY 27
PY 2021
VL 184
IS 11
BP 2927
EP +
DI 10.1016/j.cell.2021.04.045
EA MAY 2021
PG 23
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA SL5NT
UT WOS:000656965600011
OA Green Submitted, Green Published
DA 2022-07-18
ER

PT J
AU Ong, J
   Lim, WY
   Doshi, K
   Zhou, M
   Sng, BL
   Tan, LH
   Ong, S
AF Ong, John
   Lim, Wan Yen
   Doshi, Kinjal
   Zhou, Man
   Sng, Ban Leong
   Tan, Li Hoon
   Ong, Sharon
TI An Evaluation of the Performance of Five Burnout Screening Tools: A
   Multicentre Study in Anaesthesiology, Intensive Care, and Ancillary
   Staff
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE burnout; burn out; stress; screening; diagnosis
ID MASLACH BURNOUT; SINGLE-ITEM; PHYSICIAN BURNOUT; INVENTORY; VALIDITY
AB Burnout is an important occupational hazard and early detection is paramount in preventing negative sequelae in physicians, patients, and healthcare systems. Several screening tools have been developed to replace lengthy diagnostic tools for large-scale screening, however, comprehensive head-to-head evaluation for performance and accuracy are lacking. The primary objective of this study was to compare the diagnostic performance of five burnout screening tools, including a novel rapid burnout screening tool (RBST). This was a cross-sectional study involving 493 hospital staff (anaesthesiology and intensive care doctors, nurses, and ancillary staff) at the COVID-19 frontline across four hospitals in Singapore between December 2020 and April 2021. The Maslach Burnout Inventory-Human Services Survey (MBI-HSS) was used as the reference standard. Five burnout screening tools, the single-item MBI measure of burnout (SI-MBI), dual-item MBI (DI-MBI), abbreviated MBI (aMBI), Single Item Burnout Question (SIBOQ), and the RBST, were administered via a 36-item online survey. Tools were administered simultaneously and responses were anonymised. Burnout prevalence was 19.9%. The RBST and the SI-MBI had the two highest accuracies (87.8% and 81.9% respectively) and AUROC scores (0.86, 95% CI: 0.83-0.89 and 0.86, 95% CI: 0.82-0.89 respectively). However, the accuracy of the RBST was significantly higher than the SI-MBI (p < 0.0001), and it had the highest positive likelihood ratio (+LR = 7.59, 95% CI 5.65-10.21). Brief screening tools detect burnout albeit with a wide range of accuracy. This can strain support services and resources. The RBST is a free screening tool that can detect burnout with a high degree of accuracy.
C1 [Ong, John] Univ Cambridge, Dept Engn, Cambridge CB2 1PZ, England.
   [Ong, John] Natl Univ Singapore, Dept Med, Singapore 117597, Singapore.
   [Lim, Wan Yen; Ong, Sharon] Singhlth Serv, Sengkang Gen Hosp, Dept Anaesthesiol, Singapore 544886, Singapore.
   [Lim, Wan Yen] Singhlth Serv, Sengkang Gen Hosp, Dept Anaesthesiol, Singapore 169608, Singapore.
   [Doshi, Kinjal] Singhlth Serv, Sengkang Gen Hosp, Dept Psychol, Singapore 169608, Singapore.
   [Zhou, Man] Kings Coll London, GKT Sch Med Educ, London WCR 2LS, England.
   [Sng, Ban Leong] Singhlth Serv, KK Womens & Childrens Hosp, Dept Womens Anaesthesia, Singapore 229899, Singapore.
   [Sng, Ban Leong; Ong, Sharon] Duke NUS Med Sch, Singapore 169857, Singapore.
   [Tan, Li Hoon] Singhlth Serv, Changi Gen Hosp, Dept Anaesthesia & Surg Intens Care, Singapore 529889, Singapore.
   [Ong, Sharon] Singhlth Serv, Singapore Gen Hosp, Dept Surg Intens Care, Singapore 169608, Singapore.
RP Ong, J (通讯作者)，Univ Cambridge, Dept Engn, Cambridge CB2 1PZ, England.; Ong, J (通讯作者)，Natl Univ Singapore, Dept Med, Singapore 117597, Singapore.; Ong, S (通讯作者)，Singhlth Serv, Sengkang Gen Hosp, Dept Anaesthesiol, Singapore 544886, Singapore.; Ong, S (通讯作者)，Duke NUS Med Sch, Singapore 169857, Singapore.; Ong, S (通讯作者)，Singhlth Serv, Singapore Gen Hosp, Dept Surg Intens Care, Singapore 169608, Singapore.
EM jo401@cam.ac.uk; lim.wan.yen@singhealth.com.sg; kinjal.doshi@gmail.com;
   man.zhou@kcl.ac.uk; sng.ban.leong@singhealth.com.sg;
   tan.li.hoon@singhealth.com.sg; sharon.ong.g.k@singhealth.com.sg
OI Lim, Wan Yen/0000-0002-0335-0255; Ong, John/0000-0001-5103-7311
FU Singhealth Duke-NUS Academic Medical Centre and a Singapore General
   Hospital Division of Anaesthesiology and Perioperative Medicine Budding
   Research [ANAESBRG/2020/002]; Sengkang General Hospital; W D Armstrong
   doctoral research training fellowship; National University of Singapore
FX This research was funded by the Singhealth Duke-NUS Academic Medical
   Centre and a Singapore General Hospital Division of Anaesthesiology and
   Perioperative Medicine Budding Research Grant, grant number
   ANAESBRG/2020/002, and the APC was funded by Sengkang General Hospital.
   JO is funded by a W D Armstrong doctoral research training fellowship at
   the University of Cambridge and a development grant from the National
   University of Singapore.
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   World Health Organization, BURN OUT OCC PHEN IN
NR 38
TC 1
Z9 1
U1 6
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD NOV
PY 2021
VL 10
IS 21
AR 4836
DI 10.3390/jcm10214836
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA WX4RW
UT WOS:000718586000001
PM 34768357
OA Green Published, gold
DA 2022-07-18
ER

PT J
AU Tavares, AI
AF Tavares, Aida Isabel
TI Self-assessed health among older people in Europe and internet use
SO INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
LA English
DT Article
DE Older people; Internet; Self-assessed health; Socioeconomic status;
   Europe
ID RATED HEALTH; REPORTED HEALTH; DETERMINANTS; ADULTS; ONLINE
AB Background: About ten years ago, an age-related digital divide was identified, where 'the elderly' denoted a group of people at risk of losing the benefits of a digital society. The aims of this work are to find a relationship between self-assessed health and internet use by older people in European countries and to ascertain whether this relationship differs in countries with a more developed eHealth policy.
   Materials and methods: An ordered logistic regression is estimated for all countries in the sample and for two countries subsets which differ in their eHealth performance. Individual data is collected by SHARE. The classifying criterion of eHealth performance is based on the 'eHealth' policy dimension of the indicator used to construct the Digital Economy and Society Index. The average marginal effects are computed for the variable of internet use.
   Results: Results show that older people who use the internet tend to report better health status. This relationship however may not hold for low levels of health and it is stronger in countries with low eHealth performance.
   Conclusion: Policy measures on eHealth not only contribute to people's health but also help to alleviate critical situations such as the one created by the Covid-19 pandemic.
C1 [Tavares, Aida Isabel] Univ Lisbon, Lisbon Sch Econ & Management, ISEG, Lisbon, Portugal.
   [Tavares, Aida Isabel] Univ Coimbra, CEISUC, Ctr Study & Res Hlth, Coimbra, Portugal.
RP Tavares, AI (通讯作者)，Univ Lisbon, Lisbon Sch Econ & Management, ISEG, Lisbon, Portugal.
EM atavares@iseg.ulisboa.pt
OI Tavares, Aida Isabel/0000-0003-3487-1202
FU European Commission [QLK6-CT-2001-00360, SHARE-I3: RII-CT-2006-062193,
   COMPARE: CIT5-CT-2005-028857, SHARELIFE: CIT4-CT-2006-028812, 211909,
   227822, 261982]; German Ministry of Education and Research; Max Planck
   Society for the Advancement of Science; U.S. National Institute on
   Ageing [U01_AG09740-13S2, P01_AG005842, P01_AG08291, P30_AG12815,
   R21_AG025169, Y1-AG-4553-01, IAG_BSR06-11, OGHA_04-064,
   HHSN271201300071C]; SHARE Project
FX The SHARE data collection has been primarily funded by the European
   Commission through FP5 (QLK6-CT-2001-00360), FP6 (SHARE-I3:
   RII-CT-2006-062193, COMPARE: CIT5-CT-2005-028857, SHARELIFE:
   CIT4-CT-2006-028812) and FP7 (SHARE-PREP: No211909, SHARE-LEAP:
   No227822, SHARE M4: No261982). Additional funding from the German
   Ministry of Education and Research, the Max Planck Society for the
   Advancement of Science, the U.S. National Institute on Ageing
   (U01_AG09740-13S2, P01_AG005842, P01_AG08291, P30_AG12815, R21_AG025169,
   Y1-AG-4553-01, IAG_BSR06-11, OGHA_04-064, HHSN271201300071C) and from
   various national funding sources is gratefully acknowledged (SHARE
   Project 2019).
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NR 53
TC 4
Z9 4
U1 11
U2 34
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1386-5056
EI 1872-8243
J9 INT J MED INFORM
JI Int. J. Med. Inform.
PD SEP
PY 2020
VL 141
AR 104240
DI 10.1016/j.ijmedinf.2020.104240
PG 8
WC Computer Science, Information Systems; Health Care Sciences & Services;
   Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Computer Science; Health Care Sciences & Services; Medical Informatics
GA OD3VH
UT WOS:000579780700052
PM 32739610
OA Green Published, Bronze
DA 2022-07-18
ER

PT J
AU Hadianfard, AM
   Mozaffari-Khosravi, H
   Karandish, M
   Azhdari, M
AF Hadianfard, Ali Mohammad
   Mozaffari-Khosravi, Hassan
   Karandish, Majid
   Azhdari, Maryam
TI Physical activity and sedentary behaviors (screen time and homework)
   among overweight or obese adolescents: a cross-sectional observational
   study in Yazd, Iran
SO BMC PEDIATRICS
LA English
DT Article
DE Overweight or obesity; Adolescents; Physical activity; Sedentary
   behaviors; Screen time
ID SCHOOL-AGED CHILDREN; NATIONAL-SURVEY; DIETARY HABITS; LEISURE-TIME;
   PREVALENCE
AB Background The growing number of adolescents who are overweight or obese (OW / OB) is a public concern. The present study was aimed to evaluate physical activity (PA) and sedentary behaviors (SB) (screen time (ST) and homework time (HT)) among Yazd OW/OB adolescents. Methods This cross-sectional study was performed among 510 students aged 12-16 in Yazd, Iran. The general information, PA, and SB (ST and HT) were collected by interview based on the WHO standard questionnaire. Anthropometric data were assessed by precise instruments. Daily energy intake (Energy) was obtained from a 7-day food record. Nutritionist 4 software (version I) was run to estimate the energy. Results There was a high prevalence of SB > 2h/day (97.6), ST > 2h/day (70.3%), overweight or obesity (40%), abdominal obesity (36.9%), physical inactivity (29.8%) among the students. The younger age (p = 0.014), energy (p < 0.001), no access to the yard (p < 0.001), family size <= 2 (p = 0.023), passive transportation, (p = 0.001), the highest school days' HT (p = 0.033) and SB (p = 0.021), and the highest weekends' HT among the students were the risk factors for OW/OB. The highest PA level was associated with a lower risk of OW/OB (p < 0.001). The findings were not the same in both sexes. Compared to the normal weight students, OW / OB spent more time on school days and weekdays for ST (P <0.001), HT (P <0.001, P = 0.005) and SB (P <0.001), respectively. OW/OB students showed a higher weekends' ST (p < 0.001) and lower HT (p = 0.048) than normal-weight students. Conclusion The prevalence of SB, ST, OW/OB, and physical inactivity were common. The school days and weekends' HT, the school days' SB and HT, age, energy, PA, and access to the yard, family size, and passive transportation were related to the greater chances of OW/OB students. Given that the expansion of online education and self-isolation in a new situation with COVID-19, it seems we will meet the worrying results.
C1 [Hadianfard, Ali Mohammad] Ahvaz Jundishapur Univ Med Sci, Sch Allied Med Sci, Dept Hlth Informat Technol, Ahvaz, Iran.
   [Mozaffari-Khosravi, Hassan; Azhdari, Maryam] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran.
   [Karandish, Majid] Ahvaz Jundishapur Univ Med Sci, Diabet Res Ctr, Hlth Res Inst, Ahvaz, Iran.
RP Azhdari, M (通讯作者)，Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran.
EM azhdari_mar@yahoo.com
RI Hadianfard, Ali Mohammad/E-2561-2010
OI Hadianfard, Ali Mohammad/0000-0002-7225-2990
CR Adeniyi Ade F, 2011, Child Adolesc Psychiatry Ment Health, V5, P16, DOI 10.1186/1753-2000-5-16
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NR 23
TC 1
Z9 1
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2431
J9 BMC PEDIATR
JI BMC Pediatr.
PD SEP 23
PY 2021
VL 21
IS 1
AR 421
DI 10.1186/s12887-021-02892-w
PG 10
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA UU2UG
UT WOS:000698655700004
PM 34556070
OA Green Published, gold
DA 2022-07-18
ER

PT J
AU Struwe, C
   Golinski, M
   Grimm, C
   Dickel, S
   Grummich, K
   Nothacker, M
   Voigt-Radloff, S
   Meerpohl, J
   Moerer, O
AF Struwe, Claudia
   Golinski, Martin
   Grimm, Clemens
   Dickel, Steffen
   Grummich, Kathrin
   Nothacker, Monika
   Voigt-Radloff, Sebastian
   Meerpohl, Jorg
   Moerer, Onnen
CA CEOsys Network
TI A Comparison and Evaluation of International Guidelines on the Treatment
   of Severe SARS-CoV-2 Infection
SO DEUTSCHES ARZTEBLATT INTERNATIONAL
LA English
DT Article
AB Background: When the SARS-CoV-2 pandemic began, no uniform treatment and care strategies for critically ill COVID-19 patients were yet available. National and international treatment recommendations were formulated under time pressure, initially on the basis of indirect evidence from the treatment of similar diseases. In this article, we give an overview of the content, currency, and methodological quality of the existing national and international guidelines, with special attention to the care of critically ill patients. Methods: Guidelines were identified by a comprehensive search, the included guidelines were assessed in standardized fashion with the AGREE II guideline assessment instrument and according to the AMWF rulebook criteria, and the core recommendations of the included and methodologically high-quality guidelines were compared. Results: Nine of the 97 guidelines that were identified fulfilled the content criteria for inclusion, and 6 of these fulfilled the qualitative criteria; these 6 guidelines still differed, however, in the topics to which they devoted the most attention, as well as in their methodological quality and currency. The treatment strategies for patients with severe respiratory failure (lung-protective ventilation strategies and rescue measures) deviated little from established standards. Uniform recommendations were made, among other things, for the administration of dexamethasone, which was recommended in all of the guidelines for patients requiring oxygen treatment, as well as for antithrombotic drug prophylaxis and for the prone positioning of ventilated patients. Many recommendations were based on insufficient evidence, and some were contradictory, e.g., those regarding antibiotic treatment or the choice between high-flow oxygen administration via nasal canula (HFNC) and noninvasive ventilation (NIV). Conclusion: The consultation of multiple high-quality international guidelines and guideline recommendations shared in online portals such as MagicApp are helpful sources of information for clinicians. In view of the continuing lack of strong evidence, further research on intensive care treatments is needed (aspects of ventilation, positioning therapy, and the role of extracorporeal membrane oxygenation [ECMO]).
C1 [Struwe, Claudia; Golinski, Martin; Grimm, Clemens; Dickel, Steffen; Moerer, Onnen] Univ Med Ctr Gottingen, Dept Anesthesiol, Gottingen, Germany.
   [Grummich, Kathrin; Meerpohl, Jorg] Univ Freiburg, Med Ctr, Inst Evidence Med, Freiburg, Germany.
   [Nothacker, Monika] Philipps Univ Marburg, AWMF Inst Med Knowledge Management, Marburg, Germany.
   [Voigt-Radloff, Sebastian] Univ Freiburg, Fac Med, Cochrane Germany Fdn, Inst Evidence Med, Freiburg, Germany.
   [Voigt-Radloff, Sebastian] Univ Freiburg, Med Ctr, Freiburg, Germany.
RP Moerer, O (通讯作者)，Univ Med Gottingen, Klin Anasthesiol, Robert Koch Str 40, D-37075 Gottingen, Germany.
EM omoerer@med.uni-goettingen.de
FU German Federal Ministry of Education and Research (BMBF) [FKZ 01KX2021]
FX This study was facilitated and conducted within the framework of the
   CEO-sys network Germany (COVID ecosystem) which is funded by the German
   Federal Ministry of Education and Research (BMBF) . [FKZ 01KX2021] .
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NR 33
TC 0
Z9 0
U1 2
U2 2
PU DEUTSCHER AERZTE-VERLAG GMBH
PI COLOGNE
PA DIESELSTRABE 2, POSTFACH 400265, D-50859 COLOGNE, GERMANY
SN 1866-0452
J9 DTSCH ARZTEBL INT
JI Dtsch. Arztebl. Int.
PD JAN 21
PY 2022
VL 119
IS 3
BP 23
EP +
DI 10.3238/arztebl.m2022.0006
PG 23
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 0Y6ZB
UT WOS:000790535800001
PM 34939920
OA Green Published, Bronze
DA 2022-07-18
ER

PT J
AU Elavsky, S
   Jandackova, V
   Knapova, L
   Vasendova, V
   Sebera, M
   Kastovska, B
   Blaschova, D
   Kuhnova, J
   Cimler, R
   Vilimek, D
   Bosek, T
   Koenig, J
   Jandacka, D
AF Elavsky, S.
   Jandackova, V.
   Knapova, L.
   Vasendova, V.
   Sebera, M.
   Kastovska, B.
   Blaschova, D.
   Kuhnova, J.
   Cimler, R.
   Vilimek, D.
   Bosek, T.
   Koenig, J.
   Jandacka, D.
TI Physical activity in an air-polluted environment: behavioral,
   psychological and neuroimaging protocol for a prospective cohort study
   (Healthy Aging in Industrial Environment study - Program 4)
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Air pollution; Environment; Physical activity; Health; Cognition;
   Neuroimaging; Aging
ID ECOLOGICAL MOMENTARY ASSESSMENT; DEPRESSED MOOD CONSISTENCY; COGNITIVE
   DECLINE; MOBILE-TECHNOLOGY; HAIR CORTISOL; EXPOSURE; ADULTS;
   METAANALYSIS; DEMENTIA; ANXIETY
AB BackgroundAir pollution has been linked to increased mortality and morbidity. The Program 4 of the Healthy Aging in Industrial Environment study investigates whether the health and wellbeing benefits of physical activity (PA) can be fully realized in individuals living in highly polluted environments. Herein, we introduce the behavioral, psychological and neuroimaging protocol of the study.MethodsThis is a prospective cohort study of N=1500 individuals aged 18-65years comparing: (1) individuals living in the highly polluted, industrial region surrounding the city of Ostrava (n=750), and (2) controls from the comparison region with relative low pollution levels in Southern Bohemia (n=750). Quota sampling is used to obtain samples balanced on age, gender, PA status (60% active runners vs. 40% insufficiently active). Participants are screened and complete baseline assessments through online questionnaires and in-person lab-based assessments of physiological, biomechanical, neuroimaging and cognitive function parameters. Prospective 12-month intensive monitoring of air pollution and behavioral parameters (PA, inactivity, and sleep) follows, with a focus on PA-related injuries and psychological factors through fitness trackers, smartphones, and mobile apps. Subsequently, there will be a 5-year follow-up of the study cohort.DiscussionThe design of the study will allow for (1) the assessment of both short-term variation and long-term change in behavioral parameters, (2) evaluation of the incidence of musculoskeletal injuries and psychological factors impacting behavior and injury recovery, and (3) the impact that air pollution status (and change) has on behavior, psychological resilience, and injury recovery. Furthermore, the integration of MRI techniques and cognitive assessment in combination with data on behavioral, biological and environmental variables will provide an opportunity to examine brain structure and cognitive function in relation to health behavior and air pollution, as well as other factors affecting resilience against and vulnerability to adverse changes in brain structure and cognitive aging. This study will help inform individuals about personal risk factors and decision-makers about the impact of environmental factors on negative health outcomes and potential underlying biological, behavioral and psychological mechanisms. Challenges and opportunities stemming from the timing of the study that coincided with the COVID-19 pandemic are also discussed.
C1 [Elavsky, S.; Jandackova, V.; Knapova, L.; Vasendova, V.; Sebera, M.; Kastovska, B.; Blaschova, D.; Vilimek, D.; Bosek, T.; Jandacka, D.] Univ Ostrava, Fac Educ, Ostrava, Czech Republic.
   [Elavsky, S.; Knapova, L.] Masaryk Univ, Fac Informat, Brno, Czech Republic.
   [Jandackova, V.] Univ Ostrava, Fac Med, Ostrava, Czech Republic.
   [Kuhnova, J.; Cimler, R.] Univ Hradec Kralove, Fac Life Sci, Hradec Kralove, Czech Republic.
   [Vilimek, D.] VSB Tech Univ Ostrava, Ostrava, Czech Republic.
   [Koenig, J.] Univ Bern, Univ Hosp Child & Adolescent Psychiat & Psychothe, Bern, Switzerland.
   [Koenig, J.] Heidelberg Univ, Sect Expt Child & Adolescent Psychiat, Dept Child & Adolescent Psychiat, Ctr Psychosocial Med, Heidelberg, Germany.
RP Elavsky, S (通讯作者)，Univ Ostrava, Fac Educ, Ostrava, Czech Republic.; Elavsky, S (通讯作者)，Masaryk Univ, Fac Informat, Brno, Czech Republic.
EM steriani.elavsky@osu.cz
RI Elavsky, Steriani/GLS-6759-2022; Jandacka, Daniel/B-6035-2011;
   Blaschova, Denisa/ABF-6745-2021; Knapová, Lenka/GLQ-7644-2022; Koenig,
   Julian/J-8863-2017
OI Elavsky, Steriani/0000-0002-5070-0481; Jandacka,
   Daniel/0000-0003-2653-2569; Knapová, Lenka/0000-0002-1366-8961; Koenig,
   Julian/0000-0003-1009-9625; Vilimek, Dominik/0000-0003-3781-1280
FU European Union [CZ.02.1.01/0.0/0.0/16_019/0000798]; Ministry of
   Education, Youth and Sports of the Czech Republic
FX This publication was based on the information (data) provided from the
   Program 4 within the research project designated (named) "Healthy Aging
   in Industrial Environment HAIE" with registration number of
   CZ.02.1.01/0.0/0.0/16_019/0000798, which was funded by the European
   Union and provided by the Ministry of Education, Youth and Sports of the
   Czech Republic. The mentioned information (data) was obtained (gathered)
   by the Department of Human Movement Studies, The Human Motion Diagnostic
   Center, University of Ostrava, Ostrava, Czech Republic.
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NR 100
TC 3
Z9 4
U1 8
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JAN 12
PY 2021
VL 21
IS 1
AR 126
DI 10.1186/s12889-021-10166-4
PG 14
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA PU7TE
UT WOS:000609502800001
PM 33435943
OA Green Published, gold
DA 2022-07-18
ER

PT J
AU Nnodu, OE
   Osei-Akoto, A
   Nembaware, V
   Kent, J
   Nwegbu, M
   Minja, I
   Mazandu, GK
   Makani, J
   Wonkam, A
AF Nnodu, Obiageli Eunice
   Osei-Akoto, Alex
   Nembaware, Victoria
   Kent, Jill
   Nwegbu, Maxwell
   Minja, Irene
   Mazandu, Gaston Kuzamunu
   Makani, Julie
   Wonkam, Ambroise
TI Skills Capacity Building For Health Care Services and Research Through
   the Sickle Pan African Research Consortium
SO FRONTIERS IN GENETICS
LA English
DT Article
DE capacity building; health care; research; data management; sickle cell
   disease; Africa
ID CELL-DISEASE
AB Skills development, the building of human capacity, is key to any sustainable capacity building effort, however, such undertakings require adaptable and tailored strategies. The Sickle Pan-African Research Consortium (SPARCo) is building capacity in sickle cell disease (SCD) management and research in sub-Saharan Africa, including a multi-national SCD patient registry, this is underpinned by skills development activities in data, research, and SCD management. Method: The SPARCo Skills Working Group was set up with the mandate of coordinating skills development activities across the three SPARCo sites in Ghana, Nigeria and Tanzania. To tailor activities to the requirements of the consortium, a needs assessment was conducted at the start of the project which identified skills required for SCD management and research and catalogued existing external and internal training programmes. The needs assessment highlighted differences in skill levels between the sites and different organisational structures which required tailored skills development activities at individual, site and consortium levels. Strategy: Based on the needs and the resources available, different types of training activities were implemented: these included online, blended and face to face activities. In order to create a sustainable skills development programme, existing short, medium, long-term, on-job training activities were used wherever possible. World Sickle Cell Day (19th June) was leveraged for training and health education activities. Results: SPARCo has recorded 1,726 participants in skills development activities across the three sites. Skills have been enhanced in data management, SCD and research to underpin the core deliverables of SPARCo. Conclusion and Lessons Learned: The baseline needs assessments and continual review and adjustment were critical for development of an effective skill development strategy for the consortium. This adaptability was particularly valuable during the COVID-19 pandemic. The sustainability plan leveraged existing programmes and activities and has created a pool of people with required skills for health care and research in SCD. To be effective, skills development programmes need to take into account existing capacity, training opportunities and local conditions. The model was applied to SCD and is adaptable to other skills development in healthcare and research in low and middle- income countries.
C1 [Nnodu, Obiageli Eunice] Univ Abuja, Abuja, Nigeria.
   [Nnodu, Obiageli Eunice] Univ Abuja, Ctr Excellence Sickle Cell Dis Res & Training, Abuja, Nigeria.
   [Nnodu, Obiageli Eunice] Univ Abuja, Coll Hlth Sci, Dept Haematol & Blood Transfus, Abuja, Nigeria.
   [Osei-Akoto, Alex] Komfo Anokye Teaching Hosp, Dept Child Hlth, Kumasi, Ghana.
   [Osei-Akoto, Alex] Kwame Nkrumah Univ Sci & Technol, Kumasi, Ghana.
   [Nembaware, Victoria; Wonkam, Ambroise] Univ Cape Town, Fac Hlth Sci, Div Human Genet, Cape Town, South Africa.
   [Nembaware, Victoria; Kent, Jill; Makani, Julie] Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania.
   [Nwegbu, Maxwell] Univ Abuja, Coll Hlth Sci, Dept Chem Pathol, Abuja, Nigeria.
   [Minja, Irene] Muhimbili Univ Hlth & Allied Sci, Dept Restorat Dent, Dar Es Salaam, Tanzania.
   [Mazandu, Gaston Kuzamunu] Stellenbosch Univ, African Inst Math Sci, Fac Sci, Muizenberg, South Africa.
   [Mazandu, Gaston Kuzamunu] African Inst Math Sci, Cape Town, South Africa.
   [Wonkam, Ambroise] Johns Hopkins Univ, Dept Genet Med, Sch Med, Baltimore, MD USA.
RP Nnodu, OE (通讯作者)，Univ Abuja, Abuja, Nigeria.; Nnodu, OE (通讯作者)，Univ Abuja, Ctr Excellence Sickle Cell Dis Res & Training, Abuja, Nigeria.; Nnodu, OE (通讯作者)，Univ Abuja, Coll Hlth Sci, Dept Haematol & Blood Transfus, Abuja, Nigeria.
EM oennodu@gmail.com
FU United States (United States) National Heart, Lung and Blood Institute
   (NHLBI) [U24HL13045881, U24HL135600]; Sickle Data Coordinating Center
FX Funding for this work was received from the United States (United
   States) National Heart, Lung and Blood Institute (NHLBI) (Grant Numbers
   U24HL13045881 the Sickle Pan African Research Consortium
   (04/01/2017-03/31/2021) and U24HL135600 and Sickle Data Coordinating
   Center, (04/01/2017-03/31/2021).
CR Adekile A, 2019, DATABASE-OXFORD, DOI 10.1093/database/baz118
   American Society of Hematology, 2021, CONS IN NEWB SCREEN
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NR 12
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-8021
J9 FRONT GENET
JI Front. Genet.
PD JUN 15
PY 2022
VL 13
AR 805806
DI 10.3389/fgene.2022.805806
PG 12
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA 2N5NV
UT WOS:000818426300001
PM 35783259
OA gold, Green Published
DA 2022-07-18
ER

PT J
AU Liu, MQ
   Cui, TT
   Wang, Q
   Han, Y
   Han, Y
   Yang, LQ
   Shi, NY
   Yi, YQ
   Jin, H
AF Liu, Minqi
   Cui, Tingting
   Wang, Qiang
   Han, Ying
   Han, Yue
   Yang, Liuqing
   Shi, Naiyang
   Yi, Youqin
   Jin, Hui
TI Using an extended protection motivation theory to explain vaccine
   hesitancy: a cross-sectional study among Chinese adults
SO HUMAN VACCINES & IMMUNOTHERAPEUTICS
LA English
DT Article
DE Vaccine hesitancy; protection motivation theory; behavior; adults
ID HEALTH-CARE WORKERS; FEAR APPEALS; METAANALYSIS; ACCEPTANCE; ATTITUDE;
   CANCER
AB Background Vaccine hesitancy was listed as one of the top 10 issues threatening global health in 2019. The objectives of this study were to (a) use an extended protection motivation theory (PMT) with an added trust component to identify predictors of vaccine hesitancy and (b) explore the predictive ability of vaccine hesitancy on vaccination behavior. Methods We conducted an online questionnaire from February 9 to April 9, 2021, in China. The target population was Chinese residents aged 18 and over. A total of 14,236 responses were received. Structural equation modeling was used to test the extended PMT model hypotheses. Results A total of 10,379 participants were finally included in this study, of whom 52.0% showed hesitancy toward vaccination. 2854 (27.5%) participants reported that they got flu shots in the past year, and 2561 (24.7%) participants were vaccinated against COVID-19. 2857 (27.5%) participants engaged in healthcare occupation. The model explained 85.7% variance of vaccine hesitancy. Self-efficacy was the strongest predictor, negatively associated with vaccine hesitancy (beta = -0.584; p < .001). Response efficacy had a negative effect on vaccine hesitancy (beta = -0.372; p < .001), while threat appraisal showed a positive effect (beta = 0.104; p < .001). Compared with non-health workers, health workers showed more vaccine hesitancy, and response efficacy was the strongest predictor (beta = -0.560; p < .001). Vaccine hesitancy had a negative effect on vaccination behavior (beta = -0.483; p < .001), and the model explained 23.4% variance of vaccination behavior. Conclusions This study demonstrates that the extended PMT model is efficient in explaining vaccine hesitancy. However, the predictive ability of vaccine hesitancy on vaccination behavior is limited.
C1 [Liu, Minqi; Cui, Tingting; Wang, Qiang; Han, Ying; Han, Yue; Yang, Liuqing; Shi, Naiyang; Yi, Youqin; Jin, Hui] Southeast Univ, Key Lab Environm Med Engn, Minist Educ, Sch Publ Hlth, Nanjing, Peoples R China.
   [Liu, Minqi; Cui, Tingting; Wang, Qiang; Han, Ying; Han, Yue; Yang, Liuqing; Shi, Naiyang; Yi, Youqin; Jin, Hui] Southeast Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Nanjing, Peoples R China.
RP Jin, H (通讯作者)，Southeast Univ, 87 Dingjiagiao, Nanjing 210009, Peoples R China.
EM jinhui_hld@163.com
FU Wuxi City Technology Development Fund [N20191007]; Postgraduate Research
   & Practice Innovation Program of Jiangsu Province [KYCX20_0153];
   Fundamental Research Funds for the Central Universities [3225002102D];
   Public Health Research Center of Jiangnan University [JUPH201845]
FX Supported by the Wuxi City Technology Development Fund (N20191007);
   Postgraduate Research & Practice Innovation Program of Jiangsu Province
   (KYCX20_0153); the Fundamental Research Funds for the Central
   Universities (3225002102D); Public Health Research Center of Jiangnan
   University (JUPH201845). The funder/sponsor did not partici-pate in the
   work.
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NR 45
TC 0
Z9 0
U1 24
U2 24
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 2164-5515
EI 2164-554X
J9 HUM VACC IMMUNOTHER
JI Human Vaccines Immunother.
PD DEC 31
PY 2022
VL 18
IS 1
DI 10.1080/21645515.2022.2026136
EA JAN 2022
PG 9
WC Biotechnology & Applied Microbiology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biotechnology & Applied Microbiology; Immunology
GA 0I3EP
UT WOS:000749358700001
PM 35103578
OA Green Published, hybrid
DA 2022-07-18
ER

PT J
AU Stamelou, M
   Struhal, W
   ten Cate, O
   Matczak, M
   Caliskan, SA
   Soffietti, R
   Marson, A
   Zis, P
   di Lorenzo, F
   Sander, A
   Deuschl, G
   de Visser, M
   Bassetti, CLA
AF Stamelou, Maria
   Struhal, Walter
   ten Cate, Olle
   Matczak, Magdalena
   Caliskan, Suleyman Ayhan
   Soffietti, Riccardo
   Marson, Anthony
   Zis, Panagiotis
   di Lorenzo, Francesco
   Sander, Anja
   Deuschl, Gunther
   de Visser, Marianne
   Bassetti, Claudio L. A.
TI Evaluation of the 2020 European Academy of Neurology virtual congress:
   transition from a face-to-face to a virtual meeting
SO EUROPEAN JOURNAL OF NEUROLOGY
LA English
DT Article
DE evaluation; international congress; quality; transition; virtual
   congress
AB Background and purpose Due to the COVID-19 pandemic, scientific congresses are increasingly being organized as virtual congresses (VCs). In May 2020, the European Academy of Neurology (EAN) held a VC, free of charge. In the absence of systematic studies on this topic, the aim of this study is to evaluate the attendance and perceived quality of the 2020 EAN VC compared to the 2019 EAN face-to-face congress (FFC).
   Methods An analysis of the demographic data of participants obtained from the online registration was done. A comparison of the two congresses based on a survey with questions on the perception of speakers' performance, quality of networking and other aspects was made.
   Results Of 43,596 registered participants, 20,694 active participants attended the VC. Compared to 2019, the number of participants tripled (6916 in 2019) and the cumulated number of participants attending the sessions was five times higher (169,334 in 2020 vs. 33,024 in 2019). Out of active participants 55% were from outside Europe, 42% were board-certified neurologists (FFC 80%) and 21% were students (FFC 0.6%). The content of the congress was evaluated as 'above expectation' by 56% of the attendees (FFC 41%). Of the respondents who had been exposed to earlier EAN congresses 73% preferred the FFC compared to the VC (17%).
   Conclusion The VC fulfilled the main mission of organizing high quality EAN congresses despite the restrictions of the impersonal format. The geographical distribution of the participants proves the expected higher inclusivity of a VC. The large participation of students and neurologists in training opens new educational potentials for the EAN.
C1 [Stamelou, Maria] HYGEIA Hosp, Parkinsons Dis & Movement Disorders Dept, Athens, Greece.
   [Stamelou, Maria] European Univ Cyprus, Nicosia, Cyprus.
   [Stamelou, Maria] Philipps Univ, Marburg, Germany.
   [Struhal, Walter] Karl Landsteiner Univ Hlth Sci, Univ Klinikum Tulln, Dept Neurol, Tulln, Austria.
   [ten Cate, Olle] Univ Med Ctr Utrecht, Ctr Res & Dev Educ, Utrecht, Netherlands.
   [Matczak, Magdalena; Sander, Anja] European Acad, Head Off, Vienna, Austria.
   [Caliskan, Suleyman Ayhan] Ege Univ, Dept Med Educ, Fac Med, Izmir, Turkey.
   [Soffietti, Riccardo] Univ & City Hlth & Sci, Dept Neurooncol, Turin, Italy.
   [Marson, Anthony] Univ Liverpool, Liverpool, Merseyside, England.
   [Marson, Anthony] Walton Ctr NHS Fdn Trust Liverpool, Liverpool, Merseyside, England.
   [Zis, Panagiotis] Univ Cyprus, Sch Med, Nicosia, Cyprus.
   [di Lorenzo, Francesco] Santa Lucia Fdn IRCCS, Dept Behav & Clin Neurol, Non Invas Brain Stimulat Unit, Rome, Italy.
   [Deuschl, Gunther] Univ Kiel, Univ Klinikum Schleswig Holstein, Dept Neurol, Kiel, Germany.
   [de Visser, Marianne] Univ Amsterdam, Dept Neurol, Med Ctr, Amsterdam, Netherlands.
   [Bassetti, Claudio L. A.] Univ Bern, Univ Hosp Bern, Inselspital, Dept Neurol, Freiburgstr, CH-3010 Bern, Switzerland.
RP Bassetti, CLA (通讯作者)，Univ Bern, Univ Hosp Bern, Inselspital, Dept Neurol, Freiburgstr, CH-3010 Bern, Switzerland.
EM claudio.bassetti@gmx.net
RI Çalışkan, Süleyman Ayhan/E-4465-2011; Soffietti, Riccardo/AAA-7965-2022;
   Çalışkan, S. Ayhan/AAC-2028-2020
OI Çalışkan, Süleyman Ayhan/0000-0001-9714-6249; Soffietti,
   Riccardo/0000-0002-9204-7038; Çalışkan, S. Ayhan/0000-0001-9714-6249;
   Zis, Panagiotis/0000-0001-8567-3092; Marson, Anthony/0000-0002-6861-8806
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   Terada A., 2018, EFFECTIVENESS VISUAL, P279
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   Viglione G, 2020, NATURE, V579, P327, DOI 10.1038/d41586-020-00786-y
NR 16
TC 2
Z9 3
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-5101
EI 1468-1331
J9 EUR J NEUROL
JI Eur. J. Neurol.
PD AUG
PY 2021
VL 28
IS 8
BP 2523
EP 2532
DI 10.1111/ene.14702
EA JUN 2021
PG 10
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA TM0RI
UT WOS:000660326000001
PM 33369806
OA Green Published, Bronze
DA 2022-07-18
ER

PT J
AU Gaiha, SM
   Lempert, LK
   McKelvey, K
   Halpern-Felsher, B
AF Gaiha, Shivani Mathur
   Lempert, Lauren Kass
   McKelvey, Karma
   Halpern-Felsher, Bonnie
TI E-cigarette devices, brands, and flavors attract youth: Informing FDA's
   policies and priorities to close critical gaps
SO ADDICTIVE BEHAVIORS
LA English
DT Article
DE E-cigarettes; Adolescents; Young adults; Pod/cartridge; Disposable;
   Flavor Flavor-enhancer; Brand; Regulation; Restriction; FDA
ID ELECTRONIC CIGARETTES; ADOLESCENTS; TOBACCO; ASSOCIATION; SMOKING
AB Purpose: Identify e-cigarette devices, brands, and flavor types used by adolescents and young adults soon after the enactment of flavor restrictions, youth access laws, FDA's enforcement prioritization against some flavored pod/cartridge-based e-cigarettes, and during COVID-19 pandemic-related school closures.
   Methods: National cross-sectional online survey (N = 4,351) in May 2020 assessed popularity, ever- and past-30-day use of e-cigarette device types (pod/cartridge-based, disposables, others), brands, flavor types and flavorenhancers, by age group (under age 21 and 21 and over).
   Results: While pod/cartridge-based e-cigarettes had the highest ever-use (82.7% <21; 69.8% >= 21) and were most often-used (41.9% <21; 41.4% >= 21), most past 30-day-users (50.8% <21; 61.9% >= 21) and 7-day-users (36.0% <21; 56.7% >= 21) used disposables. Mint/menthol was the most-used flavor type (pod/cartridge-based: 48.2% <21, 48.1% >= 21; disposables: 51.6% <21, 56.4% >= 21), followed by fruit (pod/cartridge-based: 37.4% <21, 35.5%>= 21; disposables: 51.6% >21, 46.2% >= 21), and sweet/dessert/candy flavor types (pod/cartridge-based: 24.4% <21, 24.7% >= 21; disposables: 29.7% <21, 33.8% >= 21). Participants reported using add-on e-cigarette flavor-enhancers (pod/cartridge-based: 24.6%; disposables: 31.3%).
   Conclusion: Soon after FDA's January 2020 announcement of prioritized enforcement against flavored pod/cartridge-based e-cigarettes and during the pandemic lockdown, adolescents' and young adults' past 30-day use included mostly flavored disposables rather than pod/cartridge-based e-cigarettes, mint/menthol flavors, and some used add-on flavor enhancers. To reduce youth use, comprehensive regulation of e-cigarette devices and flavors should be enacted and enforced at federal, state, and local levels.
C1 [Gaiha, Shivani Mathur; Lempert, Lauren Kass; McKelvey, Karma; Halpern-Felsher, Bonnie] Stanford Univ, Dept Pediat, Div Adolescent Med, 3145 Porter Dr,Wing A,Room A104, Palo Alto, CA 94304 USA.
   [Lempert, Lauren Kass] Univ Calif San Francisco, Ctr Tobacco Control Res & Educ, San Francisco, CA 94143 USA.
RP Halpern-Felsher, B (通讯作者)，Stanford Univ, Dept Pediat, Div Adolescent Med, 3145 Porter Dr,Wing A,Room A104, Palo Alto, CA 94304 USA.
EM bonnie.halpernfelsher@stanford.edu
OI Halpern-Felsher, Bonnie/0000-0001-9276-1322; McKelvey,
   Karma/0000-0003-4047-3120; Gaiha, Shivani/0000-0002-0636-8936
FU Taube Research Faculty Scholar Endowment [U54 HL147127]; National Heart,
   Lung, and Blood Institute; Food and Drug Administration Center for
   Tobacco Products
FX The research reported in this article was supported by the Taube
   Research Faculty Scholar Endowment to Dr. Halpern-Felsher. Additional
   support was received from grant U54 HL147127 from the National Heart,
   Lung, and Blood Institute and the Food and Drug Administration Center
   for Tobacco Products.
NR 0
TC 2
Z9 2
U1 2
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4603
EI 1873-6327
J9 ADDICT BEHAV
JI Addict. Behav.
PD MAR
PY 2022
VL 126
AR 107179
DI 10.1016/j.addbeh.2021.107179
PG 9
WC Psychology, Clinical; Substance Abuse
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Substance Abuse
GA 2T6CY
UT WOS:000822561500010
PM 34861522
DA 2022-07-18
ER

PT J
AU Touray, MML
   Cohen, DR
   Williams, SRP
   Alam, MF
   Groves, S
   Longo, M
   Gage, H
AF Touray, Morro M. L.
   Cohen, David R.
   Williams, Simon Robert Pask
   Alam, Mohammed Fasihul
   Groves, Sam
   Longo, Mirella
   Gage, Heather
TI Overweight/Obesity and Time Preference: Evidence from a Survey among
   Adults in the UK
SO OBESITY FACTS
LA English
DT Article
DE Overweight; Obesity; Time preference; Behavioural economics; Economics
   of obesity; Physical activities; Intertemporal choice
ID BODY-MASS INDEX; OBESITY; HEALTH; DEMOGRAPHICS
AB Introduction: Overweight and obesity is a global problem incurring substantial health and economic implications. This has also been highlighted by the ongoing COVID-19 pandemic which has disproportionately affected overweight and obese individuals. Most of the interventions have concentrated on promotion of physical activities and healthy eating which may involve current sacrifices for future health gains. The purpose of this study was to explore the relationship between bodyweight and how individuals state they would trade-off immediate income for higher amounts in the future (time preference). Methods: An online survey was conducted targeting adults aged >16 years in the UK (England, Northern Ireland, Scotland, and Wales) from January 1, 2016 to July 31, 2016. Using paid online adverts, as well as personal and professional networks for distribution of links to the online survey, the questionnaire asked respondents to report socio-economic and demographic information, height, and weight and to complete a time preference exercise. Data were analysed using descriptive statistics; associations were explored between BMI and respondents' characteristics and time preference using Spearman rank-order correlation and chi(2) tests as appropriate. We adopted STROBE guidelines for the reporting of the study. Results: A total of 561 responses were analysed (female = 293, males = 268). The relationship between time preference and overweight/obesity, using BMI as the measure is highly significant (chi(2) = 95.92: p < 0.001). Individuals of normal weight have low time preferences and are more likely to invest in activities in a bid to reap future health benefits. There are also significant relationships between BMI and employment status (chi(2) = 37.03; p < 0.001), physical activities (p < 0.0001), income levels (chi(2) = 6.68; p < 0.035), family orientation, i.e., with or without children (chi(2) = 12.88; p < 0.012), and ethnicity (chi(2) = 18.31; p < 0.001). These imply that individuals in employment and with children in their families are less likely to be overweight or obese compared to those who do not. People from black backgrounds are also more likely to be overweight or obese and have higher time preferences compared to people from white backgrounds. Discussions/Conclusions: People's preventive behaviours today can be predicted by their time preference and this understanding could be vital in improving population's uptake and maintenance of overweight and obesity prevention actions. People who have low time preference are more likely to invest time and resources in physical activities and healthy lifestyles to reap future health benefits hence value utilities-in-anticipation. Public health programmes should therefore use the knowledge of the association between time preference and overweight/obesity to inform designs of intervention programmes.
C1 [Touray, Morro M. L.; Gage, Heather] Univ Surrey, Fac Hlth & Med Sci, Surrey Hlth Econ Ctr, Guildford, Surrey, England.
   [Touray, Morro M. L.; Cohen, David R.] Univ South Wales, Fac Life Sci & Educ, Sch Care Sci, Pontypridd, M Glam, Wales.
   [Williams, Simon Robert Pask] Univ Wales Trinity St David, Inst Management & Hlth, Carmarthen, Dyfed, Wales.
   [Williams, Simon Robert Pask] Aneurin Bevan Univ Hlth Board, St Cadocs Hosp, Weight Management Serv, Caerleon, Wales.
   [Alam, Mohammed Fasihul] Qatar Univ, Coll Hlth Sci, Dept Publ Hlth, QU Hlth, Doha, Qatar.
   [Groves, Sam] Swansea Univ, Swansea Ctr Hlth Econ, Swansea, Wales.
   [Longo, Mirella; Gage, Heather] Cardiff Univ, Marie Curie Palliat Care Res Ctr, Sch Med, Cardiff, S Glam, Wales.
RP Touray, MML (通讯作者)，Univ Surrey, Fac Hlth & Med Sci, Surrey Hlth Econ Ctr, Guildford, Surrey, England.; Touray, MML (通讯作者)，Univ South Wales, Fac Life Sci & Educ, Sch Care Sci, Pontypridd, M Glam, Wales.
EM m.touray@surrey.ac.uk
OI Williams, Simon/0000-0002-7442-7395
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NR 41
TC 0
Z9 0
U1 0
U2 0
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1662-4025
EI 1662-4033
J9 OBESITY FACTS
JI Obes. Facts
PD MAY
PY 2022
VL 15
IS 3
BP 428
EP 441
DI 10.1159/000522651
PG 14
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 1M3DP
UT WOS:000799853300013
PM 35203081
OA Green Published, Green Accepted, gold
DA 2022-07-18
ER

PT J
AU Read, J
   Renton, J
   Harrop, C
   Geekie, J
   Dowrick, C
AF Read, John
   Renton, Julia
   Harrop, Christopher
   Geekie, Jim
   Dowrick, Christopher
TI A survey of UK general practitioners about depression, antidepressants
   and withdrawal: implementing the 2019 Public Health England report
SO THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY
LA English
DT Article
DE Antidepressants; Withdrawal; General Practitioners; Primary Care;
   Depression; Training
ID BELIEFS; PLACEBO; PEOPLE; METAANALYSIS
AB Background: In 2019, a literature review indicated that more than half of people who try to come off antidepressants experience withdrawal effects. Both the National Institute of Health and Care Excellence and the Royal College of Psychiatrists updated their positions in line with that review, and Public Health England published a 152-page report calledDependence and withdrawal associated with some prescribed medicines: an evidence review. The report made several recommendations relevant to general practice.
   Method: In order to facilitate implementation of these recommendations, an online survey was designed to explore United Kingdom general practitioner (GP) experiences, opinions, knowledge and needs in relation to depression, ADs and withdrawal. A total of 66 GPs had completed the survey when COVID-19 occurred.
   Results: In keeping with previous findings, this small sample of GPs had a predominantly psycho-social perspective on the causes of, and treatments for, depression. They broadly considered ADs effective for moderate/severe depression and ineffective for minimal/mild depression, for which they preferred psychological therapies and social prescribing. There was a marked lack of consistency in GPs' knowledge about the incidence and duration of withdrawal effects. Only a minority (29%) felt their knowledge about withdrawal was 'adequate' and fewer (17%) believed this about their 'Ability to distinguish between withdrawal effects and return of the original problem (e.g. depression)'. Two-thirds (68%) would like more training on these matters.
   Conclusion: It is hoped that even this small sample will be helpful when designing, and seeking funding for, GP training programmes, and when implementing the PHE recommendations for support services, based in the primary care system, for the millions of people contemplating or initiating withdrawal from ADs every year in the UK.
C1 [Read, John] Univ East London, Sch Psychol, Water Lane, London E15 4LZ, England.
   [Renton, Julia; Harrop, Christopher] West London NHS Trust, London, England.
   [Geekie, Jim] NHS Educ Scotland, Edinburgh, Midlothian, Scotland.
   [Geekie, Jim] NHS Lothian, Edinburgh, Midlothian, Scotland.
   [Dowrick, Christopher] Univ Liverpool, Primary Med Care, Liverpool, Merseyside, England.
   [Dowrick, Christopher] Aintree Pk Grp Practice, Liverpool, Merseyside, England.
RP Read, J (通讯作者)，Univ East London, Sch Psychol, Water Lane, London E15 4LZ, England.
EM john@uel.ac.uk
OI Harrop, Chris/0000-0002-0644-8127
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NR 47
TC 7
Z9 7
U1 0
U2 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 2045-1253
EI 2045-1261
J9 THER ADV PSYCHOPHARM
JI Ther. Adv. Psychopharm.
PD AUG
PY 2020
VL 10
AR 2045125320950124
DI 10.1177/2045125320950124
PG 14
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Psychiatry
GA NJ9QK
UT WOS:000566378100001
PM 32922735
OA Green Published, gold
DA 2022-07-18
ER

PT J
AU Zuvanov, L
   Garcia, ALB
   Correr, FH
   Bizarria, R
   da Costa, AP
   da Costa, AH
   Thomaz, AT
   Pinheiro, ALM
   Riano-Pachon, DM
   Winck, FV
   Esteves, FG
   Margarido, GRA
   Casagrande, GMS
   Frajacomo, HC
   Martins, L
   Cavalheiro, MF
   Grachet, NG
   da Silva, RGC
   Cerri, R
   Ramos, RTJ
   de Medeiros, SDS
   Tavares, TV
   dos Santos, RAC
AF Zuvanov, Luiza
   Basso Garcia, Ana Letycia
   Correr, Fernando Henrique
   Bizarria Jr, Rodolfo
   da Costa Filho, Ailton Pereira
   da Costa, Alisson Hayasi
   Thomaz, Andrea T.
   Mendes Pinheiro, Ana Lucia
   Riano-Pachon, Diego Mauricio
   Winck, Flavia Vischi
   Esteves, Franciele Grego
   Alves Margarido, Gabriel Rodrigues
   Stanfoca Casagrande, Giovanna Maria
   Frajacomo, Henrique Cordeiro
   Martins, Leonardo
   Cavalheiro, Mariana Feitosa
   Grachet, Nathalia Graf
   Costa da Silva, Raniere Gaia
   Cerri, Ricardo
   Juca Ramos, Rommel Thiago
   Sartorio de Medeiros, Simone Daniela
   Tavares, Thayana Vieira
   Correa dos Santos, Renato Augusto
TI The experience of teaching introductory programming skills to
   bioscientists in Brazil
SO PLOS COMPUTATIONAL BIOLOGY
LA English
DT Article
AB Computational biology has gained traction as an independent scientific discipline over the last years in South America. However, there is still a growing need for bioscientists, from different backgrounds, with different levels, to acquire programming skills, which could reduce the time from data to insights and bridge communication between life scientists and computer scientists. Python is a programming language extensively used in bioinformatics and data science, which is particularly suitable for beginners. Here, we describe the conception, organization, and implementation of the Brazilian Python Workshop for Biological Data. This workshop has been organized by graduate and undergraduate students and supported, mostly in administrative matters, by experienced faculty members since 2017. The workshop was conceived for teaching bioscientists, mainly students in Brazil, on how to program in a biological context. The goal of this article was to share our experience with the 2020 edition of the workshop in its virtual format due to the Coronavirus Disease 2019 (COVID-19) pandemic and to compare and contrast this year's experience with the previous in-person editions. We described a hands-on and live coding workshop model for teaching introductory Python programming. We also highlighted the adaptations made from in-person to online format in 2020, the participants' assessment of learning progression, and general workshop management. Lastly, we provided a summary and reflections from our personal experiences from the workshops of the last 4 years. Our takeaways included the benefits of the learning from learners' feedback (LLF) that allowed us to improve the workshop in real time, in the short, and likely in the long term. We concluded that the Brazilian Python Workshop for Biological Data is a highly effective workshop model for teaching a programming language that allows bioscientists to go beyond an initial exploration of programming skills for data analysis in the medium to long term.
C1 [Zuvanov, Luiza] Univ Sao Paulo, Sao Carlos Inst Phys, Sao Carlos, Brazil.
   [Basso Garcia, Ana Letycia; Correr, Fernando Henrique; Mendes Pinheiro, Ana Lucia; Alves Margarido, Gabriel Rodrigues] Univ Sao Paulo, Luiz de Queiroz Coll Agr, Dept Genet, Piracicaba, Brazil.
   [Bizarria Jr, Rodolfo] Sao Paulo State Univ, Dept Gen & Appl Biol, Rio Claro, Brazil.
   [Bizarria Jr, Rodolfo; Esteves, Franciele Grego] Sao Paulo State Univ, Ctr Study Social Insects, Inst Biosci Rio Claro, Dept Gen & Appl Biol, Rio Claro, Brazil.
   [da Costa Filho, Ailton Pereira] Univ Sao Paulo, Ribeirao Preto Med Sch, Ribeirao Preto, Brazil.
   [da Costa, Alisson Hayasi; Frajacomo, Henrique Cordeiro; Cerri, Ricardo] Univ Fed Sao Carlos, Dept Comp Sci, Sao Carlos, Brazil.
   [Thomaz, Andrea T.] Univ Rosario, Sch Nat Sci, Bogota, Colombia.
   [Riano-Pachon, Diego Mauricio] Univ Sao Paulo, Ctr Nucl Energy Agr, Computat Evolutionary & Syst Biol Lab, Piracicaba, Brazil.
   [Winck, Flavia Vischi] Univ Sao Paulo, Ctr Nucl Energy Agr, Regulatory Syst Biol Lab, Piracicaba, Brazil.
   [Stanfoca Casagrande, Giovanna Maria] Barretos Canc Hosp, Barretos, Brazil.
   [Martins, Leonardo] Univ Fed Sao Paulo, Paulista Sch Med, Sao Paulo, Brazil.
   [Cavalheiro, Mariana Feitosa] Univ Estadual Campinas, Inst Biol, Dept Genet Evolut Microbiol & Immunol, Campinas, Brazil.
   [Cavalheiro, Mariana Feitosa] Univ Estadual Campinas, Genom Climate Change Res Ctr, Campinas, Brazil.
   [Grachet, Nathalia Graf] Roche Sequencing Solut, Pleasanton, CA USA.
   [Costa da Silva, Raniere Gaia] City Univ Hong Kong, Jockey Club Coll Vet Med & Life Sci, Dept Infect Dis & Publ Hlth, Hong Kong, Peoples R China.
   [Juca Ramos, Rommel Thiago] Fed Univ Para, Inst Biol Sci, Belem, Para, Brazil.
   [Sartorio de Medeiros, Simone Daniela] Univ Fed Santa Catarina, Dept Informat & Stat, Florianopolis, SC, Brazil.
   [Tavares, Thayana Vieira] Univ Fed Sao Carlos, Dept Genet & Evolut, Sao Carlos, Brazil.
   [Correa dos Santos, Renato Augusto] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Ribeirao Preto, Brazil.
   [Correa dos Santos, Renato Augusto] Univ Estadual Campinas, Inst Biol, Campinas, Brazil.
RP dos Santos, RAC (通讯作者)，Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Ribeirao Preto, Brazil.; dos Santos, RAC (通讯作者)，Univ Estadual Campinas, Inst Biol, Campinas, Brazil.
EM renatoacsantos@gmail.com
RI Riaño-Pachón, Diego Mauricio/B-4891-2014; Martins, Leonardo/N-9454-2013;
   dos Santos, Renato Augusto Corrêa/A-7065-2016; Ramos, Rommel Thiago
   Juca/L-9329-2013
OI Riaño-Pachón, Diego Mauricio/0000-0001-9803-3465; Martins,
   Leonardo/0000-0003-3524-4876; dos Santos, Renato Augusto
   Corrêa/0000-0003-0826-5479; Ramos, Rommel Thiago
   Juca/0000-0002-8032-1474; Basso Garcia, Ana Letycia/0000-0003-1497-2567;
   Correr, Fernando Henrique/0000-0001-8562-1946; Zuvanov,
   Luiza/0000-0003-0132-4894; Silva, Raniere/0000-0002-8381-3749; Bizarria
   Junior, Rodolfo/0000-0003-4293-5886; Costa Filho,
   Ailton/0000-0002-5200-9774
FU Sao Paulo Research Foundation (FAPESP); Coordination for the Improvement
   of Higher Education Personnel (CAPES); Brazilian National Council for
   Scientific and Technological Development (CNPq); FAPESP [2019/10727-1,
   2017/10373-0, 2020/04437-8, 2015/03541-8, 2020/029829, 2020/02084-0,
   2019/24412-2, 2017/21983-3, 2019/07526-4]; CNPq [142583/2018-9,
   132737/2019-1, 140585/2018-4, 131314/2018-1, 140481/2020-6]; CAPES
   [88887.529609/2020-00]
FX Authors thank foundations that made this publication possible by funding
   authors' own research projects over the period overlapping the
   organization of at least one of the workshops: Sao Paulo Research
   Foundation (FAPESP), Coordination for the Improvement of Higher
   Education Personnel (CAPES), and the Brazilian National Council for
   Scientific and Technological Development (CNPq). APCF, FGE, GMSC, LM,
   LZ, MFC, RBJ, and RACdS hold FAPESP scholarships (process numbers:
   2019/10727-1, 2017/10373-0, 2020/04437-8, 2015/03541-8,
   2020/029829,2020/02084-0, 2019/24412-2, 2017/21983-3, and 2019/07526-4).
   ALBG, ALMP, FHC, LZ, and MFC hold CNPq scholarships (process numbers:
   142583/2018-9, 132737/2019-1, 140585/2018-4, 131314/2018-1, and
   140481/2020-6, respectively). LZ holds a CAPES scholarship (process
   number: 88887.529609/2020-00). The funders had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 13
TC 1
Z9 1
U1 3
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-734X
EI 1553-7358
J9 PLOS COMPUT BIOL
JI PLoS Comput. Biol.
PD NOV
PY 2021
VL 17
IS 11
AR e1009534
DI 10.1371/journal.pcbi.1009534
PG 16
WC Biochemical Research Methods; Mathematical & Computational Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Mathematical & Computational Biology
GA YS5PD
UT WOS:000750727700007
PM 34762646
OA Green Published, gold
DA 2022-07-18
ER

PT J
AU Naomi, R
   Yazid, MD
   Bahari, H
   Keong, YY
   Rajandram, R
   Embong, H
   Teoh, SH
   Halim, S
   Othman, F
AF Naomi, Ruth
   Yazid, Muhammad Dain
   Bahari, Hasnah
   Keong, Yong Yoke
   Rajandram, Retnagowri
   Embong, Hashim
   Teoh, Soo Huat
   Halim, Shariff
   Othman, Fezah
TI Bisphenol A (BPA) Leading to Obesity and Cardiovascular Complications: A
   Compilation of Current In Vivo Study
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE endocrine disruptors; obesity; neuroimmune signals; cardiovascular
   complications; transgenerational effects; biomarkers
ID NEUROPEPTIDE-Y; INSULIN-RESISTANCE; PROVIDE GUIDELINES;
   LIPID-METABOLISM; DNA METHYLATION; ADIPOSE-TISSUES; FOOD-INTAKE;
   EXPOSURE; RECEPTOR; ASSOCIATION
AB BPA is one of the most common endocrine disruptors that is widely being manufactured daily nationwide. Although scientific evidence supports claims of negative effects of BPA on humans, there is also evidence suggesting that a low level of BPA is safe. However, numerous in vivo trials contraindicate with this claim and there is a high possibility of BPA exposure could lead to obesity. It has been speculated that this does not stop with the exposed subjects only, but may also cause transgenerational effects. Direct disruption of endocrine regulation, neuroimmune and signaling pathways, as well as gut microbiata, has been identified to be interrupted by BPA exposure, leading to overweight or obesity. In these instances, cardiovascular complications are one of the primary notable clinical signs. In regard to this claim, this review paper discusses the role of BPA on obesity in the perspective of endocrine disruptions and possible cardiovascular complications that may arise due to BPA. Thus, the aim of this review is to outline the changes in gut microbiota and neuroimmune or signaling mechanisms involved in obesity in relation to BPA. To identify potentially relevant articles, a depth search was done on the databases Nature, PubMed, Wiley Online Library, and Medline & Ovid from the past 5 years. According to Boolean operator guideline, selected keywords such as (1) BPA OR environmental chemical AND fat OR LDL OR obese AND transgenerational effects or phenocopy (2) Endocrine disruptors OR chemical AND lipodystrophy AND phenocopy (3) Lipid profile OR weight changes AND cardiovascular effect (4) BPA AND neuroimmune OR gene signaling, were used as search terms. Upon screening, 11 articles were finalized to be further reviewed and data extraction tables containing information on (1) the type of animal model (2) duration and dosage of BPA exposure (3) changes in the lipid profile or weight (4) genes, signaling mechanism, or any neuroimmune signal involved, and (5) transgenerational effects were created. In toto, the study indicates there are high chances of BPA exposure affecting lipid profile and gene associated with lipolysis, leading to obesity. Therefore, this scoping review recapitulates the possible effects of BPA that may lead to obesity with the evidence of current in vivo trials. The biomarkers, safety concerns, recommended dosage, and the impact of COVID-19 on BPA are also briefly described.
C1 [Naomi, Ruth; Bahari, Hasnah; Keong, Yong Yoke] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Human Anat, Serdang 43400, Malaysia.
   [Yazid, Muhammad Dain] Univ Kebangsaan Malaysia, Fac Med, Ctr Tissue Engn & Regenerat Med, Kuala Lumpur 56000, Malaysia.
   [Rajandram, Retnagowri] Univ Malaya, Fac Med, Dept Surg, Kuala Lumpur 50603, Malaysia.
   [Embong, Hashim] Univ Kebangsaan Malaysia, Fac Med, Dept Emergency Med, Kuala Lumpur 56000, Malaysia.
   [Teoh, Soo Huat] Univ Sains Malaysia, Adv Med & Dent Inst, George Town 13200, Malaysia.
   [Halim, Shariff] Management & Sci Univ, Int Med Sch, Off Persiaran Olahraga, Neurosci Res Grp, Univ Dr, Shah Alam 40100, Selangor, Malaysia.
   [Othman, Fezah] Univ Putra Malaysia UPM, Fac Med & Hlth Sci, Dept Biomed Sci, Serdang 43400, Malaysia.
RP Othman, F (通讯作者)，Univ Putra Malaysia UPM, Fac Med & Hlth Sci, Dept Biomed Sci, Serdang 43400, Malaysia.
EM ruthmanue12104@gmail.com; dain@ukm.edu.my; haba@upm.edu.my;
   yoke_keong@upm.edu.my; retnagowri@ummc.edu.my;
   hashimembong77@ukm.edu.my; soohuat@usm.my; drhalim_shariff@msu.edu.my;
   fezah@upm.edu.my
RI Teoh, Soo Huat/R-7736-2018; Rajandram, Retnagowri/E-1245-2012; Naomi,
   Ruth/AAF-9536-2021
OI Teoh, Soo Huat/0000-0002-5735-6441; Rajandram,
   Retnagowri/0000-0001-5247-2817; Naomi, Ruth/0000-0002-7937-1255; Embong,
   Hashim/0000-0002-0536-2145; Halim, Shariff/0000-0003-3792-9879; Bahari,
   Hasnah/0000-0001-8302-4136; Othman, Fezah/0000-0002-0924-6264; Yong,
   Yoke Keong/0000-0002-9442-7456; Yazid, Muhammad Dain/0000-0001-6162-4405
FU Long Term Research Grant Scheme-Malaysia Research University Network
   [630018-14001]; Ministry of Higher Education
FX This research was funded by Long Term Research Grant Scheme-Malaysia
   Research University Network (Grant No. 630018-14001) under Ministry of
   Higher Education.
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NR 142
TC 1
Z9 1
U1 19
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2022
VL 23
IS 6
AR 2969
DI 10.3390/ijms23062969
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 0C5NI
UT WOS:000775359300001
PM 35328389
OA gold, Green Published
DA 2022-07-18
ER

PT J
AU Abdulmannan, DM
   Naser, AY
   Ibrahim, OK
   Mahmood, AS
   Alkrad, JA
   Sweiss, K
   Alrawashdeh, HM
   Kautsar, AP
AF Abdulmannan, Dina M.
   Naser, Abdallah Y.
   Ibrahim, Omar Khaleel
   Mahmood, Abdullah Shakir
   Alkrad, Jamal Alyoussef
   Sweiss, Kanar
   Alrawashdeh, Hamzeh Mohammad
   Kautsar, Angga Prawira
TI Visual health and prevalence of dry eye syndrome among university
   students in Iraq and Jordan
SO BMC OPHTHALMOLOGY
LA English
DT Article
DE Dry eye syndrome; Iraq; Jordan; Students; Visual health
ID WORK PRODUCTIVITY; DISEASE; SYMPTOMS
AB Dry eye syndrome (DES), is a multifactorial disease that affects the ocular surface and contributes to the ocular symptoms. The COVID-19 pandemic influenced the general population and university students' health in different ways. The pandemic forced many people including university students around the world to use virtual platforms on their digital devices, such as computers and smartphones, to work from a distance. This study aimed to explore the visual health and prevalence of dry eye syndrome among university students in Iraq and Jordan. This was a cross-sectional study that was conducted in Iraq and Jordan using online questionnaire tool for the duration between November 2021 and January 2022. University students in Jordan and Iraq were invited to participate in this study and formed the study population. No restrictions on study level or field of study were applied. A previously developed and validated questionnaire tools were used in this study (National Eye Institute Visual Functioning Questionnaire - 25 (VFQ-25) and the Women's Health Study Questionnaire (WHS), which was developed by Schaumberg et al.). A total of 1,431 university students were involved in this study (1,018 students from Iraq, 71.1%). Around one third the study participants (29.0%) reported that have been diagnosed by a clinician as having dry eye syndrome. Around15.3% of the total study participants reported that they feel their eyes are dry (not wet enough) and 17.3% reported that they feel their eyes are irritated. Based on Women's Health Study Questionnaire (WHS) criteria, a total of 479 participants (33.4%) are symptomatically diagnosed with DES. Students aged 27-29 years, those at their fifth year of study, and those who wear contact lenses are at higher risk of developing DYS compared to others. Dry eye syndrome is common health problem among university students. Further studies are required to identify other risk factors associated with DES. Future research should focus on identifying strategies that could help reduce the risk of developing DES as a result of the inevitability of long-term use of digital devices among many categories of society, including university students.
C1 [Abdulmannan, Dina M.] Umm Alqura Univ, Coll Med, Mecca, Saudi Arabia.
   [Naser, Abdallah Y.; Ibrahim, Omar Khaleel; Alkrad, Jamal Alyoussef] Isra Univ, Fac Pharm, Dept Appl Pharmaceut Sci & Clin Pharm, Amman, Jordan.
   [Mahmood, Abdullah Shakir] Ninevah Univ, Coll Med, Mosul, Iraq.
   [Sweiss, Kanar] Isra Univ, Fac Pharm, Dept Basic Pharmaceut Sci, Amman, Jordan.
   [Alrawashdeh, Hamzeh Mohammad] Sharif Eye Ctr, Dept Ophthalmol, Irbid, Jordan.
   [Kautsar, Angga Prawira] Univ Groningen, Dept Hlth Sci, Unit Global Hlth, Univ Med Ctr Groningen, Groningen, Netherlands.
   [Kautsar, Angga Prawira] Univ Padjadjaran, Fac Pharm, Dept Pharmaceut & Pharmaceut Technol, Bandung, West Java, Indonesia.
   [Kautsar, Angga Prawira] Univ Padjadjaran, Ctr Excellence Higher Educ Pharmaceut Care Innova, Bandung, West Java, Indonesia.
RP Naser, AY (通讯作者)，Isra Univ, Fac Pharm, Dept Appl Pharmaceut Sci & Clin Pharm, Amman, Jordan.
EM abdallah.naser@iu.edu.jo
RI kautsar, angga/O-2344-2018
OI kautsar, angga/0000-0001-6868-5286
FU Isra University, Amman, Jordan
FX L This study was supported by Isra University, Amman, Jordan.
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NR 36
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2415
J9 BMC OPHTHALMOL
JI BMC Ophthalmol.
PD JUN 14
PY 2022
VL 22
IS 1
AR 265
DI 10.1186/s12886-022-02485-w
PG 16
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA 2C1XL
UT WOS:000810669400001
PM 35698109
OA Green Published, gold
DA 2022-07-18
ER

PT J
AU Altamirano, J
   Lopez, M
   Robinson, IG
   Chun, LX
   Tam, GKY
   Shaikh, NJ
   Hoyte, EG
   Carrington, YJ
   Jani, SG
   Toomarian, EY
   Hsing, JC
   Ma, J
   Pulendran, U
   Govindarajan, P
   Blomkalns, AL
   Pinsky, BA
   Wang, CJ
   Maldonado, Y
AF Altamirano, Jonathan
   Lopez, Marcela
   Robinson, India G.
   Chun, Leanne X.
   Tam, Grace K-Y
   Shaikh, Nuzhat J.
   Hoyte, Elisabeth G.
   Carrington, Yuan Jin
   Jani, Shilpa G.
   Toomarian, Elizabeth Y.
   Hsing, Julianna C.
   Ma, Jasmin
   Pulendran, Uma
   Govindarajan, Prasanthi
   Blomkalns, Andra L.
   Pinsky, Benjamin A.
   Wang, C. Jason
   Maldonado, Yvonne
TI Feasibility of Specimen Self-collection in Young Children Undergoing
   SARS-CoV-2 Surveillance for In-Person Learning
SO JAMA NETWORK OPEN
LA English
DT Article
AB IMPORTANCE There is an urgent need to assess the feasibility of COVID-19 surveillance measures in educational settings.
   OBJECTIVE To assess whether young children can feasibly self-collect SARS-CoV-2 samples for surveillance testing over the course of an academic year.
   DESIGN, SETTING, AND PARTICIPANTS This prospective pilot cohort study was conducted from September 10, 2020, to June 10, 2021, at a K-8 school in San Mateo County, California. The research consisted of quantitative data collection efforts: (1) demographic data collected, (2) student sample self-collection error rates, and (3) student sample self-collection time durations. Students were enrolled in a hybrid learning model, a teaching model in which students were taught in person and online, with students having the option to attend virtually as needed. Data were collected under waiver of consent from students participating in weekly SARS-CoV-2 testing.
   MAIN OUTCOMES AND MEASURES Errors over time for self-collection of nasal swabs such as contaminated swabs and inadequate or shallow swabbing; time taken for sample collection.
   RESULTS Of 296 participants, 148 (50.0%) were boys and 148 (50.0%) were girls. A total of 87 participants (29.2%) identified as Asian; 2 (0.6%), Black or African American; 13 (4.4%), Hispanic/Latinx; 103 (34.6%). non-Hispanic White; 87 (29.2%), multiracial; and 6 (2.0%). other. The median school grade was fourth grade. From September 2020 to March 2021, a total of 4203 samples were obtained from 221 students on a weekly basis, while data on error rates were collected. Errors occurred in 2.7% (n = 107; 95% CI, 2.2%-3.2%) of student encounters, with the highest rate occurring on the first day of testing (20 [10.2%]). There was an overall decrease in error rates over time. From April to June 2021, a total of 2021 samples were obtained from 296 students on a weekly basis while data on encounter lengths were collected. Between April and June 2021, 193 encounters were timed. The mean duration of each encounter was 70 seconds (95% CI, 66.4-73.7 seconds).
   CONCLUSIONS AND RELEVANCE Mastery of self-collected lower nasal swabs is possible for children 5 years and older. Testing duration can be condensed once students gain proficiency in testing procedures. Scalability for larger schools is possible if consideration is given to the resource-intensive nature of the testing and the setting's weather patterns.
C1 [Altamirano, Jonathan; Lopez, Marcela; Robinson, India G.; Chun, Leanne X.; Tam, Grace K-Y; Shaikh, Nuzhat J.; Carrington, Yuan Jin; Maldonado, Yvonne] Stanford Univ, Dept Pediat, Div Infect Dis, Sch Med, Stanford, CA 94305 USA.
   [Altamirano, Jonathan; Hsing, Julianna C.; Maldonado, Yvonne] Stanford Univ, Sch Med, Dept Epidemiol & Populat Hlth, Stanford, CA 94305 USA.
   [Hoyte, Elisabeth G.] Stanford Univ, Dept Pediat, Sch Med, Div Allergy Immunol & Rheumatol, Stanford, CA 94305 USA.
   [Jani, Shilpa G.; Hsing, Julianna C.; Ma, Jasmin; Pulendran, Uma; Wang, C. Jason] Stanford Univ, Sch Med, Dept Pediat, Ctr Policy Outcomes & Prevent, Stanford, CA 94305 USA.
   [Toomarian, Elizabeth Y.] Stanford Univ, Grad Sch Educ, Stanford, CA 94305 USA.
   [Toomarian, Elizabeth Y.] Synapse Sch, Menlo Pk, CA USA.
   [Govindarajan, Prasanthi; Blomkalns, Andra L.] Stanford Univ, Dept Emergency Med, Sch Med, Stanford, CA 94305 USA.
   [Pinsky, Benjamin A.] Stanford Univ, Dept Pathol, Sch Med, Stanford, CA 94305 USA.
   [Wang, C. Jason] Stanford Univ, Sch Med, Dept Hlth Policy, Stanford, CA 94305 USA.
RP Altamirano, J (通讯作者)，Stanford Univ, Dept Pediat, Sch Med, 300 Pasteur Dr, Stanford, CA 94305 USA.
EM altamira@stanford.edu
FU Stanford School of Medicine Research Office; National Center for
   Research Resources; National Center for Advancing Translational
   Sciences, National Institutes of Health [UL1 TR001085]
FX We thank Jim Eagen, MA (Synapse School), Bob Bear, MBA (Synapse School),
   and the parents, students, and staff of the school for their support of
   the study. No compensation was received. The REDCap platform services at
   Stanford are subsidized by the Stanford School of Medicine Research
   Office and the National Center for Research Resources and the National
   Center for Advancing Translational Sciences, National Institutes of
   Health ( grant UL1 TR001085).
CR American Academy of Pediatrics, CHILDR COVID 19 STAT
   American Academy of Pediatrics, COVID 19 GUID SAF SC
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   Centers for Disease Control and Prevention, 2020, SCI BRIEF TRANSM SAR
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NR 20
TC 1
Z9 1
U1 0
U2 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2574-3805
J9 JAMA NETW OPEN
JI JAMA Netw. Open
PD FEB 17
PY 2022
VL 5
IS 2
AR e2148988
DI 10.1001/jamanetworkopen.2021.48988
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ZC4TF
UT WOS:000757513900008
PM 35175340
OA gold, Green Published
DA 2022-07-18
ER

PT J
AU Philippon, AL
   Legros, P
   Grattery, F
   Leygue, A
   Pierrot, V
   Faucher, S
   Khoury, A
   Pornin, A
   Truchot, J
   Bouilleau, G
AF Philippon, Anne-Laure
   Legros, Pauline
   Grattery, Fabien
   Leygue, Alexandra
   Pierrot, Virginie
   Faucher, Sebastien
   Khoury, Abdo
   Pornin, Antoine
   Truchot, Jennifer
   Bouilleau, Guillem
TI Innovating for a Safe Simulation Challenge During a Pandemic: An Avatar
   Simulation Concept
SO SIMULATION IN HEALTHCARE-JOURNAL OF THE SOCIETY FOR SIMULATION IN
   HEALTHCARE
LA English
DT Editorial Material
AB We present a new simulation-based challenge (Sim'Cup) concept, created in response to the COVID-19 pandemic. It took place in 2020, during the European Society of Emergency Medicine and the Societe Francaise de Medecine d'Urgence (SFMU) conferences. Usually, during the conferences, a Sim'Cup is held with onsite participants who are involved in a consecutive series of face-to-face simulations organized in 2 qualifying rounds, followed by a final round. When congresses were transformed into online events, the Sim'Cup had to evolve into a virtual format as well. We developed the e-Sim'Cup concept as follows: participants staying safely at home, piloting the trainers, as if they were their own avatar, in a simulation room with a full-scale high-fidelity manikin (Gaumard, Laerdal) using real-time scenarios. Participants gave instructions to the avatars through a smartphone and via a website. Each team participated in 2 scenarios. At the end of each scenario, teams had to undergo a self-debriefing, followed by a short debriefing with the organizers. Twenty-seven participants divided into 9 teams participated in 1 of the 2 e-Sim'Cup events.
   We evaluated the impact of this approach using the Educational Practices Questionnaire, and we also analyzed the participants' perception of their satisfaction and their feelings of improvement with this virtual format. Moreover, we conducted qualitative analyses of the self-debriefings. Thirteen participants filled out the questionnaire, giving a combined high Educational Practices Questionnaire score [72 (66.5-77) of 80], which reflects the presence of educational best practices during the e-Sim'Cups. They appreciated the adjusted Sim'Cup format and believed that they were able to improve their communication, clinical skills, and self-confidence. The qualitative analysis suggested that the approach was perceived as immersive by the 27 participants, with some challenges due to technical problems but an overall feeling of improvement regarding their crisis resource management skills. The hybrid remote simulation concept satisfied the participants who believed that it improved important skills in emergency medicine. The increasing number of remote activities and conferences lead us to believe that our e-Sim'Cup concept can be easily reproducible in any simulation center, as it requires only the application of the educational concept and either the use of the website or the use of some widely available technical devices.
C1 [Philippon, Anne-Laure] Hop La Pitie Salpetriere, AP HP, Emergency Dept, Paris, France.
   [Philippon, Anne-Laure] Univ Strasbourg, LISEC, Fac Educ Sci, Strasbourg, France.
   [Philippon, Anne-Laure; Legros, Pauline; Grattery, Fabien; Leygue, Alexandra; Pierrot, Virginie; Faucher, Sebastien; Pornin, Antoine; Bouilleau, Guillem] Chinon Hosp, Urgent E Sim Format, Chinon, France.
   [Legros, Pauline; Leygue, Alexandra; Pierrot, Virginie; Pornin, Antoine; Bouilleau, Guillem] Chinon Hosp, Emergency Dept, Chinon, France.
   [Faucher, Sebastien] Perpignan Hosp, Emergency Dept, Perpignan, France.
   [Khoury, Abdo] Dept Emergency Med & Crit Care, Besancon, France.
   [Truchot, Jennifer] Cochin Hosp, AP HP, Emergency Dept, Paris, France.
RP Philippon, AL (通讯作者)，Hop La Pitie Salpetriere, Emergency Dept, 83 Blvd Hop, F-75013 Paris, France.
EM annelaurephi@gmail.com; pauline.legros@outlook.fr; fabien@grattery.net;
   cleoalexj@yahoo.fr; virginie.33@gmail.com; sefa_595@hotmail.com;
   abdokhoury@hotmail.com; a.pornin@ch-chinon.fr; jenx73@hotmail.com;
   drbouilleau@gmail.com
NR 0
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1559-2332
EI 1559-713X
J9 SIMUL HEALTHC
JI Simul. Healthc.
PD APR
PY 2022
VL 17
IS 2
BP 138
EP 139
DI 10.1097/SIH.0000000000000652
PG 2
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA 0E6IB
UT WOS:000776782000010
PM 35307711
OA Green Published
DA 2022-07-18
ER

PT J
AU Alosco, ML
   Mariani, ML
   Adler, CH
   Balcer, LJ
   Bernick, C
   Au, RD
   Banks, SJ
   Barr, WB
   Bouix, S
   Cantu, RC
   Coleman, MJ
   Dodick, DW
   Farrer, LA
   Geda, YE
   Katz, DI
   Koerte, IK
   Kowall, NW
   Lin, ADP
   Marcus, DS
   Marek, KL
   McClean, MD
   McKee, AC
   Mez, J
   Palmisano, JN
   Peskind, ER
   Tripodis, Y
   Turner, RW
   Wethe, JV
   Cummings, JL
   Reiman, EM
   Shenton, ME
   Stern, RA
AF Alosco, Michael L.
   Mariani, Megan L.
   Adler, Charles H.
   Balcer, Laura J.
   Bernick, Charles
   Au, Rhoda
   Banks, Sarah J.
   Barr, William B.
   Bouix, Sylvain
   Cantu, Robert C.
   Coleman, Michael J.
   Dodick, David W.
   Farrer, Lindsay A.
   Geda, Yonas E.
   Katz, Douglas I.
   Koerte, Inga K.
   Kowall, Neil W.
   Lin, Alexander P.
   Marcus, Daniel S.
   Marek, Kenneth L.
   McClean, Michael D.
   McKee, Ann C.
   Mez, Jesse
   Palmisano, Joseph N.
   Peskind, Elaine R.
   Tripodis, Yorghos
   Turner, Robert W., II
   Wethe, Jennifer V.
   Cummings, Jeffrey L.
   Reiman, Eric M.
   Shenton, Martha E.
   Stern, Robert A.
CA DIAGNOSE CTE Res
TI Developing methods to detect and diagnose chronic traumatic
   encephalopathy during life: rationale, design, and methodology for the
   DIAGNOSE CTE Research Project
SO ALZHEIMERS RESEARCH & THERAPY
LA English
DT Article
DE Neurodegenerative disease; Biomarkers; Chronic traumatic encephalopathy;
   Cognitive function; Concussion; Football; Head trauma; MRI; MRS;
   National Football League; College football; Neuroimaging; Repetitive
   head impacts; Traumatic brain injury; Subconcussion; Traumatic
   encephalopathy syndrome; Positron emission tomography; Tau; Remote
   assessment
ID FOOTBALL LEAGUE PLAYERS; ALZHEIMERS ASSOCIATION WORKGROUPS; REPETITIVE
   HEAD IMPACTS; 1ST EXPOSURE; COGNITIVE IMPAIRMENT; NATIONAL INSTITUTE;
   RATING-SCALE; OLDER-ADULTS; NFL PLAYERS; MDS-UPDRS
AB Background: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that has been neuropathologically diagnosed in brain donors exposed to repetitive head impacts, including boxers and American football, soccer, ice hockey, and rugby players. CTE cannot yet be diagnosed during life. In December 2015, the National Institute of Neurological Disorders and Stroke awarded a seven-year grant (U01NS093334) to fund the "Diagnostics, Imaging, and Genetics Network for the Objective Study and Evaluation of Chronic Traumatic Encephalopathy (DIAGNOSE CTE) Research Project." The objectives of this multicenter project are to: develop in vivo fluid and neuroimaging biomarkers for CTE; characterize its clinical presentation; refine and validate clinical research diagnostic criteria (i.e., traumatic encephalopathy syndrome [TES]); examine repetitive head impact exposure, genetic, and other risk factors; and provide shared resources of anonymized data and biological samples to the research community. In this paper, we provide a detailed overview of the rationale, design, and methods for the DIAGNOSE CTE Research Project.
   Methods: The targeted sample and sample size was 240 male participants, ages 45-74, including 120 former professional football players, 60 former collegiate football players, and 60 asymptomatic participants without a history of head trauma or participation in organized contact sports. Participants were evaluated at one of four U.S. sites and underwent the following baseline procedures: neurological and neuropsychological examinations; tau and amyloid positron emission tomography; magnetic resonance imaging and spectroscopy; lumbar puncture; blood and saliva collection; and standardized self-report measures of neuropsychiatric, cognitive, and daily functioning. Study partners completed similar informant-report measures. Follow-up evaluations were intended to be in-person and at 3 years post-baseline. Multidisciplinary diagnostic consensus conferences are held, and the reliability and validity of TES diagnostic criteria are examined.
   Results: Participant enrollment and all baseline evaluations were completed in February 2020. Three-year follow-up evaluations began in October 2019. However, in-person evaluation ceased with the COVID-19 pandemic, and resumed as remote, 4-year follow-up evaluations (including telephone-, online-, and videoconference-based cognitive, neuropsychiatric, and neurologic examinations, as well as in-home blood draw) in February 2021.
   Conclusions: Findings from the DIAGNOSE CTE Research Project should facilitate detection and diagnosis of CTE during life, and thereby accelerate research on risk factors, mechanisms, epidemiology, treatment, and prevention of CTE.
C1 [Alosco, Michael L.; McKee, Ann C.; Stern, Robert A.] Boston Univ, Sch Med, Dept Neurol, Alzheimers Dis Res Ctr,CTE Ctr, Boston, MA 02118 USA.
   [Mariani, Megan L.] Boston Univ, Sch Med, CTE Ctr, Boston, MA 02118 USA.
   [Adler, Charles H.; Dodick, David W.] Mayo Clin Arizona, Dept Neurol, Mayo Clin, Coll Med, Scottsdale, AZ USA.
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   [Bernick, Charles] Cleveland Clin, Lou Ruvo Ctr Brain Hlth, Las Vegas, NV USA.
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   [Au, Rhoda] Slone Epidemiol Ctr, Boston, MA USA.
   [Banks, Sarah J.] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA.
   [Banks, Sarah J.] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
   [Bouix, Sylvain; Koerte, Inga K.; Shenton, Martha E.] Harvard Med Sch, Brigham & Womens Hosp, Dept Psychiat, Psychiat Neuroimaging Lab, Boston, MA 02115 USA.
   [Cantu, Robert C.; Kowall, Neil W.] Boston Univ, Sch Med, Dept Neurol, Alzheimers Dis Res Ctr, Boston, MA 02118 USA.
   [Cantu, Robert C.; Kowall, Neil W.] Boston Univ, Sch Med, Dept Neurosurg, Alzheimers Dis Res Ctr, Boston, MA 02118 USA.
   [Coleman, Michael J.] Brigham & Womens Hosp, Psychiat Neuroimaging Lab, 75 Francis St, Boston, MA 02115 USA.
   [Farrer, Lindsay A.] BU Sch Med & Publ Hlth, Dept Med Biomed Genet, Boston, MA USA.
   [Farrer, Lindsay A.] BU Sch Med & Publ Hlth, Dept Neurol, Boston, MA USA.
   [Farrer, Lindsay A.] BU Sch Med & Publ Hlth, Dept Ophthalmol, Boston, MA USA.
   [Farrer, Lindsay A.] BU Sch Med & Publ Hlth, Dept Epidemiol, Boston, MA USA.
   [Farrer, Lindsay A.] BU Sch Med & Publ Hlth, Dept Biostat, Boston, MA USA.
   [Geda, Yonas E.] Barrow Neurol Inst, Dept Neurol, Alzheimers Dis & Memory Disorders Program, Phoenix, AZ 85013 USA.
   [Au, Rhoda; Katz, Douglas I.] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA.
   [Lin, Alexander P.] Harvard Med Sch, Brigham & Womens Hosp, Psychiat Neuroimaging Lab, Ctr Clin Spect,Dept Radiol,Dept Psychiat, Boston, MA 02115 USA.
   [Marcus, Daniel S.] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63110 USA.
   [Marek, Kenneth L.] Invicro LLC, Inst Neurodegenerat Disorders, New Haven, CT USA.
   [McClean, Michael D.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA.
   [Mez, Jesse] Boston Univ, Sch Med, Framingham Heart Study, Alzheimers Dis Res Ctr,CTE Ctr,Dept Neurol, Boston, MA 02118 USA.
   [Palmisano, Joseph N.] Boston Univ, Sch Publ Hlth, Biostat & Epidemiol Data Analyt Ctr BEDAC, Boston, MA USA.
   [Peskind, Elaine R.] Univ Washington, Dept Psychiat & Behav Sci, VA Northwest Mental Illness Res Educ & Clin Ctr, Sch Med,VA Puget Sound Hlth Care Syst, Seattle, WA 98195 USA.
   [Tripodis, Yorghos] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.
   [Turner, Robert W., II] George Washington Univ, Sch Med & Hlth Sci, Dept Clin Res & Leadership, Washington, DC 20052 USA.
   [Wethe, Jennifer V.] Mayo Clin Arizona, Mayo Clin, Sch Med, Dept Psychiat & Psychol, Scottsdale, AZ USA.
   [Cummings, Jeffrey L.] Univ Nevada, Dept Brain Hlth, Sch Integrated Hlth Sci, Chambers Grundy Ctr Transformat Neurosci, Las Vegas, NV 89154 USA.
   [Reiman, Eric M.] Arizona State Univ, Univ Arizona, Translat Genom Res Inst, Banner Alzheimers Inst, Phoenix, AZ USA.
   [Reiman, Eric M.] Arizona Alzheimers Consortium, Phoenix, AZ USA.
   [Shenton, Martha E.] Harvard Med Sch, Brigham & Womens Hosp, Dept Radiol, Psychiat Neuroimaging Lab, Boston, MA 02115 USA.
   [Stern, Robert A.] Boston Univ, Sch Med, Dept Neurosurg, Alzheimers Dis Res Ctr,CTE Ctr, Boston, MA 02118 USA.
   [Stern, Robert A.] Boston Univ, Sch Med, Dept Anat & Neurobiol, Alzheimers Dis Res Ctr,CTE Ctr, Boston, MA 02118 USA.
   [Bernick, Charles] Univ Washington, Dept Neurol, Seattle, WA 98195 USA.
   [Au, Rhoda] Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA 02118 USA.
   [Au, Rhoda] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
   [Katz, Douglas I.] Encompass Hlth Braintree Rehabil Hosp, Braintree, MA USA.
   [Koerte, Inga K.] Ludwigs Maximilians Univ, Dept Child & Adolescent Psychiat, Psychosomat & Psychotherapy, cBRAIN, Munich, Germany.
   [Kowall, Neil W.; McKee, Ann C.] VA Boston Healthcare Syst, Boston, MA USA.
RP Stern, RA (通讯作者)，Boston Univ, Sch Med, Dept Neurol, Alzheimers Dis Res Ctr,CTE Ctr, Boston, MA 02118 USA.; Stern, RA (通讯作者)，Boston Univ, Sch Med, Dept Neurosurg, Alzheimers Dis Res Ctr,CTE Ctr, Boston, MA 02118 USA.; Stern, RA (通讯作者)，Boston Univ, Sch Med, Dept Anat & Neurobiol, Alzheimers Dis Res Ctr,CTE Ctr, Boston, MA 02118 USA.
EM bobstern@bu.edu
RI Adler, Charles/ABD-5276-2021
OI Bouix, Sylvain/0000-0003-1326-6054
FU National Institutes of Health [U01NS093334, P30AG13846, R01NS078337,
   K23NS102399, P30AG019610, K01AG054762, R01NS100952, K00NS113419];
   National Center for Advancing Translational Sciences, National
   Institutes of Health, through BU-CTSI Grant [1UL1TR001430]; National
   Institute of Neurological Disorders and Stroke (NINDS) [U01NS093334]
FX This work was supported by grants from the National Institutes of Health
   (U01NS093334; P30AG13846; R01NS078337; K23NS102399; P30AG019610;
   K01AG054762; R01NS100952; K00NS113419). This publication was supported
   by the National Center for Advancing Translational Sciences, National
   Institutes of Health, through BU-CTSI Grant Number 1UL1TR001430. The
   primary funding source is the National Institute of Neurological
   Disorders and Stroke (NINDS), through a U01 Research Project Cooperative
   Agreement (U01NS093334).
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NR 180
TC 4
Z9 4
U1 7
U2 34
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-9193
J9 ALZHEIMERS RES THER
JI Alzheimers Res. Ther.
PD AUG 12
PY 2021
VL 13
IS 1
AR 136
DI 10.1186/s13195-021-00872-x
PG 23
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA UA6ZN
UT WOS:000685308500001
PM 34384490
OA gold, Green Published
DA 2022-07-18
ER

PT J
AU Ciaranello, A
   Goehringer, C
   Nelson, SB
   Ruark, LJ
   Pollock, NR
AF Ciaranello, Andrea
   Goehringer, Cathryn
   Nelson, Sandra B.
   Ruark, Liz J.
   Pollock, Nira R.
TI Lessons Learned From Implementation of SARS-CoV-2 Screening in K-12
   Public Schools in Massachusetts
SO OPEN FORUM INFECTIOUS DISEASES
LA English
DT Article
DE K-12 schools; mitigation; prevention; SARS-CoV-2; screening; testing
AB In-person learning provides substantial benefits for K-12 school students. Risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among educators, staff, students, and household members can be markedly reduced by mitigation measures including masking, ventilation, and hygiene. In addition to these measures, where community transmission is moderate to high, regular SARS-CoV-2 screening testing is recommended by recent Centers for Disease Control and Prevention (CDC) guidance for unvaccinated K-12 students and staff, and supported financially by CDC and Department of Health and Human Services initiatives. Screening can provides an added layer of risk reduction, as well as data and reassurance about in-school transmission. Financial and logistical constraints have challenged implementation of screening in public schools. We report lessons learned from a collaborative of public K-12 schools implementing and evaluating screening programs, including details of population screened, site of specimen collection, assay selection, pooled testing, and resources needed. This work supported the development of a state-wide screening program and led to dissemination of online technical resources that may support other public schools in implementing CDC guidance.
C1 [Ciaranello, Andrea] Massachusetts Gen Hosp, Med Practice & Valuat Ctr, Div Infect Dis, Boston, MA 02114 USA.
   [Goehringer, Cathryn; Ruark, Liz J.] COVID 19 Response Advisors, Washington, DC USA.
   [Goehringer, Cathryn] Educ Fdn, Wellesley, MA USA.
   [Nelson, Sandra B.] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA.
   [Ruark, Liz J.] Covidsafeschools Org, Harvard, MA USA.
   [Pollock, Nira R.] Boston Childrens Hosp, Dept Lab Med, Boston, MA USA.
RP Ciaranello, A (通讯作者)，100 Cambridge St,Room 1670, Boston, MA 02114 USA.
EM aciaranello@mgh.harvard.edu
CR Bilinski A, 2021, ANN INTERN MED, V174, P1090, DOI [10.7326/M21-0600, 10.1101/2021.01.27.21250388]
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   Centers for Disease Control and Prevention, 2020, COVID 19 INT GUID US
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NR 15
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Z9 3
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U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 2328-8957
J9 OPEN FORUM INFECT DI
JI Open Forum Infect. Dis.
PD AUG 1
PY 2021
VL 8
IS 8
AR ofab287
DI 10.1093/ofid/ofab287
EA JUN 2021
PG 5
WC Immunology; Infectious Diseases; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Infectious Diseases; Microbiology
GA YW7JE
UT WOS:000753590400043
PM 34395706
OA Green Published, gold
DA 2022-07-18
ER

PT J
AU Ou, ZH
   Ouzounis, C
   Wang, DX
   Sun, WY
   Li, JH
   Chen, WJ
   Marliere, P
   Danchin, A
AF Ou, Zhihua
   Ouzounis, Christos
   Wang, Daxi
   Sun, Wanying
   Li, Junhua
   Chen, Weijun
   Marliere, Philippe
   Danchin, Antoine
TI A Path toward SARS-CoV-2 Attenuation: Metabolic Pressure on CTP
   Synthesis Rules the Virus Evolution
SO GENOME BIOLOGY AND EVOLUTION
LA English
DT Article
DE ABCE1; cytoophidia; Maxwell's demon; Nsp1; phosphoribosyltransferase;
   queuine
ID ACUTE RESPIRATORY SYNDROME; PURINE SALVAGE PATHWAY; CODON USAGE BIAS;
   URACIL PHOSPHORIBOSYLTRANSFERASE; PYRIMIDINE METABOLISM; SYNDROME
   CORONAVIRUS; BASE COMPOSITION; BAT CORONAVIRUS; PROTEIN; HOST
AB In the context of the COVID-19 pandemic, we describe here the singular metabolic background that constrains enveloped RNA viruses to evolve toward likely attenuation in the long term, possibly after a step of increased pathogenicity. Cytidine triphosphate (CTP) is at the crossroad of the processes allowing SARS-CoV-2 to multiply, because CTP is in demand for four essential metabolic steps. It is a building block of the virus genome, it is required for synthesis of the cytosine-based liponucleotide precursors of the viral envelope, it is a critical building block of the host transfer RNAs synthesis and it is required for synthesis of dolichol-phosphate, a precursor of viral protein glycosylation. The CCA 3'-end of all the transfer RNAs required to translate the RNA genome and further transcripts into the proteins used to build active virus copies is not coded in the human genome. It must be synthesized de novo from CTP and ATP. Furthermore, intermediary metabolism is built on compulsory steps of synthesis and salvage of cytosine-based metabolites via uridine triphosphate that keep limiting CTP availability. As a consequence, accidental replication errors tend to replace cytosine by uracil in the genome, unless recombination events allow the sequence to return to its ancestral sequences. We document some of the consequences of this situation in the function of viral proteins. This unique metabolic setup allowed us to highlight and provide a raison d'etre to viperin, an enzyme of innate antiviral immunity, which synthesizes 3'-deoxy-3',4'-didehydro-CTP as an extremely efficient antiviral nucleotide.
C1 [Ou, Zhihua; Wang, Daxi; Sun, Wanying; Li, Junhua] BGI Shenzhen, Shenzhen, Peoples R China.
   [Ou, Zhihua; Wang, Daxi; Sun, Wanying; Li, Junhua; Chen, Weijun] BGI Shenzhen, Shenzhen Key Lab Unknown Pathogen Identificat, Shenzhen, Peoples R China.
   [Ouzounis, Christos] Chem Proc & Energy Resources Inst, Ctr Res & Technol Hellas, Biol Computat & Proc Lab, Thessaloniki, Greece.
   [Sun, Wanying] Univ Chinese Acad Sci, BGI Educ Ctr, Shenzhen, Peoples R China.
   [Chen, Weijun] BGI Shenzhen, BGI PathoGenesis Pharmaceut Technol, Shenzhen, Peoples R China.
   [Marliere, Philippe] European Syndicate Synthet Scientists & Industria, TESSSI, Paris, France.
   [Danchin, Antoine] Inst Cochin, Kodikos Labs, Paris, France.
   [Danchin, Antoine] Univ Hong Kong, Li KaShing Fac Med, Sch Biomed Sci, Pokfulam, Hong Kong, Peoples R China.
RP Chen, WJ (通讯作者)，BGI Shenzhen, Shenzhen Key Lab Unknown Pathogen Identificat, Shenzhen, Peoples R China.; Chen, WJ (通讯作者)，BGI Shenzhen, BGI PathoGenesis Pharmaceut Technol, Shenzhen, Peoples R China.; Danchin, A (通讯作者)，Inst Cochin, Kodikos Labs, Paris, France.; Danchin, A (通讯作者)，Univ Hong Kong, Li KaShing Fac Med, Sch Biomed Sci, Pokfulam, Hong Kong, Peoples R China.
EM chenwj@bgi.com; antoine.danchin@normalesup.org
RI Li, Junhua/AAG-3919-2019; Ouzounis, Christos A/G-2302-2010
OI Li, Junhua/0000-0001-6784-1873; Ouzounis, Christos
   A/0000-0002-0086-8657; Danchin, Antoine/0000-0002-6350-5001
FU Stellate Therapeutics; National Science and Technology Major Project of
   China [2017ZX10303406]; Ministry of Science and Technology
   [2020YFC0841400]; Guangdong province, China [2020B111107001,
   2020B111108001]
FX This work was supported by Stellate Therapeutics and the National
   Science and Technology Major Project of China (No. 2017ZX10303406), the
   emergency grants for prevention and control of SARS-CoV-2 of Ministry of
   Science and Technology (2020YFC0841400) and Guangdong province, China
   (2020B111107001, 2020B111108001). We warmly thank Prof. Huanming Yang,
   Dr Ziqing Deng, and Dr Minfeng Xiao for their constructive communication
   in study design and data interpretation. Our thanks also go to Mr Jielun
   Cai and Miss Xinyi Cheng for their assistance in data preparation.
   Thanks also to Pierre-Yves Bourguignon for his analysis of the cytosine
   complement of the virus and to Agnieszka Sekowska for her comments on
   metabolic pathways. We thank all the authors who shared genomic data in
   public database, and an acknowledgment table for sequences retrieved
   from GISAID (Elbe and Buckland-Merrett 2017) is provided (supplementary
   table S2, SupplementaryMaterial online).
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NR 130
TC 11
Z9 11
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1759-6653
J9 GENOME BIOL EVOL
JI Genome Biol. Evol.
PD DEC
PY 2020
VL 12
IS 12
BP 2467
EP 2485
DI 10.1093/gbe/evaa229
PG 19
WC Evolutionary Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Evolutionary Biology; Genetics & Heredity
GA PQ5EJ
UT WOS:000606568300021
PM 33125064
OA Green Published, Green Submitted, gold
DA 2022-07-18
ER

PT J
AU Nakashima, A
   Shima, T
   Aoki, A
   Kawaguchi, M
   Yasuda, I
   Tsuda, S
   Yoneda, S
   Yamaki-Ushijima, A
   Cheng, SB
   Sharma, S
   Saito, S
AF Nakashima, Akitoshi
   Shima, Tomoko
   Aoki, Aiko
   Kawaguchi, Mihoko
   Yasuda, Ippei
   Tsuda, Sayaka
   Yoneda, Satoshi
   Yamaki-Ushijima, Akemi
   Cheng, Shibin
   Sharma, Surendra
   Saito, Shigeru
TI Placental autophagy failure: A risk factor for preeclampsia
SO JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
LA English
DT Article
DE autophagy; ER stress; hypoxia; preeclampsia; TFEB
ID REGULATORY T-CELLS; GENOME-WIDE ASSOCIATION; CROHN-DISEASE;
   IMPLANTATION; PREGNANCY; LC3; PATHOGENESIS; EXPRESSION; HYPOXIA; STRESS
AB Hypertensive disorders of pregnancy, including preeclampsia, directly affect maternal and perinatal morbidity and mortality. As the pathophysiology of preeclampsia is multi-factorial and has been studied using different approaches, we have demonstrated that impaired autophagy is an intertwined risk factor for preeclampsia. This concept has been verified in bothin vitroandin vivoexperiments. Autophagy is primarily involved in maintaining cellular homeostasis, and in immune regulation, longevity, cytokines secretion and a variety of other biological functions. Here, we review the role of autophagy in normal embryogenesis and placentation. Once placental autophagy is impaired by metabolic stress such as hypoxia, endoplasmic reticulum stress or starvation, placental development could be disrupted, resulting in functional maladaptations at the maternal-fetal interface. These malfunctions may result in fetal growth restriction or preeclampsia.
C1 [Nakashima, Akitoshi; Shima, Tomoko; Aoki, Aiko; Kawaguchi, Mihoko; Yasuda, Ippei; Tsuda, Sayaka; Yoneda, Satoshi; Yamaki-Ushijima, Akemi; Saito, Shigeru] Univ Toyama, Dept Obstet & Gynecol, Fac Med, 2630 Sugitani, Toyama 9300194, Japan.
   [Cheng, Shibin; Sharma, Surendra] Brown Univ, Women & Infants Hosp, Dept Pediat, Providence, RI 02908 USA.
RP Nakashima, A (通讯作者)，Univ Toyama, Dept Obstet & Gynecol, Fac Med, 2630 Sugitani, Toyama 9300194, Japan.
EM akinaka@med.u-toyama.ac.jp
FU Takahashi Industrial and Economic Research Foundation; Toyama University
   Hospital Grant [040200-59200003502, 040200-59200003513]; JSPS KAKENHI
   [JP19K09750, JP17K11221]
FX This paper was based on the presentation in the 72nd annual congress of
   the Japan Society of Obstetrics and Gynecology, which was organized
   online during the COVID-19 pandemic. We thank Prof. Daisuke Aoki and
   members of the OB/GYN department at Keio University School of Medicine,
   who run the congress. For our work, we thank Prof. Tamotsu Yoshimori
   (Osaka University) for providing us the experimental materials, Prof.
   Masahito Ikawa (Osaka University) for constructing placenta-specific
   Atg7 knockout mice, Prof. Aikou Okamoto for providing the HchEpC1b
   trophoblast cell line and all the staff at the Department of Obstetrics
   and Gynecology, University of Toyama, for recruiting patients' samples.
   This research was supported by grants from the Takahashi Industrial and
   Economic Research Foundation, Toyama University Hospital Grant (Grant
   Numbers 040200-59200003502 and 040200-59200003513) and JSPS KAKENHI
   (Grant Numbers JP19K09750 and JP17K11221). We would also like to thank
   Editage (www.editage.com) for English language editing.
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NR 62
TC 2
Z9 2
U1 2
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1341-8076
EI 1447-0756
J9 J OBSTET GYNAECOL RE
JI J. Obstet. Gynaecol. Res.
PD DEC
PY 2020
VL 46
IS 12
BP 2497
EP 2504
DI 10.1111/jog.14489
EA SEP 2020
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA OY9BW
UT WOS:000569510500001
PM 32939889
DA 2022-07-18
ER

PT J
AU Evans, L
   Rhodes, A
   Alhazzani, W
   Antonelli, M
   Coopersmith, CM
   French, C
   Machado, FR
   Mcintyre, L
   Ostermann, M
   Prescott, HC
   Schorr, C
   Simpson, S
   Wiersinga, WJ
   Alshamsi, F
   Angus, DC
   Arabi, Y
   Azevedo, L
   Beale, R
   Beilman, G
   Belley-Cote, E
   Burry, L
   Cecconi, M
   Centofanti, J
   Yataco, AC
   De Waele, J
   Dellinger, RP
   Doi, K
   Du, B
   Estenssoro, E
   Ferrer, R
   Gomersall, C
   Hodgson, C
   Moller, MH
   Iwashyna, T
   Jacob, S
   Kleinpell, R
   Klompas, M
   Koh, Y
   Kumar, A
   Kwizera, A
   Lobo, S
   Masur, H
   McGloughlin, S
   Mehta, S
   Mehta, Y
   Mer, M
   Nunnally, M
   Oczkowski, S
   Osborn, T
   Papathanassoglou, E
   Perner, A
   Puskarich, M
   Roberts, J
   Schweickert, W
   Seckel, M
   Sevransky, J
   Sprung, CL
   Welte, T
   Zimmerman, J
   Levy, M
AF Evans, Laura
   Rhodes, Andrew
   Alhazzani, Waleed
   Antonelli, Massimo
   Coopersmith, Craig M.
   French, Craig
   Machado, Flavia R.
   Mcintyre, Lauralyn
   Ostermann, Marlies
   Prescott, Hallie C.
   Schorr, Christa
   Simpson, Steven
   Wiersinga, W. Joost
   Alshamsi, Fayez
   Angus, Derek C.
   Arabi, Yaseen
   Azevedo, Luciano
   Beale, Richard
   Beilman, Gregory
   Belley-Cote, Emilie
   Burry, Lisa
   Cecconi, Maurizio
   Centofanti, John
   Coz Yataco, Angel
   De Waele, Jan
   Dellinger, R. Phillip
   Doi, Kent
   Du, Bin
   Estenssoro, Elisa
   Ferrer, Ricard
   Gomersall, Charles
   Hodgson, Carol
   Hylander Moller, Morten
   Iwashyna, Theodore
   Jacob, Shevin
   Kleinpell, Ruth
   Klompas, Michael
   Koh, Younsuck
   Kumar, Anand
   Kwizera, Arthur
   Lobo, Suzana
   Masur, Henry
   McGloughlin, Steven
   Mehta, Sangeeta
   Mehta, Yatin
   Mer, Mervyn
   Nunnally, Mark
   Oczkowski, Simon
   Osborn, Tiffany
   Papathanassoglou, Elizabeth
   Perner, Anders
   Puskarich, Michael
   Roberts, Jason
   Schweickert, William
   Seckel, Maureen
   Sevransky, Jonathan
   Sprung, Charles L.
   Welte, Tobias
   Zimmerman, Janice
   Levy, Mitchell
TI Surviving Sepsis Campaign: International Guidelines for Management of
   Sepsis and Septic Shock 2021
SO CRITICAL CARE MEDICINE
LA English
DT Article
DE adults; evidence-based medicine; guidelines; sepsis; septic shock
ID INTENSIVE-CARE-UNIT; CRITICALLY-ILL PATIENTS; RESISTANT
   STAPHYLOCOCCUS-AUREUS; RESPIRATORY-DISTRESS-SYNDROME;
   INFECTIOUS-DISEASES-SOCIETY; ACUTE LUNG INJURY; GOAL-DIRECTED THERAPY;
   CLINICAL-PRACTICE GUIDELINES; INVASIVE FUNGAL-INFECTIONS;
   RENAL-REPLACEMENT THERAPY
C1 [Evans, Laura] Univ Washington, Div Pulm Crit Care & Sleep Med, Seattle, WA 98195 USA.
   [Rhodes, Andrew] Georges Univ London, Adult Crit Care, St Georges Univ Hosp NHS Fdn Trust, London, England.
   [Rhodes, Andrew] St Georges Univ, London, England.
   [Alhazzani, Waleed] McMaster Univ, Dept Med, Hamilton, ON, Canada.
   [Antonelli, Massimo] Policlin Univ Gemelli IRCCS, Dipartimento Sci Emergenza Anestesiol & Rianimazi, Rome, Italy.
   [Coopersmith, Craig M.] Emory Univ, Sch Med, Atlanta, GA USA.
   [French, Craig] Western Hlth, Melbourne, Vic, Australia.
   [Machado, Flavia R.] Fed Univ Sao Paolo, Anesthesiol Pain & Intens Care Dept, Sao Paulo, Brazil.
   [Mcintyre, Lauralyn] Ottawa Hosp, Ottawa, ON, Canada.
   [Ostermann, Marlies] Guys & St Thomas Hosp, London, England.
   [Prescott, Hallie C.] Univ Michigan, VA Ctr Clin Management Res, Ann Arbor, MI USA.
   [Prescott, Hallie C.] Univ Michigan, Ann Arbor, MI USA.
   [Schorr, Christa] Cooper Hlth Syst, Camden, NJ USA.
   [Simpson, Steven] Univ Kansas, Med Ctr, Kansas City, MO USA.
   [Wiersinga, W. Joost] Univ Amsterdam, Div Infect Dis, ESCMID Study Grp Bloodstream Infect, Endocarditis & Sepsis,Amsterdam UMC, Amsterdam, Netherlands.
   [Alshamsi, Fayez] United Arab Emirates Univ, Coll Med & Hlth Sciences, Dept Internal Med, Al Ain, U Arab Emirates.
   [Angus, Derek C.] Univ Pittsburgh, Crit Care Med CRISMA Lab, Pittsburgh, PA USA.
   [Arabi, Yaseen] King Saud Bin Abdulaziz Univ Hlth Sci, King Abdullah Int Med Res Ctr, Intens Care Dept, Minist Natl Guard Hlth Affairs, Riyadh, Saudi Arabia.
   [Azevedo, Luciano] Univ Sao Paulo, Sch Med, Sao Paulo, Brazil.
   [Beale, Richard] Guys & St Thomas Hosp, London, England.
   [Beilman, Gregory] Univ Minnesota, Minneapolis, MN USA.
   [Belley-Cote, Emilie] Populat Hlth Res Inst, Hamilton, ON, Canada.
   [Burry, Lisa] Mt Sinai Hosp, Toronto, ON, Canada.
   [Burry, Lisa] Univ Toronto, Leslie Dan Fac Pharm, Toronto, ON, Canada.
   [Cecconi, Maurizio] Humanitas Univ Pieve Emanuele, Dept Biomed Sci, Milan, Italy.
   [Cecconi, Maurizio] IRCCS Humanitas Res Hosp, Dept Anaesthesia & Intens Care, Milan, Italy.
   [Centofanti, John] McMaster Univ, Dept Anesthesia, Hamilton, ON, Canada.
   [Coz Yataco, Angel] Univ Kentucky, Lexington Vet Affairs Med Ctr, Coll Med, Lexington, KY USA.
   [De Waele, Jan] Ghent Univ Hosp, Ghent, Belgium.
   [Dellinger, R. Phillip] Cooper Hlth Syst, Camden, NJ USA.
   [Doi, Kent] Univ Tokyo, Tokyo, Japan.
   [Du, Bin] Peking Union Med Coll Hosp, Med ICU, Beijing, Peoples R China.
   [Estenssoro, Elisa] Hosp Int Agudos San Martin Plata, Buenos Aires, Argentina.
   [Ferrer, Ricard] Vall Hebron Univ Hosp, Vall Hebron Inst Recerca, Intens Care Dept, Barcelona, Spain.
   [Gomersall, Charles] Prince Wales Hosp, Hong Kong, Peoples R China.
   [Hodgson, Carol] Monash Univ, Australian & New Zealand Intens Care Res Centre, Melbourne, Vic, Australia.
   [Hylander Moller, Morten] Copenhagen Univ Hosp, Dept Intens Care, Rigshosp, Copenhagen, Denmark.
   [Iwashyna, Theodore] Univ Michigan Hlth Syst, Ann Arbor, MI USA.
   [Jacob, Shevin] Liverpool Sch Tropical Med, Liverpool, Merseyside, England.
   [Kleinpell, Ruth] Vanderbilt Univ, Nashville, TN USA.
   [Klompas, Michael] Brigham & Womens Hosp, Dept Med, Boston, MA USA.
   [Klompas, Michael] Harvard Med Sch, Dept Populat Med, Boston, MA USA.
   [Koh, Younsuck] Harvard Med Sch, Harvard Pilgrim Hlth Care Inst, Boston, MA USA.
   [Koh, Younsuck] Univ Ulsan, ASAN Med Ctr, Coll Med, Seoul, South Korea.
   [Kumar, Anand] Univ Manitoba, Winnipeg, MB, Canada.
   [Kwizera, Arthur] Makerere Univ, Coll Hlth Sci, Kampala, Uganda.
   [Lobo, Suzana] Fac Med Sao Jose do Rio Preto, Intens Care Div, Sao Paulo, Brazil.
   [Masur, Henry] NIH Clin Ctr, Crit Care Med Dept, Bethesda, MD USA.
   [McGloughlin, Steven] Alfred Hlth, Melbourne, Vic, Australia.
   [Mehta, Sangeeta] Mt Sinai Hosp, Toronto, ON, Canada.
   [Mehta, Yatin] Medanta Med, Gurugram, Haryana, India.
   [Mer, Mervyn] Charlotte Maxeke Johannesburg Acad Hosp, Fac Hlth Sci, Johannesburg, South Africa.
   [Nunnally, Mark] Univ Witwatersrand, Johannesburg, South Africa.
   [Nunnally, Mark] New York Univ, Sch Med, New York, NY USA.
   [Oczkowski, Simon] McMaster Univ, Dept Med, Hamilton, ON, Canada.
   [Osborn, Tiffany] Washington Univ, Sch Med, St Louis, MO USA.
   [Papathanassoglou, Elizabeth] Univ Alberta, Fac Nursing, Edmonton, AB, Canada.
   [Perner, Anders] Rigshosp, Copenhagen, Denmark.
   [Puskarich, Michael] Univ Minnesota, Hennepin Cty Med Ctr, Minneapolis, MN USA.
   [Roberts, Jason] Univ Queensland, Clin Res Ctr, Fac Med, Brisbane, Qld, Australia.
   [Schweickert, William] Royal Brisbane & Womens Hosp, Dept Pharm, Brisbane, Qld, Australia.
   [Roberts, Jason] Royal Brisbane & Womens Hosp, Dept Intens Care Med, Brisbane, Qld, Australia.
   [Schweickert, William] Univ Montpellier, Univ Nimes Hosp, Div Anaesthesiol Crit Care Emergency & Pain Med, Nimes, France.
   [Schweickert, William] Univ Penn, Philadelphia, PA USA.
   [Seckel, Maureen] ChristianaCare, Newark, DE USA.
   [Sevransky, Jonathan] Emory Univ, Sch Med, Atlanta, GA USA.
   [Sprung, Charles L.] Hebrew Univ Jerusalem, Fac Med, Jerusalem, Israel.
   [Welte, Tobias] Hadassah Med Ctr, Dept Anesthesiol Crit Care & Pain Med, Jerusalem, Israel.
   [Zimmerman, Janice] Hannover Med Sch, Hannover, Germany.
   [Zimmerman, Janice] German Ctr Lung Res DZL, Hannover, Germany.
   [Levy, Mitchell] World Federat Intens & Crit Care, Brussels, Belgium.
   [Zimmerman, Janice] Brown Univ, Warren Alpert Sch Med, Providence, RI USA.
   [Levy, Mitchell] Rhode Isl Hosp, Providence, RI USA.
RP Evans, L (通讯作者)，Univ Washington, Div Pulm Crit Care & Sleep Med, Seattle, WA 98195 USA.
EM leevans@uw.edu
RI Jacob, Shevin/CAF-0449-2022; Azevedo, Luciano CP/H-2652-2012; Ferrer,
   Ricard/K-9022-2017; Ostermann, Marlies/B-8777-2015; Puskarich,
   Michael/N-7849-2014
OI Azevedo, Luciano CP/0000-0001-6759-3910; Ferrer,
   Ricard/0000-0002-4859-4747; De Waele, Jan/0000-0003-1017-9748;
   Ostermann, Marlies/0000-0001-9500-9080; Puskarich,
   Michael/0000-0001-6358-4670; Prescott, Hallie/0000-0002-8442-6724
FU GE; Toray-Estor; Baxter; Pfizer; Orion; Maquet; Fisher and Paykel;
   Ferring Pharmaceuticals, Inc; ALung Technologies, Inc; Roche; Bayer;
   Grifols; MSD; Shionogi; Toray; Jafron; Cytosorbents; UK National
   Institute for Health Research; Liverpool School of Tropical Medicine;
   Up-to-Date; Edwards; Nestle; Viven Inc; Inflammatrix; Beckman;
   Foundation for Barnes Jewish Hospital; Pfizer Denmark; The Medicines
   Company; Cardeas Pharma; Biomerieux; QPEX; Cipla; Marcus Foundation-PI
   VICTAS Trial; Astellas; AstraZeneca; Boehringer; Basilea; Berlin-Chemie;
   Infectopharm; Mundipharma; Novartis; DFG; EU; BMBF; Insmed
FX Dr. Alhazzani is the Chair of the Guidelines Chapter for the Saudi
   Critical Care Society and is the chair of the guidelines in intensive
   care, development and evaluation (GUIDE) Group, McMaster University
   Canada. Dr. Antonelli received funding from GE, Toray-Estor, Baxter,
   Pfizer, Orion, Maquet, and Fisher and Paykel; he was on the board of
   Baxter and Pfizer, and is a member of the executive committee and past
   president of Societa Italiana di Anestesia Rianimazione e Terapia
   Intensiva (SIAARTI). Dr. French contributed to the ANZICS Guidelines and
   the National COVID-19 Guidelines. Dr. Machado is a member of the
   Executive Committee for the Basics Study (for which Baxter provided the
   drugs and logistics) and AMIB. Dr. McIntyre is a member of the Canadian
   Critical Care Society and serves on the Surviving Sepsis Campaign
   Steering Committee. Dr. Ostermann is a council member of the Intensive
   Care Society UK and member of the Renal Association UK and World Sepsis
   Alliance. Dr. Prescott is a member of the ATS Critical Care Program
   Committee. Dr. Simpson is the president-elect and Chair of CHEST, is a
   member of the board of directors and medical director of Sepsis
   Alliance, and Chair of the Sepsis Institute Advisory Board. Dr.
   Wiersinga is a member of ISF, ESCIMID, and SWAB. Dr. Angus received
   funding from Ferring Pharmaceuticals, Inc and ALung Technologies, Inc.
   Dr. Beale provides consultancy services for Philips Healthcare with his
   time billed by his institution. Dr. Beilman is the president of the
   Surgical Infection Society. Dr. Belley-Cote received grants from Roche
   and Bayer and is a panel member on the Saudi Critical Care Society
   COVID-19 Thrombosis Guidelines. Dr. Cecconi is a consultant for Edwards
   Lifesciences, Cheetah Medical, and Directed Systems and is President of
   the European Society of Intensive Care Medicine. Dr. Coz is a board
   member of the American College of Chest Physicians. Dr. De Waele
   consulted for Accelerate, Bayer, Grifols, Pfizer, and MSD with all
   honoraria paid to Ghent University; he is a Senior Clinical Investigator
   with the Research Foundation Flanders. Dr. Dellinger serves as an expert
   witness on occasional medical legal case reviews. Dr. Doi is a member of
   the Japanese Society of Intensive Care Medicine. Dr. Du is a member of
   the Chinese Society of Critical Care Medicine and the Chinese College of
   Intensive Care Medicine. Dr. Ferrer received funding from Grifols, MSD,
   Pfizer, Shionogi, Toray, Jafron, and Cytosorbents; he is a member of
   SEMICYUC. Dr. Gomersall is a member of an educational subgroup of the
   International Forum of Acute Care Trialists. Dr. Hodgson is a member of
   the Australian National Health and Medical Research Council guidelines
   (COVID-19) and leading funded trials in early rehabilitation and ECMO.
   Dr. Moller contributed to guideline work for DASAIM, SSAI, GUIDE, and
   ESA. Dr. Iwashyna is a member of the ATS, the NIH, and an informal
   (unincorporated) organization called the Critical and Acute Illness
   Recovery Organization. Dr. Jacob co-directs the African Research
   Collaboration on Sepsis (ARCS, funded by UK National Institute for
   Health Research, sponsored by Liverpool School of Tropical Medicine), he
   is Secretary General for the African Sepsis Alliance, and is a technical
   expert for the World Health Organization panels. Dr. Kleinpell is a
   board member of the World Federation of Intensive and Critical Care,
   American Nurses Credentialing Center, and the Tennessee Nurses
   Association Political Action Committee. Dr.; Klompas received funding
   from Up-to-Date; he is a member of the guidelines committees of the
   Infectious Disease Society of America (IDSA) and Society of Healthcare
   Epidemiologists of America (SHEA). Dr. Koh is a member of The Korean
   Society of Critical Care Medicine, The Korean Academy of Tuberculosis
   and Respiratory Diseases, The Korean Society of Medical Ethics, and the
   Asia Ventilation Forum. Dr. Kumar served as an expert witness regarding
   a lethal dose of narcotics. Dr. Kwizera is president of the Intensive
   Care Society of Uganda and PRO for the Association of Anesthesiologists
   of Uganda. Dr. Lobo received funding from Pfizer, MSD, Edwards, and
   Nestle; she is the principal investigator in new antibiotics research
   led by CROs/industry; she is a member of the AMIB Executive Board and
   was elected president for 2020-2021. Dr. McGloughlin is a member of
   ANZICS (Australian New Zealand Intensive Care Society). Dr. Mehta
   participated in two non-interventional studies by ISCCM-Hermes and
   Indicaps. Dr. Mer has been an invited speaker for educational talks in
   industry-sponsored symposia for which honoraria was received; he is the
   current Vice President of the Southern African Society of Thrombosis and
   Haemostasis (SASTH), and is involved in annual congress organization; he
   is an invited author of the Global guidelines for the diagnosis and
   management of mucormycosis: an initiative of the European Confederation
   of Medical Mycology in cooperation with the Mycoses Study Group
   Education and Research Consortium. Dr. Nunnally is the treasurer of
   SOCCA, committee member of ASA, NYSSA, IARS, AUA, and SAAAPM and serves
   on the American College of Critical Care Medicine Board of Regents. Dr.
   Oczkowski is a member of the European Respiratory Society, and
   contributed to the High Flow Nasal Cannula Guidelines, the Non-Invasive
   Ventilation in COPD Guidelines. Dr. Osborn received funding from Viven
   Inc, Inflammatrix, Beckman, and the Foundation for Barnes Jewish
   Hospital; she is on the advisory board for Beckman, Inflammatix, and
   Viven; she is a member of the American College of Emergency Physicians,
   American College of Chest Physicians, American Medical Association,
   Society of Academic Emergency Medicine, and American Academy of
   Emergency Physicians; she served as an expert witness in a case related
   to viral as compared to bacterial sepsis. Dr. Papathanassoglou is a
   member of the World Federation of Critical Care Nurses (Editor of
   Journal) and the Canadian Association of Critical Care Nurses. Dr.
   Perner received a research grant from Pfizer Denmark. Dr. Puskarich is
   the co-inventor of a patent to assess Locarnitine drug responsiveness in
   sepsis (USPO 10330685); he is a member of the Society for Academic
   Emergency Medicine, American College of Emergency Physicians (ACEP); he
   was invited to a recently gathered ACEP early sepsis treatment policy
   task force asked to develop specialty recommendations for early sepsis
   treatment. Dr. Roberts received funding from MSD, The Medicines Company,
   Cardeas Pharma, Biomerieux, QPEX, Cipla, and Pfizer; he consulted for
   MSD, QPEX, Discuva Ltd, Accelerate Diagnostics, Bayer, Biomerieux,
   UptoDate, and Australian Therapeutic Guidelines; he is a member of the
   Society of Hospital Pharmacists of Australia Leadership Committees for
   Critical Care and Infectious Diseases and the Lead of Sepsis Working
   group for the International Society of Anti-infective Chemotherapy. Dr.
   Schweickert is a paid consultant to the American College of Physicians
   (last performed in Spring, 2019). Dr.; Seckel volunteers for AACN and is
   a paid consultant to revise online Critical Care Orientation. Dr.
   Sevransky received funding from the Marcus Foundation-PI VICTAS Trial
   and serves on the American College of Critical Care Medicine Board of
   Regents. Dr. Welte received funding from Astellas, AstraZeneca,
   Boehringer, Basilea, Bayer, Berlin-Chemie, Grifols, Infectopharm,
   Mundipharma, MSD, Novartis, Pfizer, DFG, EU, BMBF, and Insmed; he is on
   the advisory board for AstraZeneca, Boehringer, Bayer, Gilead, GSK,
   Insmed, Novartis, Pfizer, Roche; he is a member of the European
   Respiratory Society, German Society of Pneumology, and Paul Ehrlich
   Gesellschaft. Dr. Zimmerman is a member of the ACP, AACP, and WFPICCS.
   Dr. Levy is a legal consultant for a few cases involving sepsis and
   serves as co-chair of the Surviving Sepsis Campaign Steering Committee.
   The remaining authors have disclosed that they do not have any potential
   conflicts of interest.
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NR 647
TC 123
Z9 126
U1 43
U2 54
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0090-3493
EI 1530-0293
J9 CRIT CARE MED
JI Crit. Care Med.
PD NOV
PY 2021
VL 49
IS 11
BP E1063
EP E1143
DI 10.1097/CCM.0000000000005337
PG 81
WC Critical Care Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA WG1WM
UT WOS:000706788600001
PM 34605781
OA Green Submitted, Green Published, Bronze
DA 2022-07-18
ER

EF